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LGE1

Gene
LGE1
Protein
Transcriptional regulatory protein LGE1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
332 amino acids
Function
Required to activate transcription of PDR3, a gene involved in retrograde regulation of multidrug resistance, a phenomenon that takes place in cells that have lost their mitochondrial genome. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear and is independent of retrograde regulation of multidrug resistance function.
Mass
37.309 kDa
Sequence
MSGYTGNNYSRYSSTPPRQRGGYHHARRSRGGAGGSYYRGGNASYGARYNSDYEQPPQEGDLRQTGAYYRNGYTDTRPYYSANSRHYQAQPSPRYNNGTNSYHLPQRGNSQDTNGRTTSASQEDNDEKRVKSRYRNMQADHPRQQPMSVGSTSSRNGSSGNSSTSSTSNGLPPPPSVSSITNNRSYHSSAYPYSSSHTYNNYHHRETPPPPPSNGYYAKGYPVHVPENRSNSDGSSSSVVKKKRILDMKDSPFIYLTDFDKNVKKTNNTESECEKAREVFKESDSIDSALEELNLKINSNELELRLLNNQCDKHALNIQLTQEKLDSLLLMQ

Gene
LGE1
Protein
Transcriptional regulatory protein LGE1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
313 amino acids
Function
Involved in transcriptional activation. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear (By similarity).
Mass
34.425 kDa
Sequence
MSDERYQSRYGRYDSGRGGRSGYYSNYQNSSHHRSNDGPNTNTHGPSNGNGNSGGYYHGYYNRHGSMNGRAASSGRGYYGGHNTHITSAPHNNPNAYSRAPATGNTSYTGSYYSRGGNSSGRGGYSSYNRGGYHASHQYNNGGYYHRNNNYNSSYTERQKSVSGDSATSGGMKYTSSHRTTHVTHPAHPPITIQRSGSNGNGVAQGNASSGEVPTAPRRETTAQNNGRDKREEQLKKYGISNMAQGYLEIMDQNSSSTTSVTQTEIELDEKLREMNSQVFRTMCELALVENQYTRDTLNVQLTQEKLDTLLLS

Gene
LGE1
Protein
Transcriptional regulatory protein LGE1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
244 amino acids
Function
Involved in transcriptional activation. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear (By similarity).
Mass
26.264 kDa
Sequence
MSFSGEHPGNANNEGPPPPPPPPPPPSHSSAPPSSQGGSARAAPLNGAFHSHQPHSQGYARAEGSNGYRQPYGRGGYRGSGGRYYGGYGYGHGGGGYGYGHGGGGNYGHGHHGYYGYQGEYRGHSGYQRFNSPAPVGTRYSGAAGPAARPPPPPEPEPEQPFELTDDPLFHLTELDRSTDDPRQLDEMRRIFKDSVQLDQKLEQQKLAMWRTELELSLLDTQSAKDALNVQLNQENLDALLMQG

Gene
LGE1
Protein
Transcriptional regulatory protein LGE1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
230 amino acids
Function
Involved in transcriptional activation. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear (By similarity).
Mass
26.07 kDa
Sequence
MSEPNEGGSSYRSGGNYNGYKPSGNRYQPNSNNRGPPRYRSNHRQDGGYYNNGGYHQQQGYGYGQPTHAHGVQRQTYRGGSYHPYQHSDSRYGSNSTYRRPYGQQSVPPAPPPSTASSVSSSSAYSRGSNVLPVSRNSYPSPKYEQPKKKFTIPKDENPFIYMMSNDDHSRTSKLKEVYKENDQIDNKLEELKLKIFKDELELGLMSTQCEKDALNVQLTQEKLDSLLMN