Protein
Leptin receptor gene-related protein
Function
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin/LEP. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability (By similarity).
Similarity
Belongs to the OB-RGRP/VPS55 family.
Sequence
MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFHAISPIPHFIAKRATYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVSVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGDDFSWEQW