Protein
Alpha-onocerin synthase LCD
Organism
Lycopodium clavatum
Function
Oxidosqualene cyclase involved in the biosynthesis of alpha-onocerin, a triterpenoid characterized by a symmetrical structure due to cyclizations at both termini of dioxidosqualene that inhibits acetylcholinesterase. Catalyzes the second half of the cyclization, exclusively from pre-alpha-onocerin.
Similarity
Belongs to the terpene cyclase/mutase family.
Sequence
MWRLRTGSSTVDKADSWLSSLNNHLGRQIWCYDPEAGTPQEREAVEAECARFTANRHQQRQSADTLLRLQFQKEHSANRLPSRITVNEDHEVTEDDVTTTLCRALQFYSQLQTDDGHWSGDHSGPMFFLPGMVIALYVTGALDSVLSEHHQREICRYIYNHQRQDGSWGLHPEGTGTLFGTVLSYVTLRLMGESKSNSNNREALRKAQTWIIDHGGATDVPSWGKFWLAVLGVYEWSGVNPLPPESWLLPKSLIAHPGRLPVLYRFIFLPMSYIYARRLSHHLTKIIEDLRKELYTIPYEDIDWNHARKLGAKEEIVPRSVVQDVILSILHNYVEPIMSHWPGFLLRQKALALIMEHIHHEDETTQYLCVCPVSKALNMLCCWLEDRNSDAFKKHLSRVLDFLWLSEDGMKMQVCNGSQLWDTALSVRALISANLLNECSSMLRRAKLYIENTQIQESYPGDLDHWHRITSKGGWPQSTRDWGWPVSDCTAEALQAVLALSSQSTTDVGEALPEERIHECINVLLSFQKSNGSFAPFDARNPLEGPKIWNHTESPGYKSLDFECVECTSSVIQALAAFNKIYPEHRAKEISISIQEGTRFIERLQNSDGSWSGTWGICFTYATWFGIMGLLASGARYYESIAIQRACEFILSKQLPNGGWGEHFHSFKNKVYTNLEGERAHVVHTSWSMLALLATGQEGRDAIPLHRAAKILINAQMETGDYSQEGVVGAVCGDHTISYATYRCVFPIWALGEYRYKLFGKKNMYI