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Kremen1

Gene
Kremen1
Protein
Kremen protein 1
Organism
Rattus norvegicus
Length
473 amino acids
Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Mass
51.869 kDa
Sequence
MAPPAARLALLSAAALTLAARPAPGPRPSPECFTANGADYRGTQSWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKHGEAASTECNNVCFGDHTQPCGGDGRIILFDTLVGACGGNYSSMAAVVYSPDFPDTYATGRVCYWTIRVPGASRIHFNFTIFDIRDSADMVELLDGYTHRVLVRFDGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAINQTLAEVITEQANLSVSAAHSSKVLYVITSSPSHPPQTVPGSHSWVPSVGASGHRVEGWTVYGLATLLILTVTAVVAKILLHVTFKSHRVTASGDLRDCRQPGTSGEIWTIFYEPSTTISIFKKKLKGQSQQDDRNPLVSD

Gene
KREMEN1
Protein
Kremen protein 1
Organism
Homo sapiens
Length
473 amino acids
Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane. Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification.
Mass
51.744 kDa
Sequence
MAPPAARLALLSAAALTLAARPAPSPGLGPECFTANGADYRGTQNWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKYGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMSSVVYSPDFPDTYATGRVCYWTIRVPGASHIHFSFPLFDIRDSADMVELLDGYTHRVLARFHGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQAVKEELPQERPAVNQTVAEVITEQANLSVSAARSSKVLYVITTSPSHPPQTVPGSNSWAPPMGAGSHRVEGWTVYGLATLLILTVTAIVAKILLHVTFKSHRVPASGDLRDCHQPGTSGEIWSIFYKPSTSISIFKKKLKGQSQQDDRNPLVSD

Gene
Kremen1
Protein
Kremen protein 1
Organism
Mus musculus
Length
473 amino acids
Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6 (PubMed:12050670). In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt-independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1 (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation (PubMed:18505822). Modulates cell fate decisions in the developing cochlea with an inhibitory role in hair cell fate specification (PubMed:27550540).
Mass
51.673 kDa
Sequence
MAPPAARLALLSAAALTLAARPAPGPRSGPECFTANGADYRGTQSWTALQGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYVAEHEDGVYWKYCEIPACQMPGNLGCYKDHGNPPPLTGTSKTSNKLTIQTCISFCRSQRFKFAGMESGYACFCGNNPDYWKHGEAASTECNSVCFGDHTQPCGGDGRIILFDTLVGACGGNYSAMAAVVYSPDFPDTYATGRVCYWTIRVPGASRIHFNFTLFDIRDSADMVELLDGYTHRVLVRLSGRSRPPLSFNVSLDFVILYFFSDRINQAQGFAVLYQATKEEPPQERPAVNQTLAEVITEQANLSVSAAHSSKVLYVITPSPSHPPQTAPGSHSWAPSVGANSHRVEGWTVYGLATLLILTVTAVVAKILLHVTFKSHRVPASGDLRDCRQPGASGDIWTIFYEPSTTISIFKKKLKGQSQQDDRNPLVSD

Gene
kremen1
Protein
Kremen protein 1
Organism
Xenopus laevis
Length
452 amino acids
Function
Receptor for Dickkopf proteins. Cooperates with DKK1/2 proteins to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (PubMed:17978005, PubMed:18314504).
Mass
50.189 kDa
Sequence
MVMDIWTISLRILLFPSALVLCSDSFHSECYTVNGADYRGTQNQTSLDGGKPCLFWNETFQHPYNTLKYPNGEGGLGEHNYCRNPDGDVSPWCYIPEQEDGVYWKYCDIPACKMPGNLGCFRDHGNPPPLTGISETSNKQTIQTCITMCRRQRYKLAGLEAGFACFCGNNADYRKHGEMPSTDCNSVCFGDHTQPCGGDGRIILFDSLIGACGGNYSTDSAVIYSPDFPDTYGTGKACYWTIQVTDASIIRFNFTLFDIKDSRDMVELLDGYTKQVLIRFDGRNHPTHSFNISLDFVILYFFSDRINQAQGFSVVYEAFKEETIEKPNGSNNPSQTEMITQTTNLSINAARSSKILYVITTSPSRPSGHVPGWTIYALTGLLILTIIAISAKALLHISMKSARLASSSSLDSCHRGSAGEIWSIFYKPSTSISIFPKKLKGQHDDRNPLVGE