About Products Protein Database Contact

Ken-146

Gene
Ken-146
Protein
Probable AP endonuclease
Organism
African swine fever virus (isolate Pig/Kenya/KEN-50/1950)
Length
296 amino acids
Function
Endonuclease that plays a role in DNA repair. Cleaves phosphodiester bonds on the 5' side of apurinic or apyrimidinic sites (AP sites). In addition to endonuclease activity, the ASFV enzyme has a proofreading 3'-5' exonuclease activity that is considerably more efficient in the elimination of a mismatch than in that of a correctly paired base. Displays 3'-phosphatase and 3'-repair diesterase activities. The single nucleotide gaps generated by the AP endonuclease are filled by the viral AP endonuclease and DNA ligase (By similarity).
Similarity
Belongs to the AP endonuclease 2 family.
Mass
33.46 kDa
Sequence
MFGAFVSHRLWSDSGCTTTCIANSIANYVAFGEQIEFPFKSAQVFIAGPRKAVINIQEEDKAELSKMIAKHNLWVVAHGTYLDVPWSSRSAFVTHFIHQELLICKEVGIKGLVLHLGAVEPELIVEGLKKIKPVEEVVIYLETPHNKHHAYKYSTIEQIKELFLRIRNSRLKHIGLCIDTAHIWSSGVNISGYNDAGQWLRSLENIHSVIPPSHIMFHLNDAATECGSGIDRHASLFEGMIWKSYSHKIKHSGLYCFVEYITRHQCPAILERNLGSSMQLQTALTTEFHTLKSLLK