kank2

KN motif and ankyrin repeat domain-containing protein 2

1085 amino acids

May be involved in different biological processes including transcription and apoptosis by sequestering specific proteins outside of the nucleus (By similarity). Involved in actin stress fibers formation probably through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457).

116.153 kDa

MTIMAQVLHMDSSFPGKINPPVPPSLHAKDQEAPYSVETPYGYRLDLDFLKYVNDIEKGNTIKKVPVQRRPRYGSLPRGYGYTGSWWTSTESLCSNASMDSRHSSYSYCAPGFHTSQRPNFSTARVEKTLMDARRKLEEEKDGRRFSNLGSMHSSMAGSNTSLSSAHSFNRAQGGGSYTPMSSGLSTPVSPTPAHLQHVREQMAVALRKIRELEEQVKTIPVLQVKISVLQEEKRQLSVQLKSQKFLGHTLGFNRSRPRGELYIDIPEEEAGNGAGAANKATGSLSPTTPGSLQDSGCEIEETVIVAGARPGAKREVRTVGVGPEAEERGYRQVGVGVREQDLGLLPETEALKTKVGLLEVQLRKTMQELQSAQQQVEAAQKERQTVCPQVDHAVRATSLGWQDQQGQAGAGLHTVVSFTKQPHQQRTVGIQVYTLEQPTVVGVGTLLRAQGCTHPAQLEASHRRYGESPAAGDSPHEFPIAISSKQVREVLRSEVSKSVPVTNQATPMETKCNQVTAVCQRLKEGEINQQPAEEAIQVDPANPASPQSNLRSIMKRKADGEPGSPYTKKNLQFLGVNGGYESTSSEESSSESSEDESDASEYHEATEKLPESATPQSLVSSCIPQLASETPATQTAQHSTAQIPTNHTPAAQTTSQSHTTDATTQQHVTQSPAAEADVQHCVSQSSVTTTPPPEGDVQCVFQGCNPPSTATSLEQNSVQLSSATQQSKATDSNVQPDLAQTDVSDFAAQQTTTQTQFTSAKPQQEASQSKTADLTAQKGATHSTDGSAKQDIAISSTTKPAADTATPPTNKQTDSLELSGGLMSALHILQKALSEPNAFSHQDARTAYTSVLQEWLRVSCHKAADTAVVKAHMDAFASISPQLLEFVINMADGNGNTALHYTVSHSNFPVVKLLLDTGLCNADKQNKAGYTAIMLTALAAFSSDSDLQTVLQLLRTGDVNAKASQAGQTALMLAVSHGRGDMVKALLACGAQVNLRDDDGSTALMCACEHGHVDIVRQLLSVPGCDATLTDNDGSTALSIALEASQNDIAVLLYAHLNFAKPPSPVSPKSPILGSSPPSSSELK

KANK2

KN motif and ankyrin repeat domain-containing protein 2

858 amino acids

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity).

91.957 kDa

MAQVLHVSAPFPGTPGPASPPAFPSKEPDVPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLGSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAAAPAGLGSLTPSAAGSTSSLVGVGLPPPTPRGSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPAGARGRGELCLDLPEAPEDPVTLETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKALQELQAAQARQADLPPQAWPPPDSPVRVDTVRVVQGPREVEVAASTAAGAPAQRAQSLEPYGAGLRALATSNGAESPPVFRSHEVMETVFPAPTASTSNVHQVKKISITERSCDGAAGHPQAPAESSLSPPESEGATQAQPEKNTGQVPAHDDTTIKEPIRQAACHESEFEEAGGAGGAQAGLRSIMKQKEEPTDPEAHRRSLQFVGVNGSISPRYESSSEDSSTAENFSDNESTENEAPEPEERVPSVAEAPQLRPKETAKAKTSREESQLPQESLHTPTAEGASGSSAKDEIRMELSPDLISACLALEKYLENPKALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCQVDKQNRAGYSPIMLTALATLKTQDDIQTILQLFRLGDVNAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEITALLLAVPSCDISITDRDGSTALMVALDAGHSEIASMLYSRMNIKCSFAPMSDDESPASSSAEE

KANK2

KN motif and ankyrin repeat domain-containing protein 2

851 amino acids

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (PubMed:17476305). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (PubMed:22371500). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (PubMed:22371500). Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:17996375, PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (By similarity).

91.174 kDa

MAQVLHVPAPFPGTPGPASPPAFPAKDPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLSSLPRGPGSWWTSTESLCSNASGDSRHSAYSYCGRGFYPQYGALETRGGFNPRVERTLLDARRRLEDQAATPTGLGSLTPSAAGSTASLVGVGLPPPTPRSSGLSTPVPPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPTAGRGRSELCLDLPDPPEDPVALETRSVGTWVRERDLGMPDGEAALAAKVAVLETQLKKALQELQAAQARQADPQPQAWPPPDSPVRVDTVRVVEGPREVEVVASTAAGAPAQRAQSLEPYGTGLRALAMPGRPESPPVFRSQEVVETMCPVPAAATSNVHMVKKISITERSCDGAAGLPEVPAESSSSPPGSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENISDNDSTENEAPEPRERVPSVAEAPQLRPAGTAAAKTSRQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVQQLLDSGVCKVDKQNRAGYSPIMLTALATLKTQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDDESPTSSSAEE

Kank2

KN motif and ankyrin repeat domain-containing protein 2

847 amino acids

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (By similarity). Through the Rho signaling pathway may also regulate cell proliferation (By similarity).

90.884 kDa

MAQVLHVPAPFPGTPGQASSAAFPNKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVPVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRSGTNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAVLETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGAPAQRAQSLEPYGAGLKALATSAENTLVFRSHEVVETMCPLPTASTSNMHTAKKISITERNCTGAARMADPPPSPAEPSPSSPYPAAEPENPAPAAQDTTDRELTRPVASQDSQAAEGAGGASLGVQSALKRKEVPADPDVHQRNLQFVGINGGYESSSEDSSTAENSEHESTENEAPEPPVRVLSTAEGPQLRPLGPAVGKTSQDERQLSQESQRVPEAKVAPGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCQVDKLNRAGYSPIMLTALATLKTQDDIDTILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVKALLACEVDVNMQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE

Kank2

KN motif and ankyrin repeat domain-containing protein 2

843 amino acids

Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (PubMed:25961457). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney (PubMed:25961457). Through the Rho signaling pathway may also regulate cell proliferation (PubMed:16024821).

90.245 kDa

MAQVLHVPAPFPGTPGQASPAAFPSKEPDPPYSVETPYGYRLDLDFLKYVDDIEKGHTLRRVAVQRRPRLGSLPRGPGSWWTSTESLCSDASGDSRHSAYSYCGRGFYPQYGALETRIGSNPRVERTLLDARRRLEDQAAAPSSGGLGSLTPSAAGSTSSLAGVGLLPPTPRSSGLSTPVAPSAGHLAHVREQMAGALRKLRQLEEQVKLIPVLQVKLSVLQEEKRQLTVQLKSQKFLGHPSGTRSRSELCLDLPEAPDDPAALETRSVGTWVRERDLGIPDGEAALVAKVAVLETQLKKALQELRAAQTQQVDLQPQAWPPPDTQVRVDTVRVVEGPREVEVAASTAAGALAQRAQSLEPYGTGLKALTTSGGPENTLVFRSHEVVETMCPLPTATTGNVHTAKKISITERSCTGAPRMTEPSSVNPRPAAASVVQPENPVPAAQDTTDKKPTRPAAASQDSQAADGAGRASLATKRKEDPADPEVNQRNLQFVGVNGGYESPSEDSSTAENSEHESTENEGPEPPARVLSPAECPQLRPPGAAVATTSLEGPQLSQESQRVPAPEVASGPDPEEEIRMDLSPDLISACLALEKYLENPNALTERELKVAYTTVLQEWLRLACRSDAHPELVRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGYSPIMLTALATLKTQDDIETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNIQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSAEE