Protein
Inosine/xanthosine triphosphatase
Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Function
Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Similarity
Belongs to the YjjX NTPase family.
Sequence
MHHVVSATTNPAKIQAILQAFDEIFGEGSCHIESVAVESGVPEQPFGSEETRAGARNRVANARLARPNADFWVAIEAGIDDDSTFSWVVIESASQRGEARSATLPLPDVILEQVRAGEALGPVMSQYTGIDQIGRKEGAIGVFTGGRLTRSSVYHQAVVLALSPFHNAIYR