Protein
Lipoyl synthase, mitochondrial
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Sequence
MLKPGIRSVQKRFITETVVRSTQPSVSRRRKTTHFTDKLNKGPSFEDFVNGNAQKFTLDPLEKARQNSEEVQRLPTWLKVPIAKGSNFHKLKNDVKELKLSTVCEEAKCPNIGECWGGGDKSKATATIMLLGDTCTRGCRFCSVKTNRKPSAPDPTEPENTAEAISRWGLGYVVLTTVDRDDLVDGGAYHLAETVQKIKQKAPNILVETLSGDFRGDLEMVKVMALSGLDVYAHNMETVEALTPHVRDRRATYRQSLSVLECAKKTVPTLVTKTSVMLGLGETDEQVLQTMKDLRAIGCDVITFGQYMRPTKRHMKVVEYVTPEKFDYWKQKALELGFLYCASGPLVRSSYKAGESFIENVLRGRSRARI