Protein
Very-long-chain 3-oxoacyl-CoA reductase
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Function
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Sequence
MVALIDQLYNVTALRECSSLNVAAWIVFGLGISKMVFLTLNFSKMVLDLFVLPGPDFKKYGKGKGAYAVVTGASDGIGKEYAKQLAKRGFNLILISRTESKLVELKKEIETECKIDVKILAIDVSSDSKENYTLIREVASGLPVTVLINNVGKSHSIPVPFDQTEESELRDIITINNTATLMITQTLLPQLKASVKTLKCRGLILTMGSFGGLLPTPFLATYSGSKAFLQSWSNALAGELSSDSIDVELVLSYLVTSAMSKIRRSSALIPSPKAFVRSTLNSIGKRCGAQERFATSTPYWSHALYHFIIENTVGVYSKIANSINYSFHLSIRKRALKKAERQAKKQ