KLK1

Blarinasin-1

280 amino acids

A kallikrein-like protease. It preferentially converts human high-molecular-weight kininogen (HK) to bradykinin. Displays broad substrate specificity in vitro, with highest activity toward Boc-Val-Leu-Lys-MCA, Boc-Glu-Lys-Lys-MCA, Boc-Glu(OBzl)-Ala-Arg-MCA, Boc-Val-Pro-Arg-MCA, ZPhe-Arg-MCA and Pro-Phe-Arg-MCA. Has preference for Arg and Lys in position P1 and hydrophobic residues in position P2. Is not toxic to mice.

Belongs to the peptidase S1 family. Kallikrein subfamily.

30.963 kDa

single

YLLLLCLPLTLMGTGAVPPGPSIEIHPRIVGGWECDKHSQPWQALLTFTNGLDGVCGGVLVHPQWVLTAAHCIGDNYKIKLGLHDRFSKDDPFQEFQVSASFPHPSYNMRLLKLLLSDELNDTYYDEISLGADFSHDLMMMQLEKPVQLNDAVQVLDLPTQEPQVGSKCHASGWGSMDPYSRNFPRTGKLQCVDLTLMSNNECSRSHIFKITDDMLCAGHIKGRKDTCGGDSGGPLICDGVFQGTTSWGSYPCGKPRTPGVYVKIFSHVDWIREIIATHS

KLK1

Blarinasin-1

280 amino acids

A kallikrein-like protease. It preferentially converts human high-molecular-weight kininogen (HK) to bradykinin. Displays broad substrate specificity in vitro, with highest activity toward Boc-Val-Leu-Lys-MCA, Boc-Glu-Lys-Lys-MCA, Boc-Glu(OBzl)-Ala-Arg-MCA, Boc-Val-Pro-Arg-MCA, ZPhe-Arg-MCA and Pro-Phe-Arg-MCA. Has preference for Arg and Lys in position P1 and hydrophobic residues in position P2. Is not toxic to mice.

Belongs to the peptidase S1 family. Kallikrein subfamily.

30.963 kDa

single

YLLLLCLPLTLMGTGAVPPGPSIEIHPRIVGGWECDKHSQPWQALLTFTNGLDGVCGGVLVHPQWVLTAAHCIGDNYKIKLGLHDRFSKDDPFQEFQVSASFPHPSYNMRLLKLLLSDELNDTYYDEISLGADFSHDLMMMQLEKPVQLNDAVQVLDLPTQEPQVGSKCHASGWGSMDPYSRNFPRTGKLQCVDLTLMSNNECSRSHIFKITDDMLCAGHIKGRKDTCGGDSGGPLICDGVFQGTTSWGSYPCGKPRTPGVYVKIFSHVDWIREIIATHS

KLK1

Kallikrein-1

262 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.89 kDa

MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS

KLK1

Kallikrein-1

262 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.89 kDa

MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS

Klk1

Kallikrein-1

261 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.775 kDa

MRFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWQVAVYRFTKYQCGGILLNANWVLTAAHCHNDKYQVWLGKNNFLEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVKYEYPDELQCVNLKLLPNEDCAKAHIEKVTDDMLCAGDMDGGKDTCAGDSGGPLICDGVLQGITSWGPSPCGKPNVPGIYTRVLNFNTWIRETMAEND

Klk1

Kallikrein-1

261 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.775 kDa

MRFLILFLALSLGGIDAAPPVQSRIVGGFNCEKNSQPWQVAVYRFTKYQCGGILLNANWVLTAAHCHNDKYQVWLGKNNFLEDEPSAQHRLVSKAIPHPDFNMSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSITPVKYEYPDELQCVNLKLLPNEDCAKAHIEKVTDDMLCAGDMDGGKDTCAGDSGGPLICDGVLQGITSWGPSPCGKPNVPGIYTRVLNFNTWIRETMAEND

KLK1

Kallikrein-1

258 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.339 kDa

MWFLVLCLALSLGGTGAAPPIQSRIVGGWECSQPWQAALYHFSTFQCGGILVHPQWVLTAAHCIGDNYQLWLGRHNLFDDEDTAQFVHVSESFPHPCFNMSLLKNHTRQADEDYSHDLMLLRLTQPAEITDAVQVVELPTQEPEVGSTCLASGWGSIEPENFSYPDDLQCVDLKILPNDKCAKAHTQKVTEFMLCAGHLEGGKDTCVGDSGGPLTCDGVLQGVTSWGYIPCGSPNKPAVFVRVLSYVKWIEDTIAENS

KLK1

Kallikrein-1

258 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.339 kDa

MWFLVLCLALSLGGTGAAPPIQSRIVGGWECSQPWQAALYHFSTFQCGGILVHPQWVLTAAHCIGDNYQLWLGRHNLFDDEDTAQFVHVSESFPHPCFNMSLLKNHTRQADEDYSHDLMLLRLTQPAEITDAVQVVELPTQEPEVGSTCLASGWGSIEPENFSYPDDLQCVDLKILPNDKCAKAHTQKVTEFMLCAGHLEGGKDTCVGDSGGPLTCDGVLQGVTSWGYIPCGSPNKPAVFVRVLSYVKWIEDTIAENS

KLK1

Kallikrein-1

257 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.237 kDa

MWFLVLCLALSLGGTGRAPPIQSRIVGGWECSQPWQAALYHFSTFQCGGILVHPQWVLTAAHCISDNYQLWLGRHNLFDDEDTAQFVHVSESFPHPGFNMSLLKNHTRQADDYSHDLMLLRLTQPAEITDAVQVVELPTQEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLEILPNDECAKAHTQKVTEFMLCAGHLEGGKDTCVGDSGGPLTCDGVLQGVTSWGYIPCGSPNKPAVFVKVLSYVKWIEDTIAENS

KLK1

Kallikrein-1

257 amino acids

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Belongs to the peptidase S1 family. Kallikrein subfamily.

28.237 kDa

MWFLVLCLALSLGGTGRAPPIQSRIVGGWECSQPWQAALYHFSTFQCGGILVHPQWVLTAAHCISDNYQLWLGRHNLFDDEDTAQFVHVSESFPHPGFNMSLLKNHTRQADDYSHDLMLLRLTQPAEITDAVQVVELPTQEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLEILPNDECAKAHTQKVTEFMLCAGHLEGGKDTCVGDSGGPLTCDGVLQGVTSWGYIPCGSPNKPAVFVKVLSYVKWIEDTIAENS