klhl21

Kelch-like protein 21

615 amino acids

Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).

70.129 kDa

MESPINTSPDSVGIPAPEAALPFYDASHALHLLRGINELRSEQKFFDMTVSAGGQDFPCHRTVLAAASNYFRAMFAGRLRESHADRVELHDVSGPILSLLLDFCYTGRVTVTLENVEPLLQAADLFQFPSVKQACCAYLEQQLDVSNCLEIQDFAEAYACQGLAESTKRFILGHIAQLAQAHEVERLTFKRMLEYISDDRLCVDKEESAFQIALQWVKADPKHRQYRWPELFQYLRLPFIRRFYLLAYVESDPLVFRSPYCLQLIREARAFQSSEYDRHDWLCHRMKPRPSTGLAEILVVVGGCDQECDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIAALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVSPMLKAREYHSSTVLNGLLYVIASDSTERYDPTMDTWESLHPMLYPMDNCSTTSCRKKLYAIGSLEGQESMVMQCYNPDTNVWAMVNCGQLPPWSFAPKTVTLNGLIYFVRDDSPEVDVYNPSKNEWDKIPPMIQVHVGGSLAALGGKLYVSGGYDNTFELSDVVEAFDPETRSWSLMGRLPQPTFWQGSVSIFRQFMPQTQQSLDGVPSDNTNNERNIINLNRRRHHLHNHNFNELHRR

klhl21

Kelch-like protein 21

613 amino acids

Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB (By similarity).

69.737 kDa

MEKPVLQTQPSMLPFFDTAHAVNLLRGIHELRAERKFFDVTLCAEGKEFHCHRTVLAAASMYFRAMFAGTLRESVMDRVVLHEVSAELLGLLVDFCYTGRVTVTHDNVDLLLKTADLFQFPSVKEACCAFLEQRLDVSNCLEIQDFAEAYACRELAASARRFVLKNIVELAKSMDFERLSWKRLLEFVSDDGLCVDKEETAYQIAVRWVKADLQHRLHYWPELLQQVRLPFVRRFYLLAHVESDPLVYLSPACLRLVSEARSFQSYEYDRHDRPGHRMRPRPSTGLAEILVVVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIAALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVSPMLKAREYHSSCVLKGQLYVVGSDSTERYDHTIDCWEALPPMPHPMDNCSTTACRGRLYAIGSLTGEDTMAIQCYDAESNRWSLLNSGELPPWSFAPKSVTLNGLIYFVRDDSAEVDVYNPQKNEWDKISPMTQVHVGGSVSALGGRLYVSGGYDNTFELSDVVEVYDPSSRSWSPAGRLPQPTFWHGSVSIFRQFMPLVQSTFEPIDIPEANAIHLHRHHRNQALHNHNNNVNQNHNQEVNQVH

KLHL21

Kelch-like protein 21

597 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).

66.563 kDa

MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLTNCLDMQDFAEAFSCAGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLESVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYHPDMDLWSLVDCGQLPPWSFAPKTVTLNGLMYFIRDDSAEVDVYNPTKNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPLGGRGFELDGGSSDMDVGQPRPPQNPAELH

KLHL21

Kelch-like protein 21

597 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome.

66.617 kDa

MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTFSGGRGFELDSGSDDMDPGRPRPPRDPDELH

Klhl21

Kelch-like protein 21

597 amino acids

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).

66.547 kDa

MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAPHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLDGLLYVVAADSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVIQCYDPDTDLWSLVNCGQLPPWSFAPKTVTLNGLMYFVRDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPAGGRGFELNSGSNDVDAGYHRLPQNPEELH

Klhl21

Kelch-like protein 21

597 amino acids

Substrate-specific adapter of BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity).

66.448 kDa

MERPAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGELGAEQLERLPLARLLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWTEVAPMLKAREYHSSSVLNGLLYVVAADSTERYDHATDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVIQCYDPDTDLWSMVNCGQLPPWSFAPKTVTLNGLMYFVRDDSAEVDVYNPTKDEWDKIPSMNQVHVGGSLAALGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFMPQTPAGGRGFELNSGSSDVDAGHHRLPQNPEELQ