KCP

Gene

kcp

Protein

Kielin/chordin-like protein

Organism

Xenopus laevis

Length

2327 amino acids

Function

May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm.

Mass

255.802 kDa

Sequence

MNTLLWTILLPLLFSFCVCQQPEHQDLEMSVQYYDDNVIDLLEALNVTRSVKGVTKAKGSDPASPAWKFRQRVPHLTLPRDYSVYLLSTTQESLGLHFVAKQAKNNRGTLVAFLSPAATKIDGRPLLRLISDTHTDQLYFEYRTAQTMEPASLHFPGSSPFSGSQWARVALNVNTHKVTLFLDCEEPVVFGKEGAEEMLSLILPLDLEITFASTPSDKESKFLGYWQTAEISPTGFTRRPWHCENRSDSLPLPYSLSGERQMEDEEIQREPRAPDLSDTDHYQQQQSEVPAQLLAKDDRLQRLEEAVKGLTNMIDMIKSQNADLQARVIALESCECRRSTCVWEDKEYQDSETWKKDACNICVCVGGSVTCSVRKDWPQCLGCFHEGRNYNNKDIFSVGPCMSCICQSGEVSCTPKLCPPVTCSDPVTLPNECCPLCATGCSDGHKEGDTWRKDTCTTCTCQNGTISCEREQCPELTCLKRHTPPGQCCAKCQQGCEYEGLIYRNGDYFLSQSNPCVNCSCLNNLVRCLPVQCPLPACTNPVPIPGQCCPSCPVCELDGHPLIPGQNVTTKDGCRLCSCQDGKVQCTESVQCPHICTHGVRSNSCCLDCSACEMHGDIIPNGLTFQGNMDPCESCTCQDGNVHCVRVSCPELSCVLHEKIPGECCSQCQSCMDGTVKRKHGEEWKPQGDPCQSCRCLEGRVQCRKRHCAALCRNPLPPRPGTCCPMCDGCLYNGRSYLNGQPVRSTDQCNRCFCENGNVQCEPIACPQAPCRNPVRRTGECCPRCEGCEYDSRHFAEGVVFTTAHDPCLQCTCLSGEVSCEHLDRKCPPSQCSHPGKAAGQCCPSCDVCDFEGILYTDRQTFQPPGHGPCLKCFCTIGNVRCVEETCPPAPCPNPVRDPEQCCPVCKVCVQDGVEFLEGIEWELDGNPCSSCTCRNGDTVCGVSECPPVSCLHPTRREGECCPVCDSCSYNQRLYSNEQIFTDPDNPCQDCQCKDGTVQCSSIVCPPVLCTIPERTPGQCCAKCPDCRYQDQIFLEGEQFSNPLNQCQECWCRDGHVTCTDRGCTGALCSYPLPGTCCQNNCNGCNYAGKEYPNGADFPHPTDKCRQCHCINGNVQCLAQRCPPLLCAEPFPVPGECCPQCPVPPADCPYSGVTYRHMQRFYDPSDKCRDCICNNGTVTCQRKPCAPTPCLHPLQGDCCRSCDGCLMSGKELANGEQFPQPSDPCSVCVCWEGSVTCQPKTCPVLNCPFPAPGQCCKECQDCQYFGEVYLNGQEFSAPEDSCSRCVCADGFVTCSKKPCYKAGCTHPSTPPGKCCPVCDGCSYNGDALINSQSVPDPSNPLCSECTCRAGSVQCVRKLCGPTSCPHPVTGPCDCPICQGCHFQGHNYIDGEVFTSAQSQCEQCRCMRGHVTCGPRPCDQVTCPHPAEDPCMCPVCDGCNYSGRDCTNGESFPDPEDECSHCTCRNGEVACISVPCPRVSCMYPITPRGECCPRCTGICKHNGRVYQSGDTFHPPGDLCTKCSCQNEMVNCQRVRCSQECSHPVLSPASSCCPVCDRCFYENREYANHETFTSTSDPCQRCVCLDGSVTCTHVVCPYVSCANPITKPGQCCRECPVCRYQGKEFSEGAHWVPHTDPCLKCTCSNGHVDCEPPQCPPLPCTQQVTDPGTCCPRCRGCVYNGREYRDNSNWLSSSDHCMSCMCVDGVTTCSKLQCITSCTNQITIPGECCPVCADCISNSKVYLPGDSYNPSKDPCEICTCESLPNGQQYRHCTKKQCPSLLDCPRSYILPPAEGQCCSSCAQALSNCTNTLVGNEIQATDDPCYTCHCKDLTWVCVHQPCPALSCPRSEQFTHSGSCCPVCNECVVEIEGRRVPDGETWTDRQDPCVTCTCTLGHVECQIEECQPVQCQEGERKVKRPGTCCHECQASAVSCWYQGQRFLSNEHWQVDECTACTCVSGEVHCHSERCPQVSCTAEETPALIPGMCCPHCIPRPATCIAFGDPHYRTFDGKMYHFQGSCTYVLSEDCEGGDFSIHVTNDDRGLRGVSWTKEVTVLIGDAVVQLLQDWVVMVDYQTVELPFLKEPYIYIERKTNTILLNSNIGVKVQWNGRSHLEVSVPGTYRDHLCGLCGNFNNYPQDDLRDRRGQILMSEAAFGNSWRVQSSNDSSSSCWDGQDVDPCKQAGYRARKEANGRCKLLKSSVFEPCHRVVPPEMFFASCVYDLCACGAGDECLCDVLEAYASECREAGVILQWRSPALCAVGCPHDRGYVFDECGPPCPKTCFNKDVPLGVLESHCFKPCVPGCQCPAGLVEHESHCIPPESCPKIIHGNL

Gene

kcp

Protein

Kielin/chordin-like protein

Organism

Xenopus laevis

Length

2327 amino acids

Function

May be a signaling molecule that mediates inductive activities of the embryonic midline. Able to dorsalize mesoderm.

Mass

255.802 kDa

Sequence

Gene

KCP

Protein

Kielin/chordin-like protein

Organism

Homo sapiens

Length

1568 amino acids

Function

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Mass

166.935 kDa

Sequence

MAGVGAAALSLLLHLGALALAAGAEGGAVPREPPGQQTTAHSSVLAGNSQEQWHPLREWLGRLEAAVMELREQNKDLQTRVRQLESCECHPASPQCWGLGRAWPEGARWEPDACTACVCQDGAAHCGPQAHLPHCRGCSQNGQTYGNGETFSPDACTTCRCLTGAVQCQGPSCSELNCLESCTPPGECCPICRPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSPCPEPVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGKIPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQLCPACELDGEEFAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPLPGTCCPNDCSGCAFGGKEYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPRQGPCCPSCDGCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCEPKACAPALCPFPARGDCCPDCDGCEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGRRPCEPPGCSHPLIPSGHCCPTCQGCRYHGVTTASGETLPDPLDPTCSLCTCQEGSMRCQKKPCPPALCPHPSPGPCFCPVCHSCLSQGREHQDGEEFEGPAGSCEWCRCQAGQVSCVRLQCPPLPCKLQVTERGSCCPRCRGCLAHGEEHPEGSRWVPPDSACSSCVCHEGVVTCARIQCISSCAQPRQGPHDCCPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRCHRRQCPSLVGCPPSQLLPPGPQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQACPELSCPLSERHTPPGSCCPVCRAPTQSCVHQGREVASGERWTVDTCTSCSCMAGTVRCQSQRCSPLSCGPDKAPALSPGSCCPRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHSGDFSVHVTNDDRGRSGVAWTQEVAVLLGDMAVRLLQDGAVTVDGHPVALPFLQEPLLYVELRGHTVILHAQPGLQVLWDGQSQVEVSVPGSYQGRTCGLCGNFNGFAQDDLQGPEGLLLPSEAAFGNSWQVSEGLWPGRPCSAGREVDPCRAAGYRARREANARCGVLKSSPFSRCHAVVPPEPFFAACVYDLCACGPGSSADACLCDALEAYASHCRQAGVTPTWRGPTLCVVGCPLERGFVFDECGPPCPRTCFNQHIPLGELAAHCVRPCVPGCQCPAGLVEHEAHCIPPEACPQVLLTGDQPLGARPSPSREPQETP

Protein

Kielin/chordin-like protein: KCP

Gene

KCP

Protein

Kielin/chordin-like protein

Organism

Homo sapiens

Length

1568 amino acids

Function

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways (By similarity).

Mass

166.935 kDa

Sequence

Protein

Kielin/chordin-like protein: KCP

Gene

Kcp

Protein

Kielin/chordin-like protein

Organism

Mus musculus

Length

1550 amino acids

Function

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.

Mass

166.628 kDa

Sequence

MAGARAALLPLLLHLGSLALAARGGEVSREQPRLADAISQQQAPSHSLVPGETHQQQWCPLEERLERLEAEVTDLRKQNRELQARVVQLESCECWGPGHTCPEGARWEPDACTACVCRDGTAHCGPQPNLPHCRGCSHNGQSYGHGETFSPDACTTCRCLAGTVQCQGPSCSELNCLESFIPPGECCPICRPGCEYEGQLHQEGSSFLSSSNPCLQCSCLRSLVRCVPVKCQPSPCLNPVPRLGHCCPVCQASGCTEGNSHRDHGQEWTTPGDPCRICQCLEGHIQCRQRECASLCPYPARPLPGTCCPVCDGCFLNGREHSSGEPVGSQDPCSSCRCTNGSVQCEPLPCPPAPCRYPGRIPGQCCPVCDGCKYQGHEYRSQETFTLQENGRCLRCVCQAGEVSCEEQDCPVTPCVRSASGPQLCSACVLNGEEFAEGIQWEPDDQPCTSCSCQDGVPVCRAVLCSPVPCQHPTQPPGACCPSCDSCTYHSLVYANGQNFTDVDSPCQTCYCEDGTVRCSLINCPFTTCAKPQNGPGQCCPKCPDCILEAQVFVDGERFPHPRDPCQECWCQEGQAHCQLRACPSAPCVHPLPGTCCKNDCTGCAFGGKEYPNGADFPHPTDPCRLCRCLSGNVQCLARRCPPLSCPQPVLTPGDCCPQCPDAPADCPQSGNMVPVRHQEHFFQPGDPCSRCLCLDGSVSCQRLTCPPAPCAHPRRDACCPSCDGCLYQGKEFASGERFPSPNVACHVCLCWEGSVKCEPRTCAPAQCPFPTREDCCPACDSCDYLGVSYLSSQEFPDPREACNLCTCLGGFVTCTRRPCEPPACSHPLIVPEHCCPTCQGCLYHGITAALGETLPDPLDPTCSLCTCEEGSMRCQKKPCPPAPCAHPSPGPCFCPVCRSCLSQGREHQDGEEFEGPEGSCERCRCLAGQVSCTRLQCPSLPCLHQVTEPGTCCPRCTGCLARGEEHPEGSSWVPADSPCSSCMCHKGIITCAQVQCVSACIWPQEGPSDCCPQCSGCEHGGRKYEPGESFQPGADPCEVCICKQKREGPPSLHCSRRQCPSLVGCPPSQLLPPGPQHCCPTCAQALSNCTEDLVGSELVPPDPCYTCQCQDLTWLCTHRACPELSCPLWERHTTPGSCCPVCKDPTQSCMHQGRWVASGEQWAVDACTSCSCVAGTVHCQTQRCRKLACSRDEVPALSPGSCCLRCLPRPASCMAFGDPHYRTFDGRLLHFQGSCSYVLAKDCHGEDFSVHVTNDDRGRRGVAWTQEVAVLLGTVAVRLLQGRTVMVDQHTVTLPFLREPLLYIELRGHTVILHAQPGLQVLWDGQSQVEVRVPSSYRGQTCGLCGNFNGFAQDDLQGPDGRLLPTEASFGNSWKVPKGLGPGRPCSAGREVDPCRAAGYRARREANARCGILKTSPFSHCHAVVPPEPFFAACVYDLCACGPGSSSDTCLCDALEAYASHCRQAGVTPVWRGPTLCVVGCPVDRGFVFDECGPPCPRTCFNRHIPLGELAAHCVRPCVPGCQCPAGLVEHEGHCISPEVCPPVLLTGD

Protein

Kielin/chordin-like protein: Kcp

Gene

Kcp

Protein

Kielin/chordin-like protein

Organism

Mus musculus

Length

1550 amino acids

Function

Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.

Mass

166.628 kDa

Sequence

Protein

Kielin/chordin-like protein: Kcp