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KCNMB3

Gene
KCNMB3
Protein
Calcium-activated potassium channel subunit beta-3
Organism
Homo sapiens
Length
279 amino acids
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Similarity
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
Mass
31.604 kDa
Sequence
MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS

Gene
Kcnmb3
Protein
Calcium-activated potassium channel subunit beta-3
Organism
Rattus norvegicus
Length
239 amino acids
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. May partially inactivate the current of KCNBMA. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer (By similarity).
Similarity
Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB3 subfamily.
Mass
26.447 kDa
Sequence
MQPFSIPVQITLQGGRRRQGRTALPASGISNGDPLKVHPKLPSSAGEDRATLLGIAMMASSVLMFFLLGTTVLKPFMLSSPREESNCTTVHTHIADDWLDFAFTCEGSCQGQGTYPCLQVFVNLSHSGQKVLLHYDEEAIRTNPKCFYTPKCHGDRDHLLNSALDIKEFFDHNNGTFPCFYSPDGPLGVVLRKSGHKVVFHCLFWPLLTLLGGALIVGLVRLTQHLSFQCEKYRAVVRA