KCNIP4

Gene

KCNIP4

Protein

Kv channel-interacting protein 4

Organism

Bos taurus

Length

250 amino acids

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents (By similarity).

Similarity

Belongs to the recoverin family.

Mass

28.731 kDa

Sequence

MNVRRVESISAQLEEASSTGGFLYTQNSTKRSIKERLMKLLPCSAAKTSSPAVQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEDTFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI

Protein

Kv channel-interacting protein 4: KCNIP4

Gene

KCNIP4

Protein

Kv channel-interacting protein 4

Organism

Homo sapiens

Length

250 amino acids

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.

Similarity

Belongs to the recoverin family.

Mass

28.729 kDa

Sequence

MNVRRVESISAQLEEASSTGGFLYAQNSTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI

Protein

Kv channel-interacting protein 4: KCNIP4

Gene

KCNIP4

Protein

Kv channel-interacting protein 4

Organism

Macaca fascicularis

Length

250 amino acids

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.

Similarity

Belongs to the recoverin family.

Mass

28.729 kDa

Sequence

Protein

Kv channel-interacting protein 4: KCNIP4

Gene

Kcnip4

Protein

Kv channel-interacting protein 4

Organism

Mus musculus

Length

250 amino acids

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3 (PubMed:19109250). Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.

Similarity

Belongs to the recoverin family.

Mass

28.756 kDa

Sequence

MNVRRVESISAQLEEASSTGGFLYAQNNTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI

Protein

Kv channel-interacting protein 4: Kcnip4

Gene

Kcnip4

Protein

Kv channel-interacting protein 4

Organism

Rattus norvegicus

Length

250 amino acids

Function

Similarity

Belongs to the recoverin family.

Mass

28.756 kDa

Sequence

Protein

Kv channel-interacting protein 4: Kcnip4