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K14

Gene
K14
Protein
OX-2 membrane glycoprotein homolog
Organism
Human herpesvirus 8 type P (isolate GK18)
Length
271 amino acids
Function
Dramatically stimulates primary monocytes, macrophages, and dendritic cells to produce the inflammatory cytokines interleukin 1-beta, IL-6, monocyte chemoattractant protein 1, and TNF-alpha. The induction of inflammatory cytokine production potentially promotes the cytokine-mediated angiogenic proliferation of KSHV-infected cells.
Mass
28.783 kDa
Sequence
MSSLFISLPWVAFIWLALLGAVGGARVQGPMRGSAALTCAITPRADIVSVTWQKRQLPGPVNVATYSHSYGVVVQTQYRHKANITCPGLWNSTLVIHNLAVDDEGCYLCIFNSFGGRQVSCTACLEVTSPPTGHVQVNSTEDADTVTCLATGRPPPNVTWAAPWNNASSTQEQFTDSDGLTVAWRTVRLPRGDNTTPSEGICLITWGNESISIPASIQGPLAHDLPAAQGTLAGVAITLVGLFGIFALHHCRRKQGGASPTSDDMDPLSTQ