Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin (By similarity).
Sequence
MPSGLMRANTSTELESILDIVQSSGEIAVVFTSPSIGDLETITSETQRRQLRIAGIPRGGYTILPAIPLYDDELLQMCERYTAASEHEKVEIRNSLYMREYPLFAYSMRNQRALFHPADYVSRILQFCFHYVQVPDEDVLSLQDRSPFLHISPVKEICVHLRLIVRGTPAAPDESESPVPEQLHFHAESDAEKLAAERARALSIAASSGGASETEPLSLFTGVAPSALFQKGAVEEVDLDTEETIEDLTGEETVDAVHSFHSEYLTLSGFELVTKASIFYDHEGEGQRVVAVYIPGGVPKETCRAAAAVLELAVTKKNLRAATNGGLPPDTGIVGYYDYLTNPTQHKCRETEFSRRNWGLFSQSESLLKHLDKLYSQLAPTHHHLQRVAIPSQYQLCGTVFSTITVNRNFRTAVHTDKGDFRSGLGVLSVINGEFEGCHLAIKSLKKAFQLKVGDVLLFDTSLEHGNTEVVHPENHWQRTSIVCYLRTGLMSSVCEMERRKHLNRLILQQLLNTEIRHTTVNINEADSSLPPLFVPTRLASQLAPVQLAALGFIVERTNKQSGCVVAMTMGLGKTLVALTLCFSHLHLAPQADILILTPKPIISHWVDEKNKWGMYGLHFPHFVASDGLNSLEFEQQLLEYERQKNNEKPKAGHVFVINSEYLAGFLRRFRRFTPFLIIVDEGHRVAAKGNKLTESLDRLRCNLRVVLSGTPLQNDASELYRLVGWVNKGVSKVLPPKRFQELANSINQFVEGDDGAFYNAVMAQEYIQDWMRGFVFREMENDLPPLHDYLLVCGSSNVQREYEEKLGLTETAMTALRATEHRPHHLSTHPACYLAFISNCYQSMVSGWTVRAQSNTSRLRTTQLEEIDAMRLEQYAQMIENEQLDAFINVSGKMRVLVDIVLRVQARKEKLIIFSLYVGSQDLIHRTLTALRVCTFTVRGRDSQDRRRRAMHEFSENKDLTVLVLSTKIAAYGLEFTAANHVVLFDSWWNPQADAQAIARAYRRNQRKPVTVYRLISATENKFVLRSQTRKIALFKCIFHKRTTRQALPSELEDCSANETDNERRDFWAKLKATHLVGDTRALLNVYRYQESVRESQ