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JBP2

Gene
JBP2
Protein
Bifunctional helicase and thymine dioxygenase JBP2
Organism
Leishmania braziliensis
Length
1098 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin (By similarity).
Similarity
In the N-terminal section; belongs to the TET family. JBP2 subfamily.
Mass
124.231 kDa
Sequence
MPSGLMRANTSTELESILDIVQSSGEIAVVFTSPSIGDLETITSETQRRQLRIAGIPRGGYTILPAIPLYDDELLQMCERYTAASEHEKVEIRNSLYMREYPLFAYSMRNQRALFHPADYVSRILQFCFHYVQVPDEDVLSLQDRSPFLHISPVKEICVHLRLIVRGTPAAPDESESPVPEQLHFHAESDAEKLAAERARALSIAASSGGASETEPLSLFTGVAPSALFQKGAVEEVDLDTEETIEDLTGEETVDAVHSFHSEYLTLSGFELVTKASIFYDHEGEGQRVVAVYIPGGVPKETCRAAAAVLELAVTKKNLRAATNGGLPPDTGIVGYYDYLTNPTQHKCRETEFSRRNWGLFSQSESLLKHLDKLYSQLAPTHHHLQRVAIPSQYQLCGTVFSTITVNRNFRTAVHTDKGDFRSGLGVLSVINGEFEGCHLAIKSLKKAFQLKVGDVLLFDTSLEHGNTEVVHPENHWQRTSIVCYLRTGLMSSVCEMERRKHLNRLILQQLLNTEIRHTTVNINEADSSLPPLFVPTRLASQLAPVQLAALGFIVERTNKQSGCVVAMTMGLGKTLVALTLCFSHLHLAPQADILILTPKPIISHWVDEKNKWGMYGLHFPHFVASDGLNSLEFEQQLLEYERQKNNEKPKAGHVFVINSEYLAGFLRRFRRFTPFLIIVDEGHRVAAKGNKLTESLDRLRCNLRVVLSGTPLQNDASELYRLVGWVNKGVSKVLPPKRFQELANSINQFVEGDDGAFYNAVMAQEYIQDWMRGFVFREMENDLPPLHDYLLVCGSSNVQREYEEKLGLTETAMTALRATEHRPHHLSTHPACYLAFISNCYQSMVSGWTVRAQSNTSRLRTTQLEEIDAMRLEQYAQMIENEQLDAFINVSGKMRVLVDIVLRVQARKEKLIIFSLYVGSQDLIHRTLTALRVCTFTVRGRDSQDRRRRAMHEFSENKDLTVLVLSTKIAAYGLEFTAANHVVLFDSWWNPQADAQAIARAYRRNQRKPVTVYRLISATENKFVLRSQTRKIALFKCIFHKRTTRQALPSELEDCSANETDNERRDFWAKLKATHLVGDTRALLNVYRYQESVRESQ

Gene
JBP2
Protein
Bifunctional helicase and thymine dioxygenase JBP2
Organism
Leishmania infantum
Length
1098 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin (By similarity).
Similarity
In the N-terminal section; belongs to the TET family. JBP2 subfamily.
Mass
124.115 kDa
Sequence
MLNGLTRVSTSSELESILDIVQSSGEIAVVFTSPSIGDLETITSETQRRQLRIAGIPRGGYTILPAIPLYDDELLQMCERYTSANEYEKAEMRNSLYMREYPLFTYSIRHQRALFHPADYVSRILQFCSYYVQAPDADVLPLQDKSPFLHISPIKEICKHLRLIARGTPVAPDDSESPVPEQLRLHAESDAEKLAAERATAMSIATSSGGASETEQPSLFSGVAPSALFQKGAVEEVDKDAEDTMEDLTGEETVDAVHSFQAEYLTLDGFELVTKASIYYDREGEGQRVVAVYIPGGVPEDTCRAAAAVLEPAATKKNLRAPTNGGLPPDTGIVGYYDYLTNPTQHKCRETEYSRRNWGLLAQSEPLLKHLDKLYSQLAPMHHHLQRVAIPSQYQLCGTVFSTITVNRNFRTAVHTDKGDFRSGLGVLSVINGEFEGCHLAIKRLKKAFQLKVGDVLLFDTSLEHGNTEVVNPEIHWQRTSVVCYLRTGLMSSVCEMERRKHLNRLILLQLLNTEVRNTTVNINGADSSLPPLFVPTRLASHLAPVQLAALGFIVERTEKQSGCVVAMTMGLGKTLVALTLCFSQLHLAPQADILILTPKPIISHWVDEKNKWGMHGLHFPHFVASDGLNSLEFEQQLLEYERQRNNEKPKLGHIFVINGEYLAGFLRRFKRFTPLLMIVDEGHRVAAKGNKLTESLDRLRCNLRIVLSGTPLQNDASELYRLVGWVNKGVSRVLPPKRFQELANDINQFVEGDDGAFYNAVMAQEYIQDWMRGFVFREMENDLPPLHDYLLICGSSDVQREYEEKLGLTETAMTALKATEHRPHHLSTHPACYLAFISDSYQSMVSGWTVRAQSNTSRPRVSQLEEIDTMRLEQYVQLVENEQLDAFIDLSGKMRVLVDIVLRVQARKEKLIIFSLYVGSQDLIHRTLTALRVCTFTVRGRDSQDRRRRAMQEFSENKDLIVLVLSTKIAAYGLDFTAANHVVLFDSWWNPQVDAQAIARAYRRNQRKPVTVYRLISATENKFVLRSQTRKIALFKCILHERTSRQALPDELEDCAANEKDEERRIFWAKLKTTSLAGDSRALLNVYRYQESVRESE

Gene
JBP2
Protein
Bifunctional helicase and thymine dioxygenase JBP2
Organism
Leishmania major
Length
1098 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin (By similarity).
Similarity
In the N-terminal section; belongs to the TET family. JBP2 subfamily.
Mass
124.001 kDa
Sequence
MLNGLTRVSTSSELESILDIVQSSGEIAVVFTSPSIGDLETIASETQRRQLRIAGIPRGGYTILPAIPLYDDELLQMCERYTAANEYEKAEMRNSLYMREYPLFAYSMRHQRALFHPADYVSRILQFCSYYVQAPDADVLSLQDRSPFLHISPIKEICTQLRLIARGTPVAASDSESPVPEQLRLHAESDVEKLAAERATAMSIAASSGGASETEQLSLFSGVAPSALFQKDAVEEVNKDAEDTMEDLTGEETVDAVHSFQAEYLTLDGFELVTKASIFYDREGEGQCIVAVYIPGGVPEDTCRAAAAVLEPAATKKNLRAPTNGGLPPDTGIVGYYDYLTNPTQHKCRETEFSRRNWGLLAQSEPLLKHLDKLYSQLAPMHHHLQRVAIPSQYQLCGTVFSTITVNRNFRTAVHTDRGDFRSGLGVLSVINGEFEGCHLAIKRLKKAFQLKVGDVLLFDTSLEHGNTEVVNPEIHWQRTSVVCYLRTGLMSSVCEMERRKHLNRLILEQLLNTEVRNTTVNINGADSSLPPLFVPTRLASHLAPVQLAALGFIVERTEKQSGCVVAMTMGLGKTLVALTLCFSQLYLAPQADILILTPKPIISHWVDEKNKWGMHGLHFPHFVASDGLNSLEFEQQLLEYERQKNNEKPKSGHIFVINGEYLAGFLRRFKRFTPLVMIVDEGHRVAAKGNKLTESLDRLRCNLRIVLSGTPLQNDASELYRLVGWVNKGVSRVLPPKRFQELANDINQFVEGDDGAFYNAVVAQEYIQDWMRGFVFREMENDLPPLHDYLLICGSSDVQREYEEKLGLTETAMTALKATEHRPHHLSTHPACYLAFISDSYQSMVSGWTVRALSNTSRQRVSQLEEIDTMRLEQYVQLVENEQLDAFIDLSGKMRVLVDIVLRVQARKEKLIVFSLYVGSQDLIHRTLTALRVCTFTVRGRDSQDRRRRAMQEFSENKDLIVLVLSTKIAAYGLDFTAANHVVLFDSWWNPQVDAQAIARAYRRNQRKPVTVYRLISATENKFVLRSQTRKIALFKCILHERTSRQALPDELEDCAANEKDEERRNFWAKLKMTSLAGDTRALLNVYRYQESVRESE

Gene
JBP2
Protein
Bifunctional helicase and thymine dioxygenase JBP2
Organism
Leishmania tarentolae
Length
1098 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin.
Similarity
In the N-terminal section; belongs to the TET family. JBP2 subfamily.
Mass
123.938 kDa
Sequence
MLNGLTRVSTSSELESILDIVQSSGEIAVVFISPSIGDLETITSETQRRQLRIAGIPRGGYTILPAIPLYDDELLQMCERYTAANDYEKAQIRDSLFMREYPLFAYSVRNHKALFHPADYVSRILQFCSYYVQAPDADVLSLLDRSPFLHISPIKEICTHIRLIARGTPLAPEDSESPAPEQLRFHAESDAEKLAAERAGAMSIATSSGGASETEQLSLFSGVVPSALFQKDAVEEVDKDTEETMVDLTGEETVDAVHSFQAEYLTLDGLELVTKAAIFYDREGEGQRIVAVYIPGGVPEDTCRAAAAVLEPAATKKNLRALTNGGLPPDTGLVGYYDYLTNPTRHKCRETEFSRRNWGLLAQSEPLLKHLDKLYSQLAPMHHHLQKVAIPSQYQLCGTVFSTITVNRNFRTAVHTDKGDFRSGLGVLSVINGEFEGCHLAIKKLKKAFQLKVGDVLLFDTSLEHGNTEVINPEIHWQRTSIVCYLRTGLMSSVCEMERRKHLNRLILQQLRNTEVLNTTVNINGADSSLPPLFVPTRLASHLAPVQLAALGFIVERTEKQSGCVVAMTMGLGKTLVALTLCFSQLHLAPQADILILTPKPIISHWVDEKNKWAMHGLHFPHFVASDGLNSLEFEQQLLEYERQKNNEKPKLGHVFVINGEYLAGFLRRFKRFTPLLIIVDEGHRVAAKGNKLTESLDRLRCNLRIVLSGTPLQNDASELYRLVGWVNKGVGRVLPPKRFQELANDINQFVEGDDGAFYNAVMAQEYIQDWMRGFVFREMENDLPPLHDYLLICGSSDVQREYEEKLGLTETTMTALKATEHRPHHLSTHPACYLAFISDSYQSMVSGWTVRAQANTSRMRVSQLEEIDTMRLEHYVQMVENEQLDTFIDLSGKMRVLVDIVLRVQARKEKLIIFSLYVGSQDLIHRTLTALRVCTFTVRGRDSQDRRRRAMQEFSENKDLIVLVLSTKIAAYGLDFTAANHVVLFDSWWNPQVDAQAIARAYRRNQRKPVTVYRLISATENKFVLSSQTRKIALFKCILHERTSRQALPDELEDCAANEKDEERRSFWAKLKTTLLAGGTRALLNVYRYQESVRESE

Gene
JBP2
Protein
Bifunctional helicase and thymine dioxygenase JBP2
Organism
Trypanosoma cruzi (strain CL Brener)
Length
1086 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin (By similarity).
Similarity
In the N-terminal section; belongs to the TET family. JBP2 subfamily.
Mass
122.63 kDa
Sequence
MPVPSHVSVATLQSVLQTVCSTGEPAIIAPSSFLGELDTVVDEVKRHGMKLASIPHGGITILPPVPISGTELFDFCAEYCKAQTHEERLAVRHKINNHNFLMQDPLLRMPCRQLYNPADYVLRIVHLCSELVSASEEEYHGAYGVAPLLHINPVQDVCGKLRSMFQSGSLYVKPWILEEEEERREMDESNRGVLFNSDSFGNGRGGSSISSSERSVDENDVADEDLTGEEVVDNATDTVVEYLSEKDFDVVTESGIFYDDSGERVHAIYLRGGIKKELCQRAAIAIEEAATTKNLRKAVNGGKTNPETGIVGYYDYLNNPTQRKCRETEFTRKNWSSVVDSCEPFLVALNKLYSECAPTHYKLQRIAIPHHYQLFNTVFSTMTVNRNFRTAVHTDRGDFRSGLAALCVIDGVFEGCHLAIKKLGKAFRLETGDVLFFDTSLEHGNTEVHNFDYCWKRVSVVCYLRNGLMSQICEMERRRWLQKQMLKQRLLDRSRQSVINLNATDPNLPPIYLPGRLLEVLSPVQQAALGFVVDRLSKGNGCVIALTMGLGKTLLSLALCYSHMYDQNPRDVLILAPKIVLTHWTGEKQKWEKYGLVFSHFVVSDGTDSVSFEIALKRYKQQLNGELPRTSHVFVINPEYIRTVLKKLTGFRPSLIIVDEGHRVSSKGSKLKDWLEGLRCTARVILSGTPVQNNAEELYRLIGWINSDVHSVLPPRVFTDLAGTINRYINGDDSALAAAVSAQRYIQEWMCSYVFSVMKTDLPPLNDYIIICGFSSIQRKMLEDHFGMEGIDGLTSIKASEHRPYHLSTHPLCFLGFISGVYKSLNGNHKLTPEAEEELESQEYASQLYSLTEDDIGLIDECLSLVNSGFLTEFVGLSGKMTVLISILHSIREKKEKAIIFSQYVGSQDFISRTLTSFDIVSSTIRGRDCHERRRRTIEKFREDEKITCLLLSTQIGAYGLDFTAANHVILWDSWWNPQVESQAIARAYRRNQTRAVIVYRLASEFEDTIVLKTQIRKLALFRCIMNEEASRAVPPEELLDCVDTEEDEGRRFLWRSLKKSYLEGGAPAVSKVFRHGDTVRSESWS

Gene
JBP2
Protein
Bifunctional helicase and thymine dioxygenase JBP2
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Length
1077 amino acids
Function
Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5-hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Probably also acts as a DNA helicase. Recognizes and binds specific regions of the genome, hydrolyzes ATP and allows the DNA base J de novo synthesis. Involved in initial synthesis of DNA base J, JBP1 being able to act via the basal level of DNA base J and propagate further synthesis. In contrast to JBP1, it does not specifically bind DNA base J, it however binds chromatin.
Similarity
In the N-terminal section; belongs to the TET family. JBP2 subfamily.
Mass
121.447 kDa
Sequence
MPMFMDGASQVLQQVLQTVLVTSEPAIVIPGSFLGELDVIVDEAKNHGMKLVSIPKGGITILPPIPMSESSLTRLCKDYYGLKTDAERLALFSNLEETFPTAPGVSLPCRLLYHPRDYICRIVHLCAELVTASDEEYQKAYDIVPLLHIRPVQNVCEELRRQFRAGALTQRLPLGQRVDVQFKRTVVHLDGSMDPFPRNAAEAAVNIAPVALDAVDDIYEGFDVTGTEVVDIPTGKVSEYLSEKDFELVTEDSVLLDPTGKRVQAIFIRGGIDKDICRRAAADVEGVATKQNMRRLTNGGVRNPDTGILGYYDYLNNPTKRKCRMTEFTRRNWGKIIGPCGELLQLLDQLYKENAPDHYELQRRVIPPEYMLFNTVFSTVSVNKNFRTAVHRDKGDFRGGLTALCVLDGNYEGCYLALKSARKAFCLQVGDVLFFDSSLEHGNTEVHNREGSWRRISIVCYLRCGLMSHTCETERSMRLRNQIMSDRLHADSADSVVNLNGVTGHLPPLCIPFKIAKTLSLTQHAALRFVSRRIKEGDGCVLALTMGLGKTLVSLTICYSYIYNNGPCDILIVAPKTLLQHWMQEAKKWKDYGLVFPGFIVLNNVDSSSFEDDLSNYEQQGTTTNPKKSYVFVINPGYIKSFLSRVKGFRPALIVVDEGHCISSKESKLREVLDSLYCSARVVLTGTPVQNNAEELYRLVGWVDDKVHSTLPQRDFNEFSNSINRYVNGDDSAFCDALFAQRYIHEWMSPYVFTVMKVDLPPLHDYIIICNFSAVQQKMFEERIKVDATDNLLCLKASEHRPYHLSTHPLCFLGFLTGIWRTGQVDIEEEPGEFEELGTYRLSRDDDALAKDCSSLLENGKLADFVALSGKLTALISILHSIFEKMEKAVIFSQYIGSQDFIARTLTAYKISVVTIRGKDCQQRRRRVVEMFRDDKNVLCLVVSTQIGAYGLDLTAANHVILWDTWWNPQVESQAIARCYRQNQSKAVIAYKLASGFEDATVLKAQARKRALFKCLINEETSQVVPGHDLVDYTSSEEDDDRRHLWETLKTCTLEGGKPAVTKIIRNIDTVKSERWI