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Irf2

Gene
Irf2
Protein
Interferon regulatory factor 2
Organism
Mus musculus
Length
349 amino acids
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Similarity
Belongs to the IRF family.
Mass
39.453 kDa
Sequence
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGIDKPDPKTWKANFRCAMNSLPDIEEVKDRSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEERVKHIKQEPVESSLGLSNGVSGFSPEYAVLTSAIKNEVDSTVNIIVVGQSHLDSNIEDQEIVTNPPDICQVVEVTTESDDQPVSMSELYPLQISPVSSYAESETTDSVASDEENAEGRPHWRKRSIEGKQYLSNMGTRNTYLLPSMATFVTSNKPDLQVTIKEDSCPMPYNSSWPPFTDLPLPAPVTPTPSSSRPDRETRASVIKKTSDITQARVKSC

Gene
IRF2
Protein
Interferon regulatory factor 2
Organism
Sigmodon hispidus
Length
349 amino acids
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Similarity
Belongs to the IRF family.
Mass
39.471 kDa
Sequence
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGIDKPDPKTWKANFRCAMNSLPDIEEVKDRSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEERVKHIKQEPVESSLGLSNGVSDLSPEYAVLASTIKTEVDSTVNIIVVGQSHLDSNIEDQEIVTNPPDICQVVEVTTESDDQPVSMSELYPLQISPVSSYAESETTDSVPSDEEGAEGRPHWRKRNFEGKQFLSNMGTRSTYLLPSMATFVTSNKPDLQVTIKEESCPMPYNSSWPPFTDLSLPAPVTPTPSSSRPDRETRASVIKKTSDITQSRVKSC

Gene
IRF2
Protein
Interferon regulatory factor 2
Organism
Homo sapiens
Length
349 amino acids
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
Similarity
Belongs to the IRF family.
Mass
39.354 kDa
Sequence
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEDKVKHIKQEPVESSLGLSNGVSDLSPEYAVLTSTIKNEVDSTVNIIVVGQSHLDSNIENQEIVTNPPDICQVVEVTTESDEQPVSMSELYPLQISPVSSYAESETTDSVPSDEESAEGRPHWRKRNIEGKQYLSNMGTRGSYLLPGMASFVTSNKPDLQVTIKEESNPVPYNSSWPPFQDLPLSSSMTPASSSSRPDRETRASVIKKTSDITQARVKSC

Gene
IRF2
Protein
Interferon regulatory factor 2
Organism
Gallus gallus
Length
348 amino acids
Function
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation (By similarity).
Similarity
Belongs to the IRF family.
Mass
39.351 kDa
Sequence
MPVERMRMRPWLEEQINSNTIPGLKWINKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKYQSGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKKTKSEKDDKFKQIKQEPVESSFGINGLNDVTSDYFLSSSIKNEVDSTVNIVVVGQPHLDGSSEEQVIVANPPDVCQVVEVTTESDEQPLSMSQLYPLQISPVSSYAESETTDSVPSDEENAEGRLHWQKKNIEGKQYLSNLGMRNTSHMLPSMATFVANKPDLQVTIKEESCPLPYNSSWPPFPDIPLPQVVSTASTSSSRPDRETRASVIKKTSDITQSRVKSC