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Il34

Gene
IL34
Protein
Interleukin-34
Organism
Homo sapiens
Length
242 amino acids
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Similarity
Belongs to the IL-34 family.
Mass
27.482 kDa
Sequence
MPRGFTWLRYLGIFLGVALGNEPLEMWPLTQNEECTVTGFLRDKLQYRSRLQYMKHYFPINYKISVPYEGVFRIANVTRLQRAQVSERELRYLWVLVSLSATESVQDVLLEGHPSWKYLQEVETLLLNVQQGLTDVEVSPKVESVLSLLNAPGPNLKLVRPKALLDNCFRVMELLYCSCCKQSSVLNWQDCEVPSPQSCSPEPSLQYAATQLYPPPPWSPSSPPHSTGSVRPVRAQGEGLLP

Gene
Il34
Protein
Interleukin-34
Organism
Mus musculus
Length
235 amino acids
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
Similarity
Belongs to the IL-34 family.
Mass
26.764 kDa
Sequence
MPWGLAWLYCLGILLDVALGNENLEIWTLTQDKECDLTGYLRGKLQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLQKAHVSERELRYLWVLVSLNATESVMDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRPKALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPGSLMQCTATNVYPLSRQTPTSLPGSPSSSHGSLP

Gene
Il34
Protein
Interleukin-34
Organism
Rattus norvegicus
Length
234 amino acids
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
Similarity
Belongs to the IL-34 family.
Mass
26.772 kDa
Sequence
MPWGLAWLYCLGILLDVALGNENLEIWTLAQDKECDLTGYLRGKLQYKNRLQYMKHYFPINYRIAVPYEGVLRVANITRLKAHVSERELRYLWVLVSLNATESVLDVLLEGHPSWKYLQEVQTLLENVQRSLMDVEIGPHVEAVLSLLSTPGLSLKLVRPKALLDNCFRVMELLYCSCCKQSPILKWQDCELPRLHPHSPESLMQCAATNVYPLPRQPPTSLPRSPSSNHGPLP

Gene
IL34
Protein
Interleukin-34
Organism
Bos taurus
Length
234 amino acids
Function
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity).
Similarity
Belongs to the IL-34 family.
Mass
26.294 kDa
Sequence
MPQGLAWLRYLGILLGMALGNEGLEPWPLTRSDECAITGFLRDKLQYRNRLQYMKHYFPINYRVSVPYEGVLRTANVTRLQRAQVSQQELRYLWVLVSLSATEWVQEVLLEGHPSWKYLEEVHTLLLDVKQGLGGVEVSPQVEAVLNLLSAPGSLKLVRPKALLDNCFRVMQLLYCPCCKESSVLNWQDCEAPQPQPRSPASAQCEAAQLYPLPQPPSTSLPRVLGPSAGPPTQ