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IVa2

Gene
IVa2
Protein
Packaging protein 1
Organism
Canine adenovirus serotype 1 (strain RI261)
Length
502 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
56.819 kDa
Sequence
MWGGCIQFRISVPGAKIICFKGHHMSRMSIRGQGQVTGKRSCHLHPLLRCAKGLLLCRPAAGLRHLQNQQNEPSQDPHQCADSCPALHSDRNHLNKEAEAMEGQNPTCSRHESAYPIQSQVSKSKKQRNYVDGAAVDDLKNLWDRLQTLQQSLTEMPYAEGLKPLKNFTSFEELLSMGGDSLLNDLLDIQDSITQCCIRASKYLNKEGNCTSLNYYKQPFIAAVYGPTGCGKSQLLRNLMSAQLIVPTPETVFFITPQVDMIPPQEIAAWETQICEGNFLAGPENTVVPQSGSIMPRFIQMSYAQLTKDENYDVTSPNNIFANAASKGPIAIVMDECMEDLGGNRGIAKFFHAFPSKLLDRFPKCTGYSVIVVLHNMNPRRDQGGNIANLKIQAKVHMISPKVHPSQLNRFINIYTKGQPTAISLLLKDIFNYHRLNTNFDWIVYNTEPIDNCMHWMYLSPQEGLIPMYLNIQGKLYQALERIHRTLTDRQRWTRYYHSKKK

Gene
IVa2
Protein
Packaging protein 1
Organism
Human adenovirus A serotype 12
Length
452 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
51.545 kDa
Sequence
MLPCRSTGRRHALQHQPPQFKAHTGQRSTRSASIHRDRNNPDAHITSLEGQNPRPFGCSPPRSLQQQPAKPPQRGSLLDRDGIENITELWDRLQLLKQTLDHMPMADGLKPLKNFKSLQELLSLGGERLLGELAKQNIRVRQMMNEVAPLLHEDGSCTSLNYHLQPVIGVIYGPTGCGKSQLLRNLLSAQLVTPAPETVFFIVPQVDMIPPSEIKSWEMQICEGNYVPGPEGTIIPQSGTLCPKFVKLSYDDLTLDHNYDVSDPENIFAQAAARGPIAIIMDECMENLGSHKGVSKFFHAFPSKLHDKFPKCTGYTVFVVLHNMNPRRDLAGNIANLKIQSKLHIMSPRMHPTQLNRFINTYTKGLPLAISLLLKDIFNHHAQRCCYDWIIYNTNPEHEALQWSYLHPKDGLMPMYLNIQAHLYKILEHIHRVLNDRERWSRAYHVRKNKYQ

Gene
IVa2
Protein
Packaging protein 1
Organism
Human adenovirus C serotype 2
Length
449 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
50.881 kDa
Sequence
METRGRRPAALQHQQDQPQAHPGQRAARSAPLHRDPDYADEDPAPVERHDPGPSGRAPTTAVQRKPPQPAKRGDMLDRDAVEHVTELWDRLELLGQTLKSMPTADGLKPLKNFASLQELLSLGGERLLAHLVRENMQVRDMLNEVAPLLRDDGSCSSLNYQLQPVIGVIYGPTGCGKSQLLRNLLSSQLISPTPETVFFIAPQVDMIPPSELKAWEMQICEGNYAPGPDGTIIPQSGTLRPRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIANLKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAISLLLKDIFRHHAQRSCYDWIIYNTTPQHEALQWCYLHPRDGLMPMYLNIQSHLYHVLEKIHRTLNDRDRWSRAYRARKTPK

Gene
IVa2
Protein
Packaging protein 1
Organism
Human adenovirus C serotype 5
Length
449 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
50.887 kDa
Sequence
METRGRRPAALQHQQDQPQAHPGQRAARSAPLHRDPDYADEDPAPVERHDPGPSGRAPTTAVQRKPPQPAKRGDMLDRDAVEQVTELWDRLELLGQTLKSMPTADGLKPLKNFASLQELLSLGGERLLADLVRENMRVRDMLNEVAPLLRDDGSCSSLNYQLHPVIGVIYGPTGCGKSQLLRNLLSSQLISPTPETVFFIAPQVDMIPPSELKAWEMQICEGNYAPGPDGTIIPQSGTLRPRFVKMAYDDLILEHNYDVSDPRNIFAQAAARGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDMAGNIANLKIQSKMHLISPRMHPSQLNRFVNTYTKGLPLAISLLLKDIFRHHAQRSCYDWIIYNTTPQHEALQWCYLHPRDGLMPMYLNIQSHLYHVLEKIHRTLNDRDRWSRAYRARKTPK

Gene
IVa2
Protein
Packaging protein 1
Organism
Murine adenovirus A serotype 1
Length
449 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
50.589 kDa
Sequence
MESRGKHRLKKNGESKENLGEHEQARIGFHRNGDSADSLSSPVAEPNFSSPGGRSSNSILHCPPQSPEQGNNLDCLVGEELQFLWPRLQCLQHTLSNLPLSEGLKPLMNFETVEDLAALAGKGLLQELKHDYEILCKSLNSAAPLLSPEGNCESLNYSLQPLIAIVYGPTGSGKSQLLRNLLSCHLIDPSPETVFFVVPQIDMIPPQEMSAWNAQLVEGNYTCGPQQTIVPKSGTLKPRLITLTYDDLTADHNYDVTHPQNIFAQAAQRGPICIIVDECMEELGKHKSIAKFFHAFPSKLHDRFPQCTGYSVFVVLHNMNPRKDQAGNIATLKIQSKCHIISPKMQPSQVARFINTYTKAMPTAITLLLKDIFHHNANHINYDWIIYNTSPEHECMQWMYLHPQNGLMPMYLNVQTILYQLLEKIDKVLRQRQRWNTAYSKKCDKLANK

Gene
IVa2
Protein
Packaging protein 1
Organism
Human adenovirus B serotype 7
Length
448 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
50.678 kDa
Sequence
METKGRRSAAVLDQQDESEAHPRKRPTRRAPLHRDGNNPDSDAATMEGSDPGSAGRPSSDSLLQEPSQPAKRGGLLDRDAIEHITELWDRLELLQQTLSKMPMADGLKPLKNFSSLQELLSLGGERLLTDLVRENIHVREMMNEVAPLLREDGSCRSLNYHLQPVIGVIYGPTGCGKSQLLRNLLSSQLITPAPETVFFIAPQVDMIPPSELKAWEMQICEGNYAPGPQGTFIPQSGTLRPKFIKMAYDDLTQEHNYDVSDPRNVFARAAAHGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDLGGNIANLKIQSKMHIISPRMHPSQLNRFVNTYTKGLPVAISLLLKDIVQHHALRPCYDWVIYNTTPEQEALQWSHLHPRDGLMPMYLNIQSHLYRVLEKIHRVLNDRNRWSRAYRARKIK

Gene
IVa2
Protein
Packaging protein 1
Organism
Human adenovirus F serotype 40
Length
446 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
51.122 kDa
Sequence
METRGRRRAFSHQQDEPEENPGKRPTRSAPLYRHRNQPNANPATLERHYPCSTGRPPTGTVQPKPSQPPQPRSLLDRDAIDHITELWDRLYLLRQSLEKMTMADGLKPLKHFRSLEELLSLGGERLLQDLVKENQHVRSMMNEVTPLLREDGSCISLNYQLQPVIGVIYGPTGCGKSQLLRNLLSTQLINPPPETVFFIAPQVDMIPPSEIKAWEMQICEGNYAPGPEGTIIPQSGTLLPRFIKMAYDELTLEQNYDVSHPDNIFAKAASQGPIAIIMDECMENLGGHKGVSKFFHAFPSKLHDKFPKCTGYTVLVVLHNMNPRRDLGGNIANLKIQAKMHLISPRMHPSQLNRFVNTFTKGLPLAISLLLKDIFQFHAQKPCYDWIIYNTTPEHDALQWSYLHPRDGLMPMYLNIQAHLYRVLENIHKVLNDRDRWSRAYRKRNK

Gene
IVa2
Protein
Packaging protein 1
Organism
Canine adenovirus serotype 1 (strain CLL)
Length
446 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
50.721 kDa
Sequence
MEEKAGLRHLQNQQNEPSQDPHQCADPCPALHSDRNHLNKEAEAMEGQNPTCSRHESAYPIQSQVSKSKKQRNYVDGAAVDDLKNLWDRLQTLQQSLTEMPYAEGLKPLKNFTSFEELLSMGGDSLLNDLLDIQDSITQCCIRASKYLNKEGNCTSLNYYKQPFIAAVYGPTGCGKSQLLRNLMSAQLIVPTPETVFFITPQVDMIPPQEIAAWETQICEGNFLAGPENTVVPQSGSIMPRFIQMSYAQLTKDENYDVTSPNNIFANAASKGPIAIVMDECMEDLGGNRGIAKFFHAFPSKLLDRFPKCTGYSVIVVLHNMNPRRDQGGNIANLKIQAKVHMISPKVHPSQLNRFINIYTKGQPTAISLLLKDIFNYHRLNTNFDWIVYNTEPIDNCMHWMYLSPQEGLIPMYLNIQGKLYQALERIHRTLTDRQRWTRYYHSKKK

Gene
IVa2
Protein
Packaging protein 1
Organism
Canine adenovirus serotype 2 (strain Toronto A 26-61)
Length
446 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
50.392 kDa
Sequence
MEEKAGLGRLQNQQDEPAQDPHQRAGPRATFHSDRNHPNKEAEAMEGQNPACSRHASSHSIQPQASKPKKHRNYLDGAAVDDLKSLWDRLQTLQQSLTNMPYAEGLKPLKNFASFEELLSMGGDSLLNDLLDIQDSITQCCMKVSKYLNKDGSCASLNYYKQPFIAAVYGPTGCGKSQLLRNLMSAQLIVPAPETVFFITPQVDMIPPQEIAAWETQICEGNFLAGPENTVVPQSGSIMPKFVQMSYAELTNEANYDVTNPTNVFARAASKGPLAIVMDECMEDLGGNRGIAKFFHAFPSKLLDRFPKCTGYSVIVVLHNMNPRRDQGGNIANLKIQAKMHIISPKVHPSQLNRFINIYTKGQPTAISLLLKDIFNYHRLNTNFDWIVYNTEPIDNCMHWLYLSPDEGLIPMYLNIQAKVYQAMERIHRTITDRQRWTRYYHSKKK

Gene
IVa2
Protein
Packaging protein 1
Organism
Snake adenovirus serotype 1
Length
443 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
49.956 kDa
Sequence
MSGAADGTVPVGEDTHQEDSGERECEQRPVHSGREATGESDPALERPDHGERHGPEPRFPSFSVRPEAAQPPPSRTIARESFLGRFITDCLKWKNDVVKIDPNICKDPFPSDDEIFGNIGSHSTLLRELHECAYRYQKAVNASHPLLQRDGSLKTLNYGVQPFIVTVYGPTGSGKSQFLRNVISSKMIDPPPETVFFVTPEKGTVTNEEKLSWEAQCAEGVYNSKCVPITKTFQPAFVNLSFSEAVDEENLSIDSPNNVFVQAAKKGPICIIIDECMNQLGACRSISSFFHALPSKIFGRFPACTGYTVLVVLHNMNPRSDRGNIKDLKIQSKCHIISPQLESQQVSRFIKNFSFGFPTPLVSVIKDIVDHAKMHSKFSWLVYCSVPVRESFRWSYYSPEDQLTPLYVDLQAVMYEACHNIRRVFCKRLYSRVSYANKRKWYD

Gene
IVa2
Protein
Packaging protein 1
Organism
Fowl adenovirus A serotype 1 (strain CELO / Phelps)
Length
439 amino acids
Function
Component of the packaging machinery which encapsidates the viral DNA into preformed capsids and transcriptional activator of the viral major late promoter (MLP). Binds, along with packaging proteins 2 and 3, to the specific packaging sequence on the left end of viral genomic DNA and displays ATPase activity thereby providing the power stroke of the packaging machinery. The activity of packaging protein IVa2 is stimulated by protein 33K which acts as a terminase. May be the protein that pumps DNA into the capsid powered by ATP hydrolysis. Specifically binds to the 5'-CG-3' nucleotides of the repeats making up the packaging sequence. Component of the DEF-A and DEF-B transcription factors that bind downstream elements of the major late promoter (MLP), and stimulate transcription from the MLP after initiation of viral DNA replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-B is a homodimer of packaging protein 1.
Similarity
Belongs to the adenoviridae packaging protein 1 family.
Mass
50.369 kDa
Sequence
MSTQIPARQETYDPSQSSGTKTPSHPYDGNPTRSYPKRNAGKFTTYSSQMIAPRKRKAWEYEEEEYEASRDFYQRVTSWYDGAVDLAPQLFREQHFPSYDEFYSLGGVNEKFLEAHEEVKAQEQMDSRYLQHGQLPSINMGKQPIIGVIYGPTGSGKSHLLRALISCNMLDPIPETVIFITPEKNMIPPIEQTSWNLQLVEANFDCREDGTIAPKTSTFRPEFMEMTYEEATAPEHLNIDHPDNIYVKVSKRGPVAIIMDECMDKLCSGSSVSVLFHALPSKLFARSAHCTAFYIFVVLHNMAPRTAIGNVPTLKVNAKMHILSCHIPQFQFARFLYAFAHNISKDLVVLLKAYFSFLQQNQRFSWVMYTPDPVSESFRWCSIDQQYSIIPLNVNIQERFLKTAKSIIKFSETHRKQLERNPKLTDLEKLSPPGTFQET