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ITGA4

Gene
Itga4
Protein
Integrin alpha-4
Organism
Mus musculus
Length
1039 amino acids
Function
Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1.
Similarity
Belongs to the integrin alpha chain family.
Mass
115.696 kDa
Sequence
MFSTKSAWLRNGGADQGPRGIALREAVMLLLYFGVPTGPSYNLDPENALLYQGPSGTLFGYSVVLHSHGSKRWLIVGAPTASWLSNASVVNPGAIYRCGIRKNPNQTCEQLQSGSPSGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYMKSDNKLPTGICYVMPSDLRTELSKRMAPCYKDYTRKFGENFASCQAGISSFYTQDLIVMGAPGSSYWTGTVFVYNITTNQYKAFVDRQNQVKFGSYLGYSVGAGHFRSPHTTEVVGGAPQHEQIGKAYIFSIDENELNIVYEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGMGAVMVEMERVLVGSDKYAARFGESIANLGDIDNDGFEDIAIGAPQEDDLRGAVYIYNGRVDGISSTYSQRIEGQQISKSLRMFGQSISGQIDADNNGYVDVAVGAFQSDSAVLLRTRPVVIVEASLSHPESVNRTKFDCTENGLPSVCMHLTLCFSYKGKEVPGYIVLFYNVSLDVHRKAESPSRFYFFSNGTSDVITGSIRVSSSGEKCRTHQAFMRKDVRDILTPIHVEATYHLGHHVITKRNTEEFPPLQPILQQKKEKDVIRKMINFARFCAYENCSADLQVSAKVGFLKPYENKTYLAVGSMKTIMLNVSLFNAGDDAYETTLNVQLPTGLYFIKILDLEEKQINCEVTESSGIVKLACSLGYIYVDRLSRIDISFLLDVSSLSRAHEDLSISVHASCENEGELDQVRDNRVTLTIPLRYEVMLTVHGLVNPTSFVYGSSEENEPETCMAEKLNLTFHVINTGISMAPNVSVKIMVPNSFLPQDDKLFNVLDVQTTTGQCHFKHYGRECTFAQQKGIAGTLTDIVKFLSKTDKRLLYCMKADQHCLDFLCNFGKMESGKEASVHIQLEGRPSILEMDETSSLKFEIKATAFPEPHPKVIELNKDENVAHVFLEGLHHQRPKRHFTIIIITISLLLGLIVLLLISCVMWKAGFFKRQYKSILQEENRRDSWSYVNSKSNDD

Gene
ITGA4
Protein
Integrin alpha-4
Organism
Homo sapiens
Length
1032 amino acids
Function
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
Similarity
Belongs to the integrin alpha chain family.
Mass
114.9 kDa
Sequence
MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD

Gene
itga4
Protein
Integrin alpha-4
Organism
Xenopus laevis
Length
1032 amino acids
Function
Fibronectin and V-CAM adhesion receptor.
Similarity
Belongs to the integrin alpha chain family.
Mass
115.215 kDa
Sequence
MIRDLGKVGKVSLLLDHIWTGILLYTVILTPADCYNIDESSPMLFKGSPGSLFGFSVVLHSNGEGNWIVVGAPQSSWTTKNVSNPGAILKCKIQQNPNRTCDGLELGNQNGAKCGKTCKEEQDNQWLGVSLSRQPTKDGQILACGHRWKNTHFMLSDHKLPYGVCYGIPADFRTELSKRICPCYKDHVRKFGDRYGSCQAGISTFYVEDVIIMGAPGSFYWTGSIFVYNTTENTIKSYVDLNNAVKFGSYLGYSVGAGHFRTPNGYDVIGGAPQQEQTGRVYIFTYEEKQLTILFEAGGKKLGSYFGAAVCAADLNGDGLSDLLVGAPIQSTIREEGRVFVYMNTGSGAMEELKFELSGSDLYAARFGETIANLGDIDNDGFEDVAIAAPQEGDLEGAVYIYNGREKGITPSFSQRLQGSKFGYGLRMFGQSLSNVLDIDGNGYQDVAIGAFLSDSAVLLRTRPVIIIDAFLKLPSTVNKTKFECMENGVAVVCMNVTVCFAYQGLDVPGYIVMFYNITSDVRRKSGTPARFYFVSNGSSDVISGTVEIRQKSANCKTHQAFMRKDTRDIFTPIHMESSYYLGKHIVSKRSADDFQPLQPVLQQKEGKGNVITNKVYFARYCNLPNCSADLQITGKRSFPKPFESKTYLAVGGMKSLMINITLFNGGDDAFQTVLRLRLPKGLYFVKVFDLLEKEINCAVNKEENEQTRLDCSVGHFYVDAFSKQEFSFLLDSSALIRAEEDLVINATVACANELIQDTMWNNEVSFIVPTRYEIDLNVLGTVSPFSFVFGPREDKPDDSCIMEEIEYTFNVINAGSSLVPAAKLQISLPNTFAPNDIKLFNILAVKTTVGECYFDNSTRDCETPKNTRSKIGDLFAFFSRPDKRWLYCIKDDPSCLQILCLFGDMERESKATVEVQLEISHSHLERDEAMLIQFFTTAQAGFEDSFKIINLNQDHHAYVVLEALHNLKPKKHVIYMIIGISLLLGILLFSLLTYILWKVGFFRRKYQPIGTEETSRRESWNYLNKDEKEVK