Protein
Immunity-related GTPase family M protein
Organism
Rattus norvegicus
Function
Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Similarity
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
Sequence
MKPSHKSCEAAPLLPKMPETSTHNAPLNLSFPSVPSYQIGCSSLPEISRSTERALKEGKLPELVYGVKETVATLSQIPVSIFVTGDSGNGMSSFINALRIIGHEEDASAPTGVVRTTQTRAEYSSSHFPNVVLWDLPGLGATAQTVENYIEEMKFSTCDLFIIVASEQFSSNHVKLAKIIQSMGKRFYVIWTKLDRDLSTSVLSEVRLIQNIQENIRENLQKEGVKEVPIFLVSNLDPLLHDFPELRNTLQTDLSNIRCCEPLKTLYVIYEKIIGDKVANWNQIIANGRLKSSLGVRDDDDMGECLKRYRLIFGIDDESLQQIAHGMGTVVMEYKANIKSQDFHTLRRADWKLRLMTCTTVNALFCLFKFLPCLCHCFKRMRHKRMLLLVAKDTKNILKKILMDAVSPPQI