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IRGM

Gene
Irgm
Protein
Immunity-related GTPase family M protein
Organism
Rattus norvegicus
Length
411 amino acids
Function
Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Similarity
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
Mass
46.338 kDa
Sequence
MKPSHKSCEAAPLLPKMPETSTHNAPLNLSFPSVPSYQIGCSSLPEISRSTERALKEGKLPELVYGVKETVATLSQIPVSIFVTGDSGNGMSSFINALRIIGHEEDASAPTGVVRTTQTRAEYSSSHFPNVVLWDLPGLGATAQTVENYIEEMKFSTCDLFIIVASEQFSSNHVKLAKIIQSMGKRFYVIWTKLDRDLSTSVLSEVRLIQNIQENIRENLQKEGVKEVPIFLVSNLDPLLHDFPELRNTLQTDLSNIRCCEPLKTLYVIYEKIIGDKVANWNQIIANGRLKSSLGVRDDDDMGECLKRYRLIFGIDDESLQQIAHGMGTVVMEYKANIKSQDFHTLRRADWKLRLMTCTTVNALFCLFKFLPCLCHCFKRMRHKRMLLLVAKDTKNILKKILMDAVSPPQI

Gene
IRGM
Protein
Immunity-related GTPase family M protein
Organism
Homo sapiens
Length
181 amino acids
Function
Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Similarity
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
Mass
20.142 kDa
Sequence
MEAMNVEKASADGNLPEVISNIKETLKIVSRTPVNITMAGDSGNGMSTFISALRNTGHEGKASPPTELVKATQRCASYFSSHFSNVVLWDLPGTGSATTTLENYLMEMQFNRYDFIMVASAQFSMNHVMLAKTAEDMGKKFYIVWTKLDMDLSTGALPEVQLLQIRENVLENLQKERVCEY