IPPK

Inositol-pentakisphosphate 2-kinase

491 amino acids

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.

Belongs to the IPK1 type 2 family.

56.017 kDa

MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV

Ippk

Inositol-pentakisphosphate 2-kinase

489 amino acids

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.

Belongs to the IPK1 type 2 family.

55.928 kDa

MEEGKMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKKKTSEEILQHLQNIVDFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPESRCDKDLDTFSGYAMCLPNLTRLQTFHFAEHRPILCVEIKPKCGFIPFSNDVTHEMKHKVCRYCMHQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALRSLLQETQNNLRIFKNGELIYGCGDARSPVADLKELAHHLKPFFFPSNGLASGPHCTKAVIRELVHVITRVLLSSSEKARAGALRLGLQGPRVCEASPFSRSLHNQGKNTSEHSGLPKGCLLYKTLQVQMLDQLDIEGLYPLYKRVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQGTSSDQRPVIPSSRSRLAFSVSVLDLDLKPYESIPHQYKLDSKIVNYYSKTVHAKDDTVRSTRFKEHEDCTLVLHKV

Ippk

Inositol-pentakisphosphate 2-kinase

489 amino acids

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.

Belongs to the IPK1 type 2 family.

55.634 kDa

MEEGKMDENEWSYHGEGNKSLVVAHAQRCVVLRFLKFPPNKKKTSEEILQHLQNIVDFGKNVMKDFLGENYVHCGEVVQLPLEFVKQLCLKIQCERPESRCDKDLDTLSGYAMCLPNLTRLQTFPFAEHRPILCVEIKPKCGFIPFSNGVTHEMKHKVCRYCMHQHLKVATGKWKKISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLRIFKNGELIYGCADARSPVADLKALAHHLKPFFFPSNGLASGPQCTRAVIRELVHVITRVLLSTSDKGRAGALRLGLQGARVCEASPFSRSLHHQGKNTPEHSGLPKGCLLYKTLQVQMLDQLDIEGLYPLYNRVEQYLEEFPEERKTLQIDGPYDEVFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQGASSDQRPVIPSSRSRLAFSVSVLDLDLKPYESIPHQYKLDSKIVSYYSKTVHAKDDTVRSTRFKEHEDCTLVLHKV

ippk

Inositol-pentakisphosphate 2-kinase

483 amino acids

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis and ion channel regulation. InsP6 also acts as a key regulator of left-right asymmetry in embryo, probably by regulating asymmetric Ca(2+) during left-right specification.

Belongs to the IPK1 type 2 family.

56.028 kDa

MELDKMDENDWKYHGEGNKSIVVSHLRHCQVLRLLKVPSEDSAHTRQTAEQTLRHILNIMDYSKHVMKPLLGEKYVHSGEVVRLPLDFLRQMSLKVQQERPELRCDKVMDTFSGCGLCLPDLTQLPLHHLRDHRPPICVEIKPKCGFLPFSRHMTKECKWKVCRFCMHQHYKLANGKWKRLSRYCPLDLFSGSKQRMYVALKNLLEEPQNNLKIFKGGELIFSCKDDAKQQPDLNNLIQHLRPYFPHTNGLYNGHQPGKVILNEFIQVICSALLSGGDSNRSGEPRKMHLSESKPHCEASPFPRDLIRNGHHGLPKDSVLAKILQVQMLDNLDIEGIYPLYKRVEQYLEEFPKERIRLQIDGPYDESFMDTVKSCLNEDDGSVEYAIGKVHQYRVAMTAKDCSVMITFAPCEEDEEHKLNLEKPRFTYSVSILDLDTKPYEGIPHQYKLDSKIVNYYLRSTQAPPPSSLYKERQECTLLFHAV