intu

Protein inturned

953 amino acids

Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Required for ciliogenesis by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Proposed to function as core component of a functional module called CPLANE (ciliogenesis and planar polarity effectors) involved in recruitment of peripheral IFT-A proteins to basal bodies. Controls the localization of both rhoa and disheveled in multi-ciliated cells. Has an indirect effect on hedgehog signaling (By similarity).

Belongs to the inturned family.

106.422 kDa

MDYTRGVSVEAAEEEEERRGWDSHSAGTCSSSYTDCSSCCSSDLEPEWLDRVQKNGELFYLELSEGEEEILLPLSPLEPVGVNHVRFNDSEAEILSEERKNVGKNSEPRFRKLAKMLKKKHTSKKGSAGLNGPTCPTSILKQHSSQKAGIIVRYQYRDTCLYVNPDRLPEGEPKEKSNLLQALIGIVHQSSRNSKRIERQGSQEASQRLSNQEKLVVHGFIPGSPAIRCGQILIGDTLVAVNDVEVHVENIERVLSCIPGPTQVKLTFETPVLCSGTALQNQSTQVQTSINDLAALVWGDEHANSQQDLQRMSHIVMYLTLRLDSDTSKEEQEIIYQYPVSEASHKLKSIRGLFLTLSDMLQNVTGAPIISSSLILNDELVHVSYWKENDKLLLISVPAQRFPLLQLKNMTADIVRTLKFMYSTLDRAFCQAENISRLDHFFSLFFQRALRVFSLTGIAGYGSQFYDACSSLLVENLPGVRWLSLPEDIKMEIDTVLSDLEALDFAELSEDFYEMRRLYMIIGTCLFYKGYLLSNHLPKEDLVDVAIYCRQYCLLTLASERIGQLIIWREVYPQYHLKQCGSSATEECTEPGGRYFLLIVGLRHFMLCTLLEAGGCTSKATGHPGPDYIYVDQVKATLLQLEMLDMSIEDRLSSAPNPCLSCADWFLPSTRDKLGNFTNSAVLSKLQTPPKKAPSPVSKRRLFAEAASSLRTRRPSPTRSSGGSDSGTDGAGESVGVVTHSTPDMARKFGRRESLGSGGSDGSGGSGSLLKINKKKYSLPNPFSSGSLRKNLSERETDDIYNTIKLTSGPENTLFHYLYFETLQGVFISPTHKEVEQLGGSIHPQLIKNFHRCCLSIHSVFQQALNQKNSKQSDSVACMDVAGFGPIKEHGVLFECSPENWNDQKKSPPTMSYWVVGRLFMQPQPQELYVCFHDSVTEISVELAFKLSFGMPL

intu

Protein inturned

953 amino acids

Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Required for ciliogenesis by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Proposed to function as core component of a functional module called CPLANE (ciliogenesis and planar polarity effectors) involved in recruitment of peripheral IFT-A proteins to basal bodies. Controls the localization of both rhoa and disheveled in multi-ciliated cells. Has an indirect effect on hedgehog signaling (By similarity).

Belongs to the inturned family.

106.422 kDa

MDYTRGVSVEAAEEEEERRGWDSHSAGTCSSSYTDCSSCCSSDLEPEWLDRVQKNGELFYLELSEGEEEILLPLSPLEPVGVNHVRFNDSEAEILSEERKNVGKNSEPRFRKLAKMLKKKHTSKKGSAGLNGPTCPTSILKQHSSQKAGIIVRYQYRDTCLYVNPDRLPEGEPKEKSNLLQALIGIVHQSSRNSKRIERQGSQEASQRLSNQEKLVVHGFIPGSPAIRCGQILIGDTLVAVNDVEVHVENIERVLSCIPGPTQVKLTFETPVLCSGTALQNQSTQVQTSINDLAALVWGDEHANSQQDLQRMSHIVMYLTLRLDSDTSKEEQEIIYQYPVSEASHKLKSIRGLFLTLSDMLQNVTGAPIISSSLILNDELVHVSYWKENDKLLLISVPAQRFPLLQLKNMTADIVRTLKFMYSTLDRAFCQAENISRLDHFFSLFFQRALRVFSLTGIAGYGSQFYDACSSLLVENLPGVRWLSLPEDIKMEIDTVLSDLEALDFAELSEDFYEMRRLYMIIGTCLFYKGYLLSNHLPKEDLVDVAIYCRQYCLLTLASERIGQLIIWREVYPQYHLKQCGSSATEECTEPGGRYFLLIVGLRHFMLCTLLEAGGCTSKATGHPGPDYIYVDQVKATLLQLEMLDMSIEDRLSSAPNPCLSCADWFLPSTRDKLGNFTNSAVLSKLQTPPKKAPSPVSKRRLFAEAASSLRTRRPSPTRSSGGSDSGTDGAGESVGVVTHSTPDMARKFGRRESLGSGGSDGSGGSGSLLKINKKKYSLPNPFSSGSLRKNLSERETDDIYNTIKLTSGPENTLFHYLYFETLQGVFISPTHKEVEQLGGSIHPQLIKNFHRCCLSIHSVFQQALNQKNSKQSDSVACMDVAGFGPIKEHGVLFECSPENWNDQKKSPPTMSYWVVGRLFMQPQPQELYVCFHDSVTEISVELAFKLSFGMPL

intu

Protein inturned

951 amino acids

Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Required for ciliogenesis by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Proposed to function as core component of a functional module called CPLANE (ciliogenesis and planar polarity effectors) involved in recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Controls the localization of both rhoa and disheveled in multi-ciliated cells. Has an indirect effect on hedgehog signaling.

Belongs to the inturned family.

106.835 kDa

MEHSRGDSVEAGEEEEGRGGWDSRSAGTFSSSCTDCSSYCSSDLEPEWLDRVQKNGELFYLELSEGEEEILLPLSPLEPVGVNHVRFSDNEAEILPEDRKNVRKNSEPRFRKLAKMLKKKNNKKGSAELNRQACPTSILKQNSRQKPGIIVHYQYRDTCLYVNPDHLPEDEHKKTSNLLQALIGIVHQSSRNSKRSERQGRQESNQRLSNQEKLVVHGFIPGSPAIRCGQVLIGDTLVAVNDVEVHVENIERVLSCIPGPMQLKLTFETPVLYSGMGLKNQNNQAQTSINDLASLVWGDEHTNSQQDLQHMPHIVMYLTLRLDSETSKEEQEILYQYPVSDASHKLKSIRGLFLTLGDMLQNVTGAPIVSSSLILNGELVHVSYWKENDKLFLISVPAQRFPLLQLKNVTADLVRTLKFMYSTLDRAFCQAENISRLDHFFSLFFQRVLRVFLLSGITGYGPQFYDACSSLLVENLPGVRWLSLPEDIKIQIDTVLSDLEALDFAELSEDYYEMRRLYMIIGTCIFYKGYLLSNHLPKEDLVDVVLYCRQYCLLALASERIGQLIIWREVYPRYHLKHCGSPATEECSEPGGRYFLLIVGLKHFMLCTLLEAGGCTSKATGNPGPDYIYVDQVKATLLQLEMLDLNLEERLGSAPNPCLSCADWFLPSARDKLGNFTSSIVLNKLQTPKRTTSPVSKRRLFAEAASSLRTRRPSPTRSSGGSDSGTDGAGESVGVITHSSPDMARKFGRRESLGSGGSDGSGGSGTLLKINKKKYSLPNPFSSASLRKNLSERETDDIYNTIKLTSGPENTLFHYLYFETLQGVFISPTHKEVEQLGGSIHPQLIKNFHRCCLSIRSVFQQALNKKNSKHSDSKACVDVAGFDPIKEHGVLFECSPENWNDQKKSPPTMSYWVVGRLFMHPQPQELYVCFHDSVTEISVELAFKLSFGIPL

intu

Protein inturned

951 amino acids

Plays a role in the definition of cell polarity via the planar cell polarity (PCP) cascade. Required for ciliogenesis by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Proposed to function as core component of a functional module called CPLANE (ciliogenesis and planar polarity effectors) involved in recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). Controls the localization of both rhoa and disheveled in multi-ciliated cells. Has an indirect effect on hedgehog signaling.

Belongs to the inturned family.

106.835 kDa

MEHSRGDSVEAGEEEEGRGGWDSRSAGTFSSSCTDCSSYCSSDLEPEWLDRVQKNGELFYLELSEGEEEILLPLSPLEPVGVNHVRFSDNEAEILPEDRKNVRKNSEPRFRKLAKMLKKKNNKKGSAELNRQACPTSILKQNSRQKPGIIVHYQYRDTCLYVNPDHLPEDEHKKTSNLLQALIGIVHQSSRNSKRSERQGRQESNQRLSNQEKLVVHGFIPGSPAIRCGQVLIGDTLVAVNDVEVHVENIERVLSCIPGPMQLKLTFETPVLYSGMGLKNQNNQAQTSINDLASLVWGDEHTNSQQDLQHMPHIVMYLTLRLDSETSKEEQEILYQYPVSDASHKLKSIRGLFLTLGDMLQNVTGAPIVSSSLILNGELVHVSYWKENDKLFLISVPAQRFPLLQLKNVTADLVRTLKFMYSTLDRAFCQAENISRLDHFFSLFFQRVLRVFLLSGITGYGPQFYDACSSLLVENLPGVRWLSLPEDIKIQIDTVLSDLEALDFAELSEDYYEMRRLYMIIGTCIFYKGYLLSNHLPKEDLVDVVLYCRQYCLLALASERIGQLIIWREVYPRYHLKHCGSPATEECSEPGGRYFLLIVGLKHFMLCTLLEAGGCTSKATGNPGPDYIYVDQVKATLLQLEMLDLNLEERLGSAPNPCLSCADWFLPSARDKLGNFTSSIVLNKLQTPKRTTSPVSKRRLFAEAASSLRTRRPSPTRSSGGSDSGTDGAGESVGVITHSSPDMARKFGRRESLGSGGSDGSGGSGTLLKINKKKYSLPNPFSSASLRKNLSERETDDIYNTIKLTSGPENTLFHYLYFETLQGVFISPTHKEVEQLGGSIHPQLIKNFHRCCLSIRSVFQQALNKKNSKHSDSKACVDVAGFDPIKEHGVLFECSPENWNDQKKSPPTMSYWVVGRLFMHPQPQELYVCFHDSVTEISVELAFKLSFGIPL

INTU

Protein inturned

942 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).

Belongs to the inturned family.

105.648 kDa

MASVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQKNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEDDYKERKKYEPKLKQFTKILRRKRLLPKRCNKKNSNDNGPVSILKHQSNQKTGVIVQQRYKDVNVYVNPKKLTVIKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQSGLNTPHIIMYLTLQLDSETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGTQVTSSSLLLNGKQIHVAYWKESDKLLLIGLPAEEVPLPRLRNMIENVIQTLKFMYGSLDSAFCQIENVPRLDHFFNLFFQRALQPAKLHSSASPSAQQYDASSAVLLDNLPGVRWLTLPLEIKMELDMALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAVYCRHYCLLPLAAKQRIGQLIIWREVFPQHHLRPLADSSTEVFPEPEGRYFLLVVGLKHYMLCVLLEAGGCASKAIGSPGPDCVYVDQVKTTLHQLDGVDSRIDERLASSPVPCLSCADWFLTGSREKTDSLTTSPILSRLQGTSKVATSPTCRRTLFGDYSLKTRKPSPSCSSGGSDNGCEGGEDDGFSPHTTPDAVRKQRESQGSDGLEESGTLLKVTKKKSTLPNPFHLGNLKKDLPEKELEIYNTVKLTSGPENTLFHYVALETVQGIFITPTLEEVAQLSGSIHPQLIKNFHQCCLSIRAVFQQTLVEEKKKGLNSGDHSDSAKSVSSLNPVKEHGVLFECSPGNWTDQKKAPPVMAYWVVGRLFLHPKPQELYVCFHDSVTEIAIEIAFKLFFGLTL

Intu

Protein inturned

942 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (PubMed:20067783, PubMed:21761479). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Belongs to the inturned family.

104.821 kDa

MAGLARGDSRGRPPELPGDLSSQEEEEEEGDSDAGASSLGSYSSASSDTDVEPEWLDSVQKNGELFYLELSEDEEESLLPETQTANHVNHVRFSDKEVIIEEDDSRERKKSEPKLRRFTKILKSKSLLPRRHHKKSSSNNGPVSILKHQSSQKTGVTVQQRYKDVTVYINPRKLTAIKAREQVKLLEVLVGIIHQTKRSWKRSAKQADGERLVVHGLLPGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKRETAQPQKKKAQSSTQDLVKLLCGSEADAVQHSTLSIPHISMYLTLQLQSEAAREEQEILYHYPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHLNGKQIHVAYLKESDKLLLIGLPAEEVPLPQLRNMIEDVAQTLKFMYGSLDSAFCQVENAPRLDHFFSLFFERALRPGKLHLSGSPSAQQYAAASAVLLDNLPGVRWLVLPQELKVELDTALSDLEAADFEELSEDYYDMRRLYTILGSSLFYKGYMVCSHLPKDDVIEIAAYCRQHCLLPLAAKQRIGQLIIWREVFPRHHLQPPSDSDPEAFQEPEGRYFLLVVGLRHYLLCVLLEAGGCASKATGNPGPDCIYVDQVRATLHQLEGVDSRIEEQLATSPGPCLSCADWFLAAPREKADSLTTSPILSRLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPTEGEESAGLSPHATPDAVRKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYDIMKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHQCCLSIRAFFQQTLKEEKKKALSDGEHSEPTNSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQELYVCFHDSVSEIAIEMAFKLFFGLTL

Intu

Protein inturned

942 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Belongs to the inturned family.

105.142 kDa

MADPARRDPRGRAPELPGDLSSQEEEEEESDSDAGASSLGSCSSASSDTDLEPEWLDSVQRNGELFYLELSEDEEESLLPETQTVNHVNHVRFSEKEVIIEEDDSRERKKYEPKLRRFTKILKSKSLLPKRHHKKKSSNTGPVSILKHQSTQRTGVTVQQRYKDVTVYINPKKLTAIKAREQAKLLEVLVGVIHQTKWSWKRSGKQADGERLVVHGLVPGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKKETAQPKKKKAQSSTNDLVKLLCGSEADATQHSTLSIPHITMYLTLQLQSEVAREEQEMLYHYPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHVNGKQIHVAYLKESDKLLLIGLPAEEVPLPQLRNMTEDVAQTLKFMYGSLDSAFCQVENTPRLDHFFSLFFERALRPGKLHLSASPSAQQYDAASAVLLDNLPGVRWLLLPQELKVELDTALSDLEAADFQELSEDYYDMRRLYTILGSSLFYKGYMVCSHLPKDDVVEIAAYCRQYCLLPLAAQQRIGQLIIWREVFPQHHLQPATDSDPEAFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASKATGNPGPDCIYVDQARATLHQLEGVESRIEEQLAATPGPCLSCADWFLAAPREKADSLTTSPILGRLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPGEGEENVGLSPHTTPDTVRKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYNMMKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHRCCLTIRAVFQQTLKVEKKKALSDGDHLESANSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQELYVCFHDSVSEIAIEMAFRLFFGLTL

INTU

Protein inturned

942 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779).

Belongs to the inturned family.

105.648 kDa

MASVASCDSRPSSDELPGDPSSQEEDEDYDFEDRVSDSGSYSSASSDYDDLEPEWLDSVQKNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEDDYKERKKYEPKLKQFTKILRRKRLLPKRCNKKNSNDNGPVSILKHQSNQKTGVIVQQRYKDVNVYVNPKKLTVIKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGDGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVDVTTENIERVLSCIPGPMQVKLTFENAYDVKRETSHPRQKKTQSNTSDLVKLLWGEEVEGIQQSGLNTPHIIMYLTLQLDSETSKEEQEILYHYPMSEASQKLKSVRGIFLTLCDMLENVTGTQVTSSSLLLNGKQIHVAYWKESDKLLLIGLPAEEVPLPRLRNMIENVIQTLKFMYGSLDSAFCQIENVPRLDHFFNLFFQRALQPAKLHSSASPSAQQYDASSAVLLDNLPGVRWLTLPLEIKMELDMALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAVYCRHYCLLPLAAKQRIGQLIIWREVFPQHHLRPLADSSTEVFPEPEGRYFLLVVGLKHYMLCVLLEAGGCASKAIGSPGPDCVYVDQVKTTLHQLDGVDSRIDERLASSPVPCLSCADWFLTGSREKTDSLTTSPILSRLQGTSKVATSPTCRRTLFGDYSLKTRKPSPSCSSGGSDNGCEGGEDDGFSPHTTPDAVRKQRESQGSDGLEESGTLLKVTKKKSTLPNPFHLGNLKKDLPEKELEIYNTVKLTSGPENTLFHYVALETVQGIFITPTLEEVAQLSGSIHPQLIKNFHQCCLSIRAVFQQTLVEEKKKGLNSGDHSDSAKSVSSLNPVKEHGVLFECSPGNWTDQKKAPPVMAYWVVGRLFLHPKPQELYVCFHDSVTEIAIEIAFKLFFGLTL

Intu

Protein inturned

942 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (PubMed:20067783, PubMed:21761479). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Belongs to the inturned family.

104.821 kDa

MAGLARGDSRGRPPELPGDLSSQEEEEEEGDSDAGASSLGSYSSASSDTDVEPEWLDSVQKNGELFYLELSEDEEESLLPETQTANHVNHVRFSDKEVIIEEDDSRERKKSEPKLRRFTKILKSKSLLPRRHHKKSSSNNGPVSILKHQSSQKTGVTVQQRYKDVTVYINPRKLTAIKAREQVKLLEVLVGIIHQTKRSWKRSAKQADGERLVVHGLLPGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKRETAQPQKKKAQSSTQDLVKLLCGSEADAVQHSTLSIPHISMYLTLQLQSEAAREEQEILYHYPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHLNGKQIHVAYLKESDKLLLIGLPAEEVPLPQLRNMIEDVAQTLKFMYGSLDSAFCQVENAPRLDHFFSLFFERALRPGKLHLSGSPSAQQYAAASAVLLDNLPGVRWLVLPQELKVELDTALSDLEAADFEELSEDYYDMRRLYTILGSSLFYKGYMVCSHLPKDDVIEIAAYCRQHCLLPLAAKQRIGQLIIWREVFPRHHLQPPSDSDPEAFQEPEGRYFLLVVGLRHYLLCVLLEAGGCASKATGNPGPDCIYVDQVRATLHQLEGVDSRIEEQLATSPGPCLSCADWFLAAPREKADSLTTSPILSRLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPTEGEESAGLSPHATPDAVRKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYDIMKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHQCCLSIRAFFQQTLKEEKKKALSDGEHSEPTNSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQELYVCFHDSVSEIAIEMAFKLFFGLTL

Intu

Protein inturned

942 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Belongs to the inturned family.

105.142 kDa

MADPARRDPRGRAPELPGDLSSQEEEEEESDSDAGASSLGSCSSASSDTDLEPEWLDSVQRNGELFYLELSEDEEESLLPETQTVNHVNHVRFSEKEVIIEEDDSRERKKYEPKLRRFTKILKSKSLLPKRHHKKKSSNTGPVSILKHQSTQRTGVTVQQRYKDVTVYINPKKLTAIKAREQAKLLEVLVGVIHQTKWSWKRSGKQADGERLVVHGLVPGGSAMKSGQVLVGDVLVAVNDVDVTSENIERVLSCIPGPMQVKLTFENAYAVKKETAQPKKKKAQSSTNDLVKLLCGSEADATQHSTLSIPHITMYLTLQLQSEVAREEQEMLYHYPVSEASQKLKSVRGIFLTLCDMLESVTGTQVTSSSLHVNGKQIHVAYLKESDKLLLIGLPAEEVPLPQLRNMTEDVAQTLKFMYGSLDSAFCQVENTPRLDHFFSLFFERALRPGKLHLSASPSAQQYDAASAVLLDNLPGVRWLLLPQELKVELDTALSDLEAADFQELSEDYYDMRRLYTILGSSLFYKGYMVCSHLPKDDVVEIAAYCRQYCLLPLAAQQRIGQLIIWREVFPQHHLQPATDSDPEAFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASKATGNPGPDCIYVDQARATLHQLEGVESRIEEQLAATPGPCLSCADWFLAAPREKADSLTTSPILGRLQGPSKTAASPTCRRTFFSDYSFKARKPSPSRIGGGREPGEGEENVGLSPHTTPDTVRKQRESEGSDDNVALLKLARKKSTLPNPFHLGTSKKELSEKELEVYNMMKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLGGSVHSQLIKNFHRCCLTIRAVFQQTLKVEKKKALSDGDHLESANSVSSLSPVKEHGVLFECSPENWTDQKKTPPVMSYWVVGRLFLNPKPQELYVCFHDSVSEIAIEMAFRLFFGLTL

INTU

Protein inturned

933 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Belongs to the inturned family.

104.454 kDa

MASLPLCGSVRSPEGLPGDPSSQEDRQDYDPEDPVSGSGSYSPTSTDSNDLEPEWLDSVQKNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEEDDYREGKKYEPKLKRFTKILKSKKLLPKRYNKKNSNASGPVSILKHQSNQKMGVIVQQRHKDVNIYVNPKKLTVTKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGGGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVEVTSENIERVLSCIPGPMQVKLTFENAYAMKKETTQPRQKKAQLNTSDLVKLLWGEEVEGIQQNILNTPHIVMYLTLQLDSETSKEEQEILYHYPVSEASQKLQSVRGIFLTLCDMLENVTGTQVTSSSLLLNRKQIHIAYWKETDKLLLIGLPAEEVPLPQLRNMIEDVAQTLKFMYGSLDSAFCQVENVPRLDHFFSLFFQRALQPTKLHSSASPSTQQYDASSAVLLDNLPGVRWLTLPQEIKLELDTALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAVYCRHYCLLPLAAKQRIGQLVIWREVFPRHHLQPSADSNTEVFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASRAIGNPGPDCIYVDQVKTTLHQLEGVDSRINERLASSPTPCLSCADWFLAGSHEKLDNLTTSPILSRLHGASRVATSPTCRRTLFSDYSLKTRKPSPSRSGGPDSGLEGEGVGLSPHTTESQGSHGSEETGALLKVTKKKSALPNPFHLGNLKKDLSEKELDIYNTVKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLSGSIHPQLIKNFHQCCLSIRAVFQQTVAKEKKKALNGKDHSGSTNSVSSLNPVKEHGVLFECSPENWTDQRKAPPVMAYWVVGRLFLHPKLQELYVCFHDSVTEIAIEMAFKLFFGLTL

INTU

Protein inturned

933 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity). Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (By similarity).

Belongs to the inturned family.

104.454 kDa

MASLPLCGSVRSPEGLPGDPSSQEDRQDYDPEDPVSGSGSYSPTSTDSNDLEPEWLDSVQKNGELFYLELSEDEEESLLPETPTVNHVRFSENEIIIEEDDYREGKKYEPKLKRFTKILKSKKLLPKRYNKKNSNASGPVSILKHQSNQKMGVIVQQRHKDVNIYVNPKKLTVTKAKEQLKLLEVLVGIIHQTKWSWRRTGKQGGGERLVVHGLLPGGSAMKSGQVLIGDVLVAVNDVEVTSENIERVLSCIPGPMQVKLTFENAYAMKKETTQPRQKKAQLNTSDLVKLLWGEEVEGIQQNILNTPHIVMYLTLQLDSETSKEEQEILYHYPVSEASQKLQSVRGIFLTLCDMLENVTGTQVTSSSLLLNRKQIHIAYWKETDKLLLIGLPAEEVPLPQLRNMIEDVAQTLKFMYGSLDSAFCQVENVPRLDHFFSLFFQRALQPTKLHSSASPSTQQYDASSAVLLDNLPGVRWLTLPQEIKLELDTALSDLEAADFAELSEDYYDMRRLYTILGSSLFYKGYLICSHLPKDDLIDIAVYCRHYCLLPLAAKQRIGQLVIWREVFPRHHLQPSADSNTEVFQEPEGRYFLLIVGLRHYMLCVLLEAGGCASRAIGNPGPDCIYVDQVKTTLHQLEGVDSRINERLASSPTPCLSCADWFLAGSHEKLDNLTTSPILSRLHGASRVATSPTCRRTLFSDYSLKTRKPSPSRSGGPDSGLEGEGVGLSPHTTESQGSHGSEETGALLKVTKKKSALPNPFHLGNLKKDLSEKELDIYNTVKLTSGPENTLFHYVALETVQGIFITPTHEEVAQLSGSIHPQLIKNFHQCCLSIRAVFQQTVAKEKKKALNGKDHSGSTNSVSSLNPVKEHGVLFECSPENWTDQRKAPPVMAYWVVGRLFLHPKLQELYVCFHDSVTEIAIEMAFKLFFGLTL

intu

Protein inturned

915 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity).

Belongs to the inturned family.

101.132 kDa

MFSTCSDGRPFQSFSTNLEDFDSIRSVLLYSDLEPEWLDDVQKNGQLFYLELSDGEEEALLAQVSANHSAATNHVRFSEKEAEIITDNAKRQANSSNKSEAKLKKLTKILRRKRRPSQRKAEGKDSSQRPASILKNQAGQRPGVVVQQQRLKDVCVYLNPKRLSSVSSSSADRGGLLEALLGVVHRPGGNTGKRGGKLIIHGLIPHSPASKCAEILIGDALVAVDDVEVTSENIERVLSCIPGPMQVRLTLETVCPAGVSPESKVSASPQVSQLVRLLWGEDTIELQMSIADVPHIAMFLSLRLDSETQQDEQEIVYQYPQSEASAQLKAVRGIFLTLCDMLENVTGGQIISSSLWLQQQLVHVGYWKEESNLLVIAVPASRVPLLYLQTVIEGVVRTLKVMYGSLDRGFSDVENAPRLDHFFCLFFQQLIQPSRLIHSSRTPDLYGSLFLDGLPAVRWLTLPPDIKVEVDTVLSDFESSDFGDMSEDFYGMRRLYVILGSCLFYKGYLIANHLPKEDLLDVCLYCQHYCLLPLASEQRVAQLVVWREVFPQRRETRNSTAHPGYCQPHARHFLLIVGLRHFMQCVLLEAGGCASSAVGRPTPDSVYVDQVKATLLQLESLDAGIEERLSAPPTPCLSCADWFLPAGGRSQQDTIGSSPILNRLTAAIKPPSPGGIGRSLFGEAGTVGIRGRRASPQRSQSDSGSEGHADGTPASVARRDSLGSGGSDGSLGSAGFLKMPRLKHPNPFYLGSLRKSLSERETEEMQNVLQVTAGVENTLFHYVLMESVQGIFIAPTHTEIRHLSGSIHPQLIHNFQHCCLSIRQAFQQSLPTRDRRGPERQSTAGLGPVKEHGVLFQCKPQNWTDQKKPAPTMTYWVIGRMLLEPVPQEFYVCFHDSVAEVPVEMAFRLSFGLAV

intu

Protein inturned

915 amino acids

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity).

Belongs to the inturned family.

101.132 kDa

MFSTCSDGRPFQSFSTNLEDFDSIRSVLLYSDLEPEWLDDVQKNGQLFYLELSDGEEEALLAQVSANHSAATNHVRFSEKEAEIITDNAKRQANSSNKSEAKLKKLTKILRRKRRPSQRKAEGKDSSQRPASILKNQAGQRPGVVVQQQRLKDVCVYLNPKRLSSVSSSSADRGGLLEALLGVVHRPGGNTGKRGGKLIIHGLIPHSPASKCAEILIGDALVAVDDVEVTSENIERVLSCIPGPMQVRLTLETVCPAGVSPESKVSASPQVSQLVRLLWGEDTIELQMSIADVPHIAMFLSLRLDSETQQDEQEIVYQYPQSEASAQLKAVRGIFLTLCDMLENVTGGQIISSSLWLQQQLVHVGYWKEESNLLVIAVPASRVPLLYLQTVIEGVVRTLKVMYGSLDRGFSDVENAPRLDHFFCLFFQQLIQPSRLIHSSRTPDLYGSLFLDGLPAVRWLTLPPDIKVEVDTVLSDFESSDFGDMSEDFYGMRRLYVILGSCLFYKGYLIANHLPKEDLLDVCLYCQHYCLLPLASEQRVAQLVVWREVFPQRRETRNSTAHPGYCQPHARHFLLIVGLRHFMQCVLLEAGGCASSAVGRPTPDSVYVDQVKATLLQLESLDAGIEERLSAPPTPCLSCADWFLPAGGRSQQDTIGSSPILNRLTAAIKPPSPGGIGRSLFGEAGTVGIRGRRASPQRSQSDSGSEGHADGTPASVARRDSLGSGGSDGSLGSAGFLKMPRLKHPNPFYLGSLRKSLSERETEEMQNVLQVTAGVENTLFHYVLMESVQGIFIAPTHTEIRHLSGSIHPQLIHNFQHCCLSIRQAFQQSLPTRDRRGPERQSTAGLGPVKEHGVLFQCKPQNWTDQKKPAPTMTYWVIGRMLLEPVPQEFYVCFHDSVAEVPVEMAFRLSFGLAV