Protein
Insulin receptor-related protein
Function
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB (By similarity).
Similarity
Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Sequence
MARPKLWPWGILLLVSLLSAGFNLDTMNVCPSLDIRSEVAELRRLENCSVVEGHLQILLMFTATGEDFRSLSFPHLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGAHLFLGYALVIFEMPHLRDVGLPALGAVLHGSVRVEKNQELCHLSTIDWGLLQPTPSTNYIVGNKLGEECADVCPGTLGAAGEPCARTTFNGHTDYRCWTSSHCQRVCPCPQGLACTISGECCHTECLGGCSQPEDPRACVACRHFYYQSACHRACPLGTYEHESWRCVTAESCANLRSVPGRASTFGIHQGKCLAQCPPGFTRNGSSIFCHKCEGLCPKECKVGTKTIDSVQAAQDLVGCTHVEGSLILNLRRGYNLEPELQRSLGLVETITGFLKIKHSFALVSLSFFKNLKLIRGDTMVDGNYTLYVLDNQNLQQLGPWVSAGLTIPVGKIYFAFNPRLCLEHIYRLEEVTGTRGRQNKAEINPRTNGDRAACQTRTLRFVSNVTEADRILLRWERYEPLEARDLLSFIVYYKESPFQNATEHVGPDACGSQSWNLLDVELPLSRTQEPGVILAPLKPWTQYAVFVRAITLTTAEDSPHQGAQSPIVYLWTLPAAPTVPQDVISSSNSSSHLLVRWKPPTQRNGNITYYLVLWQRLAEDGDLYLNDYCHRGLRLPTSNHDPRFDREDGDLEAELELGCCPCQHAPPGQVLPALEAQEASFQKKFENFLHNAITIPKPPWKVTSIHRNLQRDAGRHRRAIGSPRPGGNSSDFEIQEDKVPRERAVLGGLRHFTEYRIDIHACNHAAHIVGCSAATFVFARTMPRREADDIPGKLSWEAASKSSVLLRWFEPPDPNGLILKYEIKYRRLGEEATVLCVSRLRYAKVGGVQLALLPPGNYSARVRATSLAGNGSWTDSVAFYIPGPEEEDSGGLHILLTVTPAGLMLLIILAALGFFYSRKRNGTLYTSVNPEYLSASDMYIPDEWEVPREQISIIRELGQGSFGMVYEGVAKGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFQCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGIPRPALGDMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEDCPHQLQELMSSCWQQNPRLRPTFTQILNSIQKELRPSFRLLSFYHSPECQGGCGLQPTTDAESSSPPTSKGASDCSLQNGGPEH