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INSM1

Gene
INSM1
Protein
Insulinoma-associated protein 1
Organism
Bos taurus
Length
522 amino acids
Function
Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4'. Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.
Similarity
Belongs to the INSM1 family.
Mass
53.935 kDa
Sequence
MPRGFLVKRSKKSTPVSYRIRGGEDGDRALLLLPGCGGARASPPAPGPGPVPGPLQPPPPTERAHAALAAALACAPGPPPPPPGLRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLVGGGGGGGGGGANGAGGGGTCSGDPLLFAPAELKMGTAFSAAAEAARGPGPGPPLPPAAALRPPGKRPSPPASAAAAAEPPAKVAKAPGSKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARACEPETPARAEAREATGGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPPPAPPAEDLLALYPGPDEKVPQEAAGDGEAAGVLGLSASAECHLCPVCGETFPSKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC

Gene
Insm1
Protein
Insulinoma-associated protein 1
Organism
Mus musculus
Length
521 amino acids
Function
Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (By similarity). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.
Similarity
Belongs to the INSM1 family.
Mass
54.05 kDa
Sequence
MPRGFLVKRSKKSTPVSYRVRGGEDSDRALLLSPGCGGARAEPPVPSPGPLPPPPPPALAERAHAALAAALACAPGPPPPPPPGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLAGGGSGANGAGGGGGGTCGGDALLFAPAELKMGTAFSAGAEAARGPGTGPPLSPAAALRPPGKRPAPPAAVATEPPAKAAKAPSAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGATRPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPVPAAARAPEPEAATRAEAREAAGGGSSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPPPPPPPPPPAEDILAFYAGPDEKAPQEASGDGEAAGVLGLSATAQCHLCPVCGETFPSKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC

Gene
INSM1
Protein
Insulinoma-associated protein 1
Organism
Homo sapiens
Length
510 amino acids
Function
Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (PubMed:23721412). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation.
Similarity
Belongs to the INSM1 family.
Mass
52.923 kDa
Sequence
MPRGFLVKRSKKSTPVSYRVRGGEDGDRALLLSPSCGGARAEPPAPSPVPGPLPPPPPAERAHAALAAALACAPGPQPPPQGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLGGGGGGGASGAGGGGTCGGDPLLFAPAELKMGTAFSAGAEAARGPGPGPPLPPAAALRPPGKRPPPPTAAEPPAKAVKAPGAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGAARPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPAPAAARAPEPEAAARAEAREAPGGGSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPLAPPAEDLLALYPGPDEKAPQEAAGDGEGAGVLGLSASAECHLCPVCGESFASKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC

Gene
insm1
Protein
Insulinoma-associated protein 1
Organism
Xenopus tropicalis
Length
441 amino acids
Function
May act as a transcriptional regulator. Plays a role in noradrenergic neuron, pancreatic and gastrointestinal endocrine cells differentiation during embryonic development (By similarity).
Similarity
Belongs to the INSM1 family.
Mass
47.965 kDa
Sequence
MPKGFLVKRSRKSPPVSYRVREEEEPRGESLPGWMLLATMCPTGGAPPPCSPDRATQAPCCSSPRPPPAGQFGNPDTVQQALYSPTRPVSREQRERKYLGSPVSAESFPGLGTSSEALLYPPTGTANGHHGLALLPPVSSSSSVSRSQGKRPAPEPDSKPAAMPGTGPGATSSSAPSKPPAAKKTKAIRKLTFEDEVTTSPVLGLKIKEGPVEPPRPRAASSGPRPLGEFICQLCKEEYSDPFSLAQHKCSRIVRVEYRCPECHKVFSCPANLASHRRWHKPRPPVASTAQAKEEPLSDRDTPSPGASESGSEDGLYECPRCARKFRRQAYLRKHLLSHQAAKEPEEPGVMMFPGEEQRAKSPPSLNAQECHPCPVCGETFPGKSSQERHIRLLHSSQLYPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC

Gene
insm1
Protein
Insulinoma-associated protein 1
Organism
Xenopus laevis
Length
433 amino acids
Function
May act as a transcriptional regulator (By similarity). Plays a role in noradrenergic neuron, pancreatic and gastrointestinal endocrine cells differentiation during embryonic development.
Similarity
Belongs to the INSM1 family.
Mass
47.581 kDa
Sequence
MPKGFLVKRNRKSPPVSYRVREDEENRGESLPGWMLLATMCPTGGAPPPSSPERLASAAPSCNNPRPPPAGQFGNPEAVPQTLYSPTRPVSREQRERKYLGSPVSAESFPGLGSSSEALLFPPTSTANGHHGLALLPPVSSSSSISRTHGKRPAPEPDVKAGAAPGTACKPPAAKKTKAIRKLTFEDEVTTSPVLGLKIKEGPVEPPRPRAPSSGPRPLGEFICQLCKEEYSDPFSLAQHKCSRIVRVEYRCPECHKVFSCPANLASHRRWHKPRPPAVPAVQPKEEALSDRDTPSPESGSEDGLYECPRCARKFRRQAYLRKHLLSHQVTKEPEEAGHMMYQSDEQRPQAKSPPSLNVPQECHPCPVCGETFPGKSSQERHIRLLHSSQLYPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC