About Products Protein Database Contact

INSIG2

Gene
INSIG2
Protein
Insulin-induced gene 2 protein
Organism
Pongo abelii
Length
238 amino acids
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).
Similarity
Belongs to the INSIG family.
Mass
26.444 kDa
Sequence
MAEGETKSPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAENLIRNEEGKKYLLYRKTR

Gene
INSIG2
Protein
Insulin-induced gene 2 protein
Organism
Callithrix jacchus
Length
225 amino acids
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).
Similarity
Belongs to the INSIG family.
Mass
24.891 kDa
Sequence
MVEEETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFNREWSNVMRCVAVFVGINHASAKLDFDNNIQLSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE

Gene
INSIG2
Protein
Insulin-induced gene 2 protein
Organism
Homo sapiens
Length
225 amino acids
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
Similarity
Belongs to the INSIG family.
Mass
24.778 kDa
Sequence
MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE

Gene
Insig2
Protein
Insulin-induced gene 2 protein
Organism
Mus musculus
Length
225 amino acids
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
Similarity
Belongs to the INSIG family.
Mass
24.915 kDa
Sequence
MAEGETESPRPKKCGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVITSIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE

Gene
INSIG2
Protein
Insulin-induced gene 2 protein
Organism
Papio anubis
Length
225 amino acids
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).
Similarity
Belongs to the INSIG family.
Mass
24.792 kDa
Sequence
MAEGETESPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATLVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE

Gene
INSIG2
Protein
Insulin-induced gene 2 protein
Organism
Sus scrofa
Length
225 amino acids
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).
Similarity
Belongs to the INSIG family.
Mass
24.791 kDa
Sequence
MAEGETKSPGPKKCGPYISSVTSQSVNLMIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVIASIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATLVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE

Gene
Insig2
Protein
Insulin-induced gene 2 protein
Organism
Rattus norvegicus
Length
225 amino acids
Function
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity).
Similarity
Belongs to the INSIG family.
Mass
24.968 kDa
Sequence
MAEGETESPRPKKRGPYISSVTSQSVNVVIRGVVLFFIGVFLALVLNLLQIQRNVTLFPPDVITSIFSSAWWVPPCCGTASAVIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFDNNFQFSLTLAALSVGLWWTFDRSRSGFGLGVGIAFLATVVTQLLVYNGVYQYTSPDFLYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHQE

Gene
insig2
Protein
Insulin-induced gene 2 protein
Organism
Xenopus laevis
Length
218 amino acids
Function
Mediates feedback control of cholesterol synthesis.
Similarity
Belongs to the INSIG family.
Mass
24.359 kDa
Sequence
MGDRENVSYGSRPILAQKMNLLLRGFLLFLIGVFLALVLNLLQVQRNVTLFPPDVLSSLFSSAWWVPLCCGTAAAAIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFANNMQLSLTLAALSIGLWWTFDRSRSGLGLGIGISFFATLVSQLLVYNGVYEYTAPDFLYVRSWLPCIFFAGGITMGNIGRQLEMYERKALVEKSHRD

Gene
insig2
Protein
Insulin-induced gene 2 protein
Organism
Xenopus tropicalis
Length
218 amino acids
Function
Mediates feedback control of cholesterol synthesis.
Similarity
Belongs to the INSIG family.
Mass
24.195 kDa
Sequence
MGETDNAPRGPPSFLPHKMNLLLRGLLLFLIGVFLALVLNLLQVQRNVTLFPPDVLSSLFSSAWWVPLCCGTAAAAIGLLYPCIDRHLGEPHKFKREWSSVMRCVAVFVGINHASAKVDFANNTQLSLTLAALSIGLWWTFDRSRSGLGLGIGISFFATVVSQLLVYNGVYEYTAPDFLYVRSWLPCIFFAGGITMGNIGRQLEMYERLALVEKSHRD

Gene
INSIG2
Protein
Insulin-induced gene 2 protein
Organism
Gallus gallus
Length
167 amino acids
Function
Mediates feedback control of cholesterol synthesis.
Similarity
Belongs to the INSIG family.
Mass
18.161 kDa
Sequence
MAENDAKPTLPKKSGPYISSVTSRGMNLVIRGIVLFFIGVFLALVLNLLNAVCSGLCQGINHASAKVDFANNIQLSLTLAALSIGLWWTFDRSRSGFGLGVGIAFLATLVSQLLVYNGVYQYTSPDFIYVRSWLPCIFFAGGITMGNIGRQLAMYECKVIAEKSHED