INCENP

Inner centromere protein

918 amino acids

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules (PubMed:15316025, PubMed:12925766, PubMed:27332895). The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC (PubMed:27332895). Required for localization of CBX5 to mitotic centromeres (PubMed:21346195). Controls the kinetochore localization of BUB1 (PubMed:16760428).

Belongs to the INCENP family.

105.429 kDa

MGTTAPGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSRRKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAAAAAAATMALAAPSSPTPESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPRDSPAFPDSPWRERVLAPILPDNFSTPTGSRTDSQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQKEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYYHPPNLLELFGTILPLDLEDIFKKSKPRYHKRTSSAVWNSPPLQGARVPSSLAYSLKKH

incenp

Inner centromere protein

898 amino acids

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with aurkb/aurora-B, the N-terminus associated with cdca8/borealin and/or cdca9/dasra-A tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs aurkb/aurora-B toward substrates near microtubules. Activates aurkb.

Belongs to the INCENP family.

104.13 kDa

MNDAECLSHLLQVCARKTEEFVRTLDSKHMVWLLEIEEEARKMFSSDFNAEPELMPKTPSQKRRRKKRTSIVPDENRDPSGRRISRRRSSANWSNSVRRLSIRNQNKTNEDSMQEEPAQPKRMTRARAQASIMCPSVVEMALPESPSQLYQKNVQVTISEQDRRSAEQKLVGSATEESEMKTDVLPVPKIAKDTISEIVNTVVPPPVPETPAVPVTPENKSRAAAKLKIAGSSTPIEAAEMVDLTCESPRPANELANEQPLNLTNQSVTPTGSKSDRRSVRRSLVVVKPSSRRSSLASQFSLASKRESMTREAVRKSIRQSIAKKKAAMETSSASSQRSCQSSIEIIDDEITIKIRPETAPSESVSEEAHTIESPRRSLRSRTFKKIAISNLPDSEEPQRRVTRQMVAMDAEPTPETTDDAQNIRRKSYKRAVDELSDDERPSEGERSPPRKKTPSPPCPPSKIVKPPPHMKSFLHTVQKNQLLMMTPGSIGKNIMMKSFIKRNTPLKMDPKEKERQRLDALRKKEEAELQRKQKIEEGKKRKQEELKLRREERLRKVLQARERVEQLEEEKKKKIEQKFAQIDEKSEKVREDRMAEEKAKKKITAKKQEEVECRRRQEEEARKLKAKQMEEEERRHQDLLQKKREEEELERQKKIAEAKRLAEQRQAEQERERQREQQLLAEKERLRAERERIEREKALQLQRELERAAQEKEQQRREAEERKKREQQERLEQERLERLHKEQEAKRLQEEQQRKAKEQAAAASAPVMNVTVDMQNSPACESYEMTPKSYKAPSVKVNEENYGMDLNSDDSTDDESQPRKPIPAWASGNLLAQAIRQQYYKPMDVDRMYGTIDSPKLEELFYKSKPRYYKRTSSAVWHSPPLSSNRHHLAVGYGLKY

Incenp

Inner centromere protein

880 amino acids

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC. Controls the kinetochore localization of BUB1.

Belongs to the INCENP family.

101.209 kDa

MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERMFIREFSNEPELMPKTPSQKNRRKKRRVSNIQDENRDPVRKRLSRRKSRSSQVGTRHLRSKPVTIVEENGFPVLQRITRATAAAAAAAAAASVASASSSSTAGSPTVLTKKAVVEISTSERLSAELQLTKLKGSLPPSPVSQGTLTSEEELTPKKSEAGKLDSVTVNSLKATPQSPKNRGVGEGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLGNIRSVRRSLISQDSQVPLASKYNLVAKQENGSRRSSRRIAKKAGKEPEASARIICHSYLERLLNVEVPQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSKPAAAGQTTTVEEQEAELDQTDGHREPPQSVRRKRSYKQAISEPDEEQLEDEELQPCQNKTPSPPCPANKVVRPLRTFLHTVQKNQMLMTPTLASRSSVMKSFIKRNTPLRVDPKCSFVEKERQRLESLRRKEEAEQRRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEKAKKKATAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQEMLQRKKEEEQERRKAAEARRLAEQREQERRREQERREQERREQERREQERKEQERREQEQERLRAKREMQEREKALRLQKERLQKELEEKKRKEEQQRLAEQQLQEEQAKKAKEVAAARKVLNMTVDVQSPVCTSYQMTPQGPKSIPKISVDDYGMDLNSDDSTDDESHPRKPIPSWAKGTQLSQAIVHQYYHPPNILELFGSILPLDLEDIFKKRKTRYHKRTSSAVWNSPPLKATMVPSSGD

INCENP

Inner centromere protein

877 amino acids

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB.

Belongs to the INCENP family.

100.941 kDa

MAVATGLARLPVVCNQRLAELLRQVDDVDLLWLEEIHEEAARMFGSHYSDQPELMPKTPSQKNRKRRKRPSALRGESLELGRRRLSRRRTNNLKAVSSKRDSQRLQNKEDTEGLGTEAQELSSQTVSRRLTRSQVAAPADRSEVLPEHLRERVVPVVEISVCDRISAEFQFQKCASERAENHSASLPPSSDDKSPKESSAAESQPLPAASELIVPHTPEAKGAGKNKSAFKKTANVADTTVVLSEKELGLEEVDDSAQVQKHNERDDKEPSQRTTDSPETPTGSRLSRRSVRRSLMGKPSTIRRTSLAEKYSLARKRESTIRKSIARTVIKRKAPQKLSVSSSSVNGSGSEEVPEDEETVVNAGPPPVPQTPPKLDFQGLRMSLRSQTVNRNEQQQETSNNECDLSKSEKTQEPPQSARRKTSYKRAVDQRYDTQQAEDGGLSPLRKKTPSPPCPASKVVRPFKTFLHTVEKNQLLMTPSSVGRNGVIKSFIKYNTPLQHDPKEKERQKLQALRKKEEAEQLRKQKVEEEKKRRQEEAKLRREERLRKVLQARERAEQLEEERKRRIEQKLALFDEKTEKAREERLAEEKIKKRAAAKKMEEAEARRRQDEEARKQKALQQEEEERRHKELMQKKKEEEQERARKIAEQRQAEQEREKQLAAEREQERKKEQERKKEEERIQAEKQREQQEKAARLQKEVLAAKEQLQKEMEKKEKEEQLLAEMKRQEQEQKKLPEEQKAKDVAQTQHLENKENSPACNSYQMTPQYHKDPKPPKINPNNYGMDLNSDDSTDDESQPRKPIPAWASGNQLSQAVIRQYYNPPNVDALFGTIVSPKLEDIFYKSKPRYFKRTSSAVWNSPPFPGAKSVLGLPYSLKKY