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IL21

Gene
IL21
Protein
Interleukin-21
Organism
Homo sapiens
Length
162 amino acids
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Similarity
Belongs to the IL-15/IL-21 family.
Mass
18.653 kDa
Sequence
MRSSPGNMERIVICLMVIFLGTLVHKSSSQGQDRHMIRMRQLIDIVDQLKNYVNDLVPEFLPAPEDVETNCEWSAFSCFQKAQLKSANTGNNERIINVSIKKLKRKPPSTNAGRRQKHRLTCPSCDSYEKKPPKEFLERFKSLLQKMIHQHLSSRTHGSEDS

Gene
IL21
Protein
Interleukin-21
Organism
Bos taurus
Length
152 amino acids
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
Similarity
Belongs to the IL-15/IL-21 family.
Mass
17.69 kDa
Sequence
MRWPGNMERIVICLMVIFSGTVAHKSSSQGQDRLFIRLRQLIDIVDQLKNYVNDLDPEFLPAPEDVKRHCERSAFSCFQKVQLKSANNGDNEKIINILTKQLKRKLPATNTGRRQKHEVTCPSCDSYEKKPPKEYLERLKSLIQKMIHQHLS

Gene
IL21
Protein
Interleukin-21
Organism
Sus scrofa
Length
152 amino acids
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Similarity
Belongs to the IL-15/IL-21 family.
Mass
17.575 kDa
Sequence
MRWPGNMEKIVICLMVIFSGTVAHKSSFQGQDRLLIRLRQLIDTVDQLKNYVHDLDPELLPAPEDVQRHCEQSAFSCFQKVELKSANTGDNEKIINVLIKQLKRKLPPTNAGRRQKHGLTCPTCDSYEKKPIKEFLERLKSLIQKMIHQHLS

Gene
IL21
Protein
Interleukin-21
Organism
Canis lupus familiaris
Length
146 amino acids
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
Similarity
Belongs to the IL-15/IL-21 family.
Mass
16.776 kDa
Sequence
MEKIVICLMVIFLGTVAHKSSFQEQDLLLIRMRQLIDIVDQLKNYVNDLDPESLPAPEDVKRHCERSAFSCFQKVQLKAANTGGNEQIINVLTKQLKRKLPPTNAGRRQKHRPACPSCDSYEKAPPKEFLERLKSLIQKMIHQHLS

Gene
Il21
Protein
Interleukin-21
Organism
Mus musculus
Length
146 amino acids
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Similarity
Belongs to the IL-15/IL-21 family.
Mass
16.811 kDa
Sequence
MERTLVCLVVIFLGTVAHKSSPQGPDRLLIRLRHLIDIVEQLKIYENDLDPELLSAPQDVKGHCEHAAFACFQKAKLKPSNPGNNKTFIIDLVAQLRRRLPARRGGKKQKHIAKCPSCDSYEKRTPKEFLERLKWLLQKMIHQHLS

Gene
Il21
Protein
Interleukin-21
Organism
Rattus norvegicus
Length
146 amino acids
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
Similarity
Belongs to the IL-15/IL-21 family.
Mass
17.065 kDa
Sequence
MERTLVCLILIFLGTVAHKSSPQRPDHLLIRLRHLMDIVEQLKIYENDLDPELLTAPQDVKGQCEHEAFACFQKAKLKPSNTGNNKTFINDLLAQLRRRLPAKRTGNKQRHMAKCPSCDLYEKKTPKEFLERLKWLLQKMIHQHLS

Gene
Il21
Protein
Interleukin-21
Organism
Peromyscus maniculatus
Length
123 amino acids
Function
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (By similarity).
Similarity
Belongs to the IL-15/IL-21 family.
Mass
13.945 kDa
Fragment
single
Sequence
VVIFLGTVAHKTSPQRPDRLLIRLRHLVDNVEQLKIYVNDLDPELLPAPQDVKEHCAHSAFACFQKAKLKPANTGSNKTIISDLVTQLRRRLPATKAEKKQQSLVKCPSCDSYEKKTPKEFLE