IGHMBP2

DNA-binding protein SMUBP-2

993 amino acids

5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region. May be involved in translation (By similarity). DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr. Stimulates the transcription of the human neurotropic virus JCV.

Belongs to the DNA2/NAM7 helicase family.

109.149 kDa

MASAAVESFVTKQLDLLELERDAEVEERRSWQENISLKELQSRGVCLLKLQVSSQRTGLYGRLLVTFEPRRYGSAAALPSNSFTSGDIVGLYDAANEGSQLATGILTRVTQKSVTVAFDESHDFQLSLDRENSYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPASEIHPLTFFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKQRILRLGHPARLLESIQQHSLDAVLARSDSAQIVADIRKDIDQVFVKNKKTQDKREKSNFRNEIKLLRKELKEREEAAMLESLTSANVVLATNTGASADGPLKLLPESYFDVVVIDECAQALEASCWIPLLKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAEEYGARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLRDLPGVAATEETGVPLLLVDTAGCGLFELEEEDEQSKGNPGEVRLVSLHIQALVDAGVPARDIAVVSPYNLQVDLLRQSLVHRHPELEIKSVDGFQGREKEAVILSFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAFEYLDDIVPENYSHENSQGSSHAATKPQGPATSTRTGSQRQEGGQEAAAPARQGRKKPAGKSLASEAPSQPSLNGGSPEGVESQDGVDHFRAMIVEFMASKKMQLEFPPSLNSHDRLRVHQIAEEHGLRHDSSGEGKRRFITVSKRAPRPRAALGPPAGTGGPAPLQPVPPTPAQTEQPPREQRGPDQPDLRTLHLERLQRVRSAQGQPASKEQQASGQQKLPEKKKKKAKGHPATDLPTEEDFEALVSAAVKADNTCGFAKCTAGVTTLGQFCQLCSRRYCLSHHLPEIHGCGERARAHARQRISREGVLYAGSGTKNGSLDPAKRAQLQRRLDKKLSELSNQRTSRRKERGT

Ighmbp2

DNA-binding protein SMUBP-2

993 amino acids

5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region (By similarity). May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr.

Belongs to the DNA2/NAM7 helicase family.

109.466 kDa

MASSTVESFVAQQLQLLELERDAEVEERRSWQEHSSLRELQSRGVCLLKLQVSSQRTGLYGQRLVTFEPRKFGPAVVLPSNSFTSGDIVGLYDTNENSQLATGVLTRITQKSVTVAFDESHDLQLNLDRENTYRLLKLANDVTYKRLKKALMTLKKYHSGPASSLIDILLGSSTPSPAMEIPPLSFYNTTLDLSQKEAVSFALAQKELAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKKRILRLGHPARLLESVQHHSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKGNFRSEIKLLRKELKEREEAAIVQSLTAADVVLATNTGASSDGPLKLLPEDYFDVVVVDECAQALEASCWIPLLKAPKCILAGDHRQLPPTTVSHRAALAGLSRSLMERLAEKHGAGVVRMLTVQYRMHQAIMCWASEAMYHGQFTSHPSVAGHLLKDLPGVTDTEETRVPLLLIDTAGCGLLELEEEDSQSKGNPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPELEIKSVDGFQGREKEAVLLTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLETLVDYFTEHGEVRTAFEYLDDIVPENYTHEGSQGHSRVPKPKCPSTSIRKPASDQESGQETRAAPRHGRRKPSEKPPGSHVQSQHSSSANGSDRTGGPDRTEHFRATIEEFVASKESQLEFPTSLSSHDRLRVHQLAEEFGLRHDSTGEGKARHITVSRRSPASSGSVAPQPSSPPSPAQAEPEPRAEEPVTVVQAHCPVQLDLKALHLERLQRQQSSQAQTAKGQPGGDSRPQKASQKKKKKEPKGPVMALPCEEDFDALVSAVVKADNTCSFSKCSVSTTTLGQFCMHCSHRYYLSHHLPEIHGCGEKARAHARQRISREGVLYAGSGTKDRALDPAKRAQLQRRLDKKLGELSSQRTSRKKEKERGT

IGHMBP2

DNA-binding protein SMUBP-2

989 amino acids

5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron (By similarity). May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr (By similarity). Binds to the insulin II gene RIPE3B enhancer region.

Belongs to the DNA2/NAM7 helicase family.

108.439 kDa

MALSTVESFVAQQLELLELERDAEVEERRSWQEHSSLKELQSRGVCLLKLQVSSQCTGLYGQRLVTFEPRKLGPVVVLPSNSFTSGDIVGLYDANESSQLATGVLTRITQKSVTVAFDESHDFQLNLDRENTYRLLKLANDVTYKRLKKALMTLKKYHSGPASSLIDVLLGGSSPSPTTEIPPFTFYNTALDPSQKEAVSFALAQKEVAIIHGPPGTGKTTTVVEIILQAVKQGLKILCCAPSNVAVDNLVERLALCKKRILRLGHPARLLESAQQHSLDAVLARSDNAQIVADIRKDIDQVFGKNKKTQDKREKSNFRNEIKLLRKELKEREEAAIVQSLTAADVVLATNTGASSDGPLKLLPENHFDVVVVDECAQALEASCWIPLLKAPKCILAGDHRQLPPTTISHKAALAGLSRSLMERLVEKHGAGAVRMLTVQYRMHQAITRWASEAMYHGQLTAHPSVAGHLLKDLPGVADTEETSVPLLLIDTAGCGLLELDEEDSQSKGNPGEVRLVTLHIQALVDAGVHAGDIAVIAPYNLQVDLLRQSLSNKHPELEIKSVDGFQGREKEAVILTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVDYFTEHGEVRTAFEYLDDIVPENYTHEGSQGHSHAPKPRGPVTSIRKPTNEQENGQEARAAAGQGRRKPNERPPGSQVHSQPSSGARGCDRTGAIDRTEHFRAMIEGFVASKESQLEFPASLSSHDRLLVHQIAEEHGLRHDSTGEGKARHITVSRKSPAGSGGVAPQLPSPPSPAQAEPEPLSQQPLGQPHCSTQLDLKALHLQRLQRQQGSQAQPAKAQPGVGLHPQKTQQKKKKKETKGPALPCEEDFDALVSAVIKADNTCSFAKCTASTTTLGQFCMHCSRRYCLSHHLPEIHGCGEKARAHARQMISREGVLYAGSGTRDRALDPAKRAQLQRRLDKKLGELSSQRTSKRKEKERGT

Ighmbp2

DNA-binding protein SMUBP-2

988 amino acids

5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region (By similarity). May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch region. Preferentially binds to the 5'-GGGCT-3' motif. Interacts with tRNA-Tyr (By similarity).

Belongs to the DNA2/NAM7 helicase family.

108.44 kDa

MASYTVESFVAQQLQLLELERDAEVEERRSWQEHSSLKELQSRGVCLLKLQVSGQRTGLYGQRLVTFEPRKFGPAVVLPSNSFTSGDIVGLYDTNESSQLATGVLTRITQKSVIVAFDESHDFQLNLDRENTYRLLKLANDVTYKRLKKALLTLKKYHSGPASSLIDVLLGGSTPSPATEIPPLTFYNTTLDPSQKEAVSFALAQKEVAIIHGPPGTGKTTTVVEIILQAVKQGLKVLCCAPSNIAVDNLVERLALCKKQILRLGHPARLLESVQQHSLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREKSNFRNEIKLLRKELKEREEAAIVQSLSAADVVLATNTGASTDGPLKLLPEDYFDVVVVDECAQALEASCWIPLLKAPKCILAGDHKQLPPTTVSHKAALAGLSRSLMERLAEKHGAAVVRMLAVQYRMHQAITRWASEAMYHGQLTAHPSVAGHLLKDLPGVADTEETSVPLLLIDTAGCGLLELEEEDSQSKGNPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSLSNKHPELEIKSVDGFQGREKEAVILTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSHTVNNHAFLKTLVDYFTEHGEVRTAFEYLDDIVPENYTHEGSRSHSCAPKPKCPTTSVRKPASAQESRQEARAATGHSRRKPSEKPLGSQVQPQHSSKANGSDRTGGTDRTEHFRAMIEEFVASKEAQLEFPTSLSSHDRLRVHQLAEEFGLKHDSTGEGKARHITVSRRSPAGSGSATPQPPSPPSPAQAEPEPQVEQPVGQPHGSTQLDLKALHLERLQRQQGCQAQSQLGGGSRPQKAPQKKKKKEPKGPAMALPSEEDFDALVSAVVKADNTCSFTKCSASTTTLGQFCMHCSRRYCLSHHLPEIHGCGEKARAHARQRISREGVLYAGSGTKDRALDPAKRAQLQRKLDKKLGELSSQRTSKKKEKERGT