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IGF2BP3

Gene
IGF2BP3
Protein
Insulin-like growth factor 2 mRNA-binding protein 3
Organism
Gallus gallus
Length
584 amino acids
Function
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity).
Similarity
Belongs to the RRM IMP/VICKZ family.
Mass
64.373 kDa
Sequence
MNKLYIGNLGENVSPLDLESLFKDSKIPFSGQFLVKTGYAFVDCPDESWAMKAIEALSGKVELHGKLIEVEHSVPKRQRSRKLQIRNIPPHLQWEVLDSLLAQYGTVENCEQVNTDTETAVVNVTYGNKDQARQAIEKLNGFQLENYSLKVAYIPDEMAAQQPPQQHPQGRRGFGQRGPPRQGSPSATTRQKPQSDVPLRMLVPTQFVGAIIGKEGATIRNITKQTQSKIDIHRKENAGAAEKPITIHSTPEGCSTACKIIMEIMQKEAQDTKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGSIETCAKAEEEIMKKIRESYENDIAAMNLQAHLIPGLNLNALGLFPPSSSGIPPPAVSVASAAAAASYPPFGQQPESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPAEGPDAKLRMVIITGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLEAHIKVPSYAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYACQLAQRKIQEILAQVRRQQQQQKTLQSGQPQPRRK

Gene
igf2bp3
Protein
Insulin-like growth factor 2 mRNA-binding protein 3
Organism
Danio rerio
Length
582 amino acids
Function
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Involved in the neuronal crest migration.
Similarity
Belongs to the RRM IMP/VICKZ family.
Mass
63.352 kDa
Sequence
MNKLYIGNVSEQASALDLESIFEQWKIPFSAPFLVKSGYAFVDCPDEKVAMRAIDTLSGKVELHGKVLEVEHSVPKRQRSCKLQIRNIPPHMQWEVLDGLLAQYGTVESCEQVNTDTETAVVNVRYGAKDQAREAMDKLNGFLMENYALKVSYIPDETAAADAPAVGGRRGFNPRGPPRQGSPSLGARPKLQSDVPLRLLVPTQFVGAIIGKEGATIRNITKQTHSKIDIHRKENAGAAEKPITVHSTPEGCSSACRNIMEIMQKEAIDTKITEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQDLTLYNPERTITVKGTLDACAKAEEEIMKKVRESYENDVAAMHLQSNLIPGLNLNALGLFPGAASGGISPSVVSGPPPGAQAGYQSFGAQMESETVHLFIPALAVGAIIGKQGQHIKQLSRFAGASIKIAPADGIDAKQRMVIISGPPEAQFKAQGRIFGKLKEENFFGPKEEVKLEAHIKVPSFAAGRVIGKGGKTVNELQNLTSAEVVVPRDQTPDENDQVVVKITGHFYASQLAQRKIQEIISQVRRQQQPKPSAAGPPVARRK

Gene
IGF2BP3
Protein
Insulin-like growth factor 2 mRNA-binding protein 3
Organism
Homo sapiens
Length
579 amino acids
Function
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Similarity
Belongs to the RRM IMP/VICKZ family.
Mass
63.705 kDa
Sequence
MNKLYIGNLSENAAPSDLESIFKDAKIPVSGPFLVKTGYAFVDCPDESWALKAIEALSGKIELHGKPIEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDEMAAQQNPLQQPRGRRGLGQRGSSRQGSPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGNVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSAMTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQNLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK

Gene
Igf2bp3
Protein
Insulin-like growth factor 2 mRNA-binding protein 3
Organism
Mus musculus
Length
579 amino acids
Function
RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Similarity
Belongs to the RRM IMP/VICKZ family.
Mass
63.575 kDa
Sequence
MNKLYIGNLSDHAGPADLESVFKDAKIPVAGPFLVKTGYAFVDCPDEGWALKAIEALSGKMELHGKPMEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDETAAQQNPSPQLRGRRGPGQRGSSRQASPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENTGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGSVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSTLTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQSLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK