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IFT20

Gene
IFT20
Protein
Intraflagellar transport protein 20 homolog
Organism
Bos taurus
Length
156 amino acids
Function
Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Mass
17.847 kDa
Sequence
MTHLSLADPVREPLFSGEAGRQTAMAKDILAEAGLHFDELNKLRVLDPEVSQQTIELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKMQLERYRVEYEALCKVEAEQNEFIDQFIFQK

Gene
ift20
Protein
Intraflagellar transport protein 20 homolog
Organism
Danio rerio
Length
132 amino acids
Function
Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
Mass
15.287 kDa
Sequence
MAKDPLAEAGLHFDELNKLRVLEPDVSQKTTELKEECEEFVDKIGQFQKIVGGLIELVDELAKEAETEKMKAIGARNLLKSVEKQREAQHQQLQALIAEKKMQLERYRIEYEALQKVEAEQSEFIDQFILQK

Gene
IFT20
Protein
Intraflagellar transport protein 20 homolog
Organism
Homo sapiens
Length
132 amino acids
Function
Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity).
Mass
15.281 kDa
Sequence
MAKDILGEAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKMQLERYRVEYEALCKVEAEQNEFIDQFIFQK

Gene
Ift20
Protein
Intraflagellar transport protein 20 homolog
Organism
Mus musculus
Length
132 amino acids
Function
Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (PubMed:27682589). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (PubMed:24089209).
Mass
15.237 kDa
Sequence
MAKDILGEAGLHFDELNKLRVLDPEVTQQTVELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKTQLERYRVEYEALCKVEAEQNEFIDQFIFQK

Gene
ift20
Protein
Intraflagellar transport protein 20 homolog
Organism
Xenopus tropicalis
Length
132 amino acids
Function
Involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella.
Mass
15.339 kDa
Sequence
MARDSLSDAGLHFDELNKLRILDPDVAQQTNELKEECRDFVDKIGHFQKVVGGLIELVDELAKETENEKMKAIGARNLLKSIAKQREAQQQQLYALIAEKKMQLERYRIEYEALCKVEAEQNEFIDQFNLQK