Function
Key player in antiviral response. Induces expression of TLRs, including that of TLR3, TLR9 and TLR8a1, and that of cytosolic pattern recognition receptors, including DDX58/RIG-1, IFIH1/MDA5 and DHX58/LGP2. Also induces MX1 and its own expression. In the presence of intracellular IFNAR2 (iIFNAR2) and IFNAR1B, intracellular isoform 3 may mediate STAT1 and STAT2 phosphorylation and induction of EIF2AK2, MX1 and RSAD2.