Protein
Immediate-early protein IE-0
Organism
Autographa californica nuclear polyhedrosis virus
Function
Putative viral E3 ligase that plays an essential regulatory role in both viral DNA replication and transcriptional transactivation. The role in transcription has been shown to include activation of gene expression from early viral promoters. Promotes also the efficient egress of nucleocapsids from the host nucleus. May act as an E3 ligase that promotes ubiquitination of nucleocapsids proteins by vUbi and subsequent viral egress for the host nucleus.
Sequence
MIRTSSHVLNVQENIMTSNCASSPYSCEATSACAEAQQVMIDNFVFFHMYNADIQIDAKLQCGVRSAAFAMIDDKHLEMYKHRIENKFFYYYDQCADIAKPDRLPDDDGACCHHFIFDAQRIIQCIKEIESAYGVRDRGNVIVFYPYLKQLRDALKLIKNSFACCFKIINSMQMYVNELISNCLLFIEKLETINKTVKVMNLFVDNLVLYECNVCKEISTDERFLKPKECCEYAICNACCVNMWKTATTHAKCPACRTSYK