Protein
Major viral transcription factor ICP4 homolog
Organism
Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997)
Function
This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. It is required for the switch from immediate-early to early mode of gene expression (By similarity).
Similarity
Belongs to the herpesviridae ICP4 family.
Sequence
MFWHQPRQQQLRQLQRAASGAGKHQRRSPPQTLGDDGDAAAQVPPSPTGALLAFLNQHASEEGGAAAASADGRVSVSPGFCSSILPEHSQDLFAFSDPTSASPQPVPMDASLSLFTPPVPDCGRDVGEEAEGAVAPSWRAPLPAPQWRPVHGPSWWLSSSSPSGSSRGSVTSPQYSGEETSDAASGAPTPPPQSSGSSYVYGQALADLMAMIQEIPAPPRSVPDCRRGEPVSEDGMADRCETDASCYTTDEPMEAEPSEPAGGVSWLGERADRMRADQSPRGLGAEPHVAEAGRPSSCVGEERADVVAIAAVEERKEAARRSPDAERNDDEEEYESLPCAQEFFTSQELAEINARAIAESDEAEDEDAGSPAARSQSSPFPSLGPAVFVLAPTSAKSSRGMRKKAIAVSRVVPDNDGEPDPCADGPGRDHVSSAQSAGANGALETETSVPRSATAPAGAVAACAQNTKRGYWRGAAAGHAEEETDSDDEDVLVVDVSACAEPFESFAQRQQPRQQQHAPRNKPARQRLRAGAIVAAASGNTLTVPSEPPHPSLAPLWKMLNLWLSEEWPAQGGGQDEGEAAVSASLLAPGSLPELPDMCPRVAVGIISHALAVDLSAPGGRITVDEALLPKPPAADYVYYGKTGYRPSMAAHPDVRRAAEEFSASDAAARVYVEEFGMAVEQHERLVAEFMLQPLSRVSHSYGGSRLNKTEKNLCKICLPPDGGDDRDGGGKSRGGRGGGSKDASRTAMATGVPHIVHAMRDGRAALALPHLMDVIRVCRRYDASQKTYLLSCLRLAFAPLVFPGASPPVGADDSPWPTSPIRECAAALREGFRALNDIRAEQDPPADERSRELALPLDRAITAARRVAATAAGLLNAVGASVVHDGRVGLPAFFLRGVTERREDLFSAARRCPRALYSWERSMRATTAALWGHLASRGPIAAPVADLEELSQALSAVLSVTSVPDGGDVRYAFAEADEGWRALAVMLGGGAVRTSSGESGDAETDAAYALLAPGKQSSAGVNHPRGRPGRATASSPRTPASRPPHGSAAAPPSGRDSPPGALNVPEAAEEELRLAAARDTTGDLLSDEAGTDDDGDAPVVISYVGPSSPPGVEDPSPDGLAALRPLPEGYVPRPGDVLRGDPGADENDDDARAPCRVGDASPPRQLPSSSSFASSSLASAVPGDPYLPRSVAEPTLCRLAEHLQSDDGWTRAFANDPVGLAEFARRSTPGRRLGGQRRLDQLLSWTRRHSPRRRYSLIVLVSEKRPGDFRERAYAAAALAGRACVPGSACDPETWRDAEDHPSPSADAQSPLRSRPSRDCFPPRIAQPEASDDDDVGEGGTALLSAGDIGFAGAVESMLRRALSRQGQACAVVDARDDKDVLSAAAPRFPRGKPGLIYLRVAPPSEACVANLPSLGPSASPHRGVGGKHRDKRPCLAEGTPSAPSCRDAARATAPLSGDPVAHRLLMHRPAKPLVGEEACAALLGGKAGRRGQDVPLPFLTAATLRKVARVARELDPGWGHGDLGCESAVVFPPAAPPGPELADRHADRRRSTKGPQRPGGKRPRSSSSSSSASHDRSPSSSSRRRDGRPSSRRRPSRRMSARPPSRPPAAVILRASWRYAEEVAREMLDAAASRFDEADGEDPLPPAACGGKPIAPETLVALCEQRGRGPTSLPRAPTPRSGEALAAPRRSGAKDPRQGQYCPSARRSEAPHSPSPRDVALRLLERQQELNRQLLLELRRGSCEISPSPRRRDAEGRRFGCRQDDDDGYDYEGGRESPERVLGRRQSRRDSVPVRRRSGAANCGGRWMISAGRSSSSSSSSSSSSSSSPSSRPSRSATPSLSPSPSPPRRAPVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSPDGTAPGDAPLNLEDGPGRGRPIWTPSSATTLPSRSGPEDSVDETETEDSAPPARLAPSPLETSRAEDSEDSEYPEYSNPRLGKSPPALKSREARRPSSKQPRRPSSGKNGHTDVSAASAFFLGRPAPGSCGRRPLGARVRGGTER