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ICP4

Gene
ICP4
Protein
Major viral transcription factor ICP4 homolog
Organism
Gallid herpesvirus 2 (strain GA)
Length
1415 amino acids
Function
This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. It is required for the switch from immediate-early to early mode of gene expression.
Similarity
Belongs to the herpesviridae ICP4 family.
Mass
154.937 kDa
Sequence
MVELGFPAYGPAIEKRVRPLYKALCDWRAAVTLAARRRFQQLRCNANMDDDGQPMFPPLPVPDWNNPSTDWRPSPPRSGPKKDFCGDLPAPLTSGPRLTTPSSGRMSELPHTTSSPRSSPRPRGPETSPSNEHIIISPPRNPPSNTTHRNVGHVSRSPSSSSSSSSSSSPSSSSLIVLSSPSSSRSPSPSPPRPRADSSSRPRRGRGSNRGGRSGPQSKGRKASPRTRKLEDEDYLPQETANRRGGGRPRGRPPKSGRAVQRNDIQVTSSSGLADTSPYDLCGSVWWEVPLPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFHKSMKVNPLNWMHHGKLSPADAALNHIYVQKFQSSYDSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSLKKAYASMAFPDNSSETEKGISSKPSTSPSVLITTSTQTTASPHAPKIDVTAIHGRVYQSVVDLSRCLADGSLDDPEFSFAGCTRPDCCVEEFDAARPLEELADACVLACDSVVAALLCGPDGPHRVAKMLSFYDSRITPHVPDSQQWEKCRILLVSWYNELSDLRAAVYGAYGNTPTSQHLDERALAARVVSLIAETIGPLVRQDPDRAWVRMGSRDITSLLLRDWRGTNDGDPGLVKAKHLRRTAELLNDGRSSKGTYGVFAPPRRPDQLFRGPGRPRRSTSSSQSASDKSPIKSTHRHTSDPIPISTPRPERDPAGTPHENTMSGPVQPAANGHSCSSTPTPAKKGNKTSSDTISLKDPTKTRIKASAKAQTDETLPETSTAHPSAMDQSSSLERKTLYTGPAVSSKERRRSAQSSTPSDIGGVSRKRKSAPEQYKQGLQTPLPMPEPSVGQTLLDPTTTTHDILSSSLPNRSCSSSPSPSKRPYHPSCYSPTDIMTGALVGPRGRQDRAAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADIARVANALPGKYNSNEIITSAASEAFHTATSKLRARTAWMRYQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPPGGLKFDNKRGGLSFLLAAFSNRLCLPKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATRYMKCIISPRSQCCVRWPGLRDFGTTIITSRDVVGPLTLMDLEQYYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLFYFAAVKHVRPDFLCGETYSNRAARKWGLCAPLRPIYVIESKMNAIVSPSFLHPTARNLCRSVILPPDPEARPVVVHIPEGTCSALAEDMVASIRSSCITWGQHEEGGPETTAQENSDIRAMKVRPPTKPPYMSPLNIGNRDTTFTD

Gene
ICP4
Protein
Major viral transcription factor ICP4 homolog
Organism
Human herpesvirus 2 (strain HG52)
Length
1318 amino acids
Function
Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription.
Similarity
Belongs to the herpesviridae ICP4 family.
Mass
135.104 kDa
Sequence
MSAEQRKKKKTTTTTQGRGAEVAMADEDGGRLRAAAETTGGPGSPDPADGPPPTPNPDRRPAARPGFGWHGGPEENEDEADDAAADADADEAAPASGEAVDEPAADGVVSPRQLALLASMVDEAVRTIPSPPPERDGAQEEAARSPSPPRTPSMRADYGEENDDDDDDDDDDDRDAGRWVRGPETTSAVRGAYPDPMASLSPRPPAPRRHHHHHHHRRRRAPRRRSAASDSSKSGSSSSASSASSSASSSSSASASSSDDDDDDDAARAPASAADHAAGGTLGADDEEAGVPARAPGAAPRPSPPRAEPAPARTPAATAGRLERRRARAAVAGRDATGRFTAGRPRRVELDADAASGAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEARARFEASGAPAPVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVAPGDVALDQACFRISGAARNSSSFISGSVARAVPHLGYAMAAGRFGWGLAHVAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAALTGARTPDDGGDANRHDGDDARGKPAAAAAPLPSAAASPADERAVPAGYGAAGVLAALGRLSAAPASAPAGADDDDDDDGAGGGGGGRRAEAGRVAVECLAACRGILEALAEGFDGDLAAVPGLAGARPAAPPRPGPAGAAAPPHADAPRLRAWLRELRFVRDALVLMRLRGDLRVAGGSEAAVAAVRAVSLVAGALGPALPRSPRLLSSAAAAAADLLFQNQSLRPLLADTVAAADSLAAPASAPREARKRKSPAPARAPPGGAPRPPKKSRADAPRPAAAPPAGAAPPAPPTPPPRPPRPAALTRRPAEGPDPQGGWRRQPPGPSHTPAPSAAALEAYCAPRAVAELTDHPLFPAPWRPALMFDPRALASLAARCAAPPPGGAPAAFGPLRASGPLRRAAAWMRQVPDPEDVRVVILYSPLPGEDLAAGRAGGGPPPEWSAERGGLSCLLAALGNRLCGPATAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLAGACDRRLIVVNAVRAADWPADGPVVSRQHAYLACEVLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGANVRYRVRTRFGPDTLVPMSPREYRRAVLPALDGRAAASGAGDAMAPGAPDFCEDEAHSHRACARWGLGAPLRPVYVALGRDAVRGGPAELRGPRREFCARALLEPDGDAPPLVLRDDADAGPPPQIRWASAAGRAGTVLAAAGGGVEVVGTAAGLATPPRREPVDMDAELEDDDDGLFGE

Gene
ICP4
Protein
Major viral transcription factor ICP4
Organism
Human herpesvirus 1 (strain 17)
Length
1298 amino acids
Function
Plays an essential role in the regulation of viral gene expression by both activating and repressing host RNA polymerase II-mediated transcription. Binds with high affinity to the sequence 5'-ATCGTC-3'. Activates transcription by recruiting a form of the host TFIID to promoters and stabilizing the pre-initiation complex formation. Negatively regulates its own transcription. This immediate early (IE) protein is absolutely necessary for the transition from IE transcription to later viral gene transcription.
Similarity
Belongs to the herpesviridae ICP4 family.
Mass
132.844 kDa
Sequence
MASENKQRPGSPGPTDGPPPTPSPDRDERGALGWGAETEEGGDDPDHDPDHPHDLDDARRDGRAPAAGTDAGEDAGDAVSPRQLALLASMVEEAVRTIPTPDPAASPPRTPAFRADDDDGDEYDDAADAAGDRAPARGREREAPLRGAYPDPTDRLSPRPPAQPPRRRRHGRWRPSASSTSSDSGSSSSSSASSSSSSSDEDEDDDGNDAADHAREARAVGRGPSSAAPAAPGRTPPPPGPPPLSEAAPKPRAAARTPAASAGRIERRRARAAVAGRDATGRFTAGQPRRVELDADATSGAFYARYRDGYVSGEPWPGAGPPPPGRVLYGGLGDSRPGLWGAPEAEEARRRFEASGAPAAVWAPELGDAAQQYALITRLLYTPDAEAMGWLQNPRVVPGDVALDQACFRISGAARNSSSFITGSVARAVPHLGYAMAAGRFGWGLAHAAAAVAMSRRYDRAQKGFLLTSLRRAYAPLLARENAALTGAAGSPGAGADDEGVAAVAAAAPGERAVPAGYGAAGILAALGRLSAAPASPAGGDDPDAARHADADDDAGRRAQAGRVAVECLAACRGILEALAEGFDGDLAAVPGLAGARPASPPRPEGPAGPASPPPPHADAPRLRAWLRELRFVRDALVLMRLRGDLRVAGGSEAAVAAVRAVSLVAGALGPALPRDPRLPSSAAAAAADLLFDNQSLRPLLAAAASAPDAADALAAAAASAAPREGRKRKSPGPARPPGGGGPRPPKTKKSGADAPGSDARAPLPAPAPPSTPPGPEPAPAQPAAPRAAAAQARPRPVAVSRRPAEGPDPLGGWRRQPPGPSHTAAPAAAALEAYCSPRAVAELTDHPLFPVPWRPALMFDPRALASIAARCAGPAPAAQAACGGGDDDDNPHPHGAAGGRLFGPLRASGPLRRMAAWMRQIPDPEDVRVVVLYSPLPGEDLAGGGASGGPPEWSAERGGLSCLLAALANRLCGPDTAAWAGNWTGAPDVSALGAQGVLLLSTRDLAFAGAVEFLGLLASAGDRRLIVVNTVRACDWPADGPAVSRQHAYLACELLPAVQCAVRWPAARDLRRTVLASGRVFGPGVFARVEAAHARLYPDAPPLRLCRGGNVRYRVRTRFGPDTPVPMSPREYRRAVLPALDGRAAASGTTDAMAPGAPDFCEEEAHSHAACARWGLGAPLRPVYVALGREAVRAGPARWRGPRRDFCARALLEPDDDAPPLVLRGDDDGPGALPPAPPGIRWASATGRSGTVLAAAGAVEVLGAEAGLATPPRREVVDWEGAWDEDDGGAFEGDGVL