Protein
Major viral transcription factor ICP4 homolog
Organism
Gallid herpesvirus 2 (strain GA)
Function
This IE protein is a multifunctional protein capable of migrating to the nucleus, binding to DNA, trans-activating other viral genes, and autoregulating its own synthesis. It is required for the switch from immediate-early to early mode of gene expression.
Similarity
Belongs to the herpesviridae ICP4 family.
Sequence
MVELGFPAYGPAIEKRVRPLYKALCDWRAAVTLAARRRFQQLRCNANMDDDGQPMFPPLPVPDWNNPSTDWRPSPPRSGPKKDFCGDLPAPLTSGPRLTTPSSGRMSELPHTTSSPRSSPRPRGPETSPSNEHIIISPPRNPPSNTTHRNVGHVSRSPSSSSSSSSSSSPSSSSLIVLSSPSSSRSPSPSPPRPRADSSSRPRRGRGSNRGGRSGPQSKGRKASPRTRKLEDEDYLPQETANRRGGGRPRGRPPKSGRAVQRNDIQVTSSSGLADTSPYDLCGSVWWEVPLPPPGRCWFGGLGGHRQALTDSPEIVEAIHRFNTSHGPVPVYVEEMKDYAKQYDALVNSLFHKSMKVNPLNWMHHGKLSPADAALNHIYVQKFQSSYDSPGAAVTGTVNRCIPHIAGAMKERKLLWAFPHIAASIAMTRRYCKDQKTFLFRSLKKAYASMAFPDNSSETEKGISSKPSTSPSVLITTSTQTTASPHAPKIDVTAIHGRVYQSVVDLSRCLADGSLDDPEFSFAGCTRPDCCVEEFDAARPLEELADACVLACDSVVAALLCGPDGPHRVAKMLSFYDSRITPHVPDSQQWEKCRILLVSWYNELSDLRAAVYGAYGNTPTSQHLDERALAARVVSLIAETIGPLVRQDPDRAWVRMGSRDITSLLLRDWRGTNDGDPGLVKAKHLRRTAELLNDGRSSKGTYGVFAPPRRPDQLFRGPGRPRRSTSSSQSASDKSPIKSTHRHTSDPIPISTPRPERDPAGTPHENTMSGPVQPAANGHSCSSTPTPAKKGNKTSSDTISLKDPTKTRIKASAKAQTDETLPETSTAHPSAMDQSSSLERKTLYTGPAVSSKERRRSAQSSTPSDIGGVSRKRKSAPEQYKQGLQTPLPMPEPSVGQTLLDPTTTTHDILSSSLPNRSCSSSPSPSKRPYHPSCYSPTDIMTGALVGPRGRQDRAAFRQFPVGTVIGQTPPQSVLNAYCPNGAFVELVEFARIPEPWQEVLRYSPEAMADIARVANALPGKYNSNEIITSAASEAFHTATSKLRARTAWMRYQQESPDDVSIVVLYSPLPGEHLFCVPAPDTPPGGLKFDNKRGGLSFLLAAFSNRLCLPKSSAWAGRWKAAPDISPLTRMGVLFLSTEDLGYQGAVEYLQRQCMKRKKKLIIMDTVEDRYRLPNGPCIIEEATRYMKCIISPRSQCCVRWPGLRDFGTTIITSRDVVGPLTLMDLEQYYYCEIGIEDSTINLCCTGNVRYTVETRLEDVSCVPTTPLFYFAAVKHVRPDFLCGETYSNRAARKWGLCAPLRPIYVIESKMNAIVSPSFLHPTARNLCRSVILPPDPEARPVVVHIPEGTCSALAEDMVASIRSSCITWGQHEEGGPETTAQENSDIRAMKVRPPTKPPYMSPLNIGNRDTTFTD