IBTK

Inhibitor of Bruton tyrosine kinase

1353 amino acids

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription.

150.528 kDa

MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC

Ibtk

Inhibitor of Bruton tyrosine kinase

1352 amino acids

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity).

149.569 kDa

MDAATPDCTSKCRSLKHALDVLSVVTKGSESQIKSFLARYCYNAATVKDAFGRNAGHLASSCGKKGVLDWLIEKGVDLLVKDKESGWTALHRSVFYGHIDCVWSLLKHGVSLYMQDKEGLSPLDLLMKDRPTHVVFKDTDPTEVYTWGDNTNFTLGHGSQNSKHHPELLDLFSRSGVYVKQVVLCKFHSVFLSQKGQVYTCGHGRGGRLGHGDEQTCLVPRLVEGLSGHNCSQVAAAKDHTVVLTDDGCVYTFGLNMFHQLGIIPPPASCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTLGLNGGQLGHLLDPNGEKCVTTPRQVSALHHKDIAVSLVAASDGATVCVTTRGDIYLLADYQCKKMATKQLNLKKVLVSGGCMEYKVDPEHLTENGGQKICVLAMDGAGRVFCWRSISSSLKQCRWAYPRQVSISDIALNRNEILFVTQDGEGFKGKWFEDKRKNSEKKADILPNLHHSSSDVSCVPDTNSVYERIRLEKLPFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPVVSSSSFFEEFGKLLRETDEMDSFHDVTFQVGNRHFPAHKYILAVRSDFFQKLFLSDGSSLELTDVYQKDEDAAGCHLFVVEKVHPDLFEYLLQFMYTDTCDLLTHGFKPRMIVKRKAEDCEGSPDSHLHTVNCHVDDKQKSAFEVYRSNQAHTLSERQKSKPKSSKKGKGVGDDDPVRMLQSVAKKFGLSNLSSRLEGVRLENEKINVIAKKTGNKLKLSQKKCSFLYDVTMKSVDGKEFSCHKCVLCARLEYFHSMLSRSWIEASSCAALEMPIQSEILKVILDYLYTDEAVVIKESQNVDFVCSVLVVADQLLITRLKEICEVALTENLTLKNAAMLLEFAALYNAGQLKLSCLQFIGLNMAALLEARSLDVLSEDVLKDLSIFYRKMIPAMERRVITPYQDGPDISSMQVEDGEVFFKEEINMEPNYSETMFKKAKTRAKKKPRKRSDSSGGYTLSDVIQSPPSAGLLKSAKTNSVESLPELLTSDSEGSYAGVASPRDLQSPDFTAGFHSDKVEGKAKPYVNGIPPPCTREDVKPWEKSPTTKSAPQFIPSNRVDTAASSSWLAGSCSPVSPPVVDLRTIMETEENRQKYGAAPKSNLGKIISHGIKLSQKQRKMIALTTKENNSGTNSMEAILTAPSKSPKPANAWAPLHSPLSRSFRDFLLEEKKPVPGYGSGDHVKKVCFKGTENSPALNVARCSTHGTPGLESNHVSDFPLLDSPNPWQSSSLAASPAVAPVTFASIVEEERQQEAALIRSREKPLALIQVEEHAIQDLLVFYEAFGNPEEFVVVERAPQGPLAVPMWNKHGC

ibtk

Inhibitor of Bruton tyrosine kinase

1339 amino acids

Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development.

149.341 kDa

MERVWPECTTRCRSLQHALDVISVVTRASEQHIKVFLSSYCCNAVTLKDDFGRNATHIAASCGKKNVLDWLITGKGVDLAVKDKESGWTALHRSIFYGHIDCALSLLKHGSNLYIQDKDGYTPLDLVMKDRPPHIVFKTSDPTELYTWGDNVNFTLGHGTQQSKHHPELVEMFPRSGVYIKQMVLCKFHSVFLSQKGQVYTCGHGQGGRLGHGDELTCLVPRLVEGLRGHPCTQVAGAKDHTVVLTEDGYVYTFGLNTFHQLGIQPPPPNSNVPRQIQAKTMKGKTVLGVAAGRFHTVLWTKDAVYTVGLNGGQLGYLQDPNGEKFVSCPRQVSALHHKDINITLVSASDGATVCVSERGDIYLLSEYQCKKLASKQLNLKKVLVSGGILEHKAAPEHLKENGGQPASVFALDQAGRVFCWKSPGSSLKQCWWVYGRQLFMSDVALNKNEIMFVTQDGEGFTGKWMLEKKKKENTISNIMCHSDSQNVYEKISMQKLPFVHRAVSVATDPSGCNFAVLQSDPKTSLFEVPSVSSSVFAEDFEKLLNEANETDSIHDVTFQVGTKIFPAHKYILALRCDFFSKLFSSGEINSLDFPEVHQKGEDAAGCDLFVIEKIPPELFSHVLQFIYSDTCDMLLQGHKPKLWHKEENENTIICNFQKMGFREDIEGKSAYEVYKNSRICAENEKQKGKTKQSKKTRSIGDETSPVKMLQNTAKKFGLSNLSSRLDGVRYENGRINVFHKKSENKLRFNQKKCSSHYDVMMKSEDGKEFHCHKCVLCARLEYFNSMLSSSWIEASCCSQLEMPIHSDVLQVILDYIYTDEVLTVKESANVEFVCNVLVIADQLLIVRLKEICEVTIAERITLKNAAELLEFAALYNADQLKLSCLQFVGLNMGALLEARSLDVLSDDVLKDLSEAYRKMIPSMNKRIITPYLDGPDISILQSEDIESLISVQDDIYSYQITQEATLKKSKAKPKKKQRKRLDSSGGYNLSDIIQSPTSTGFVKPEKTNSVESLQDLLTSDSEGSFVGASSPRDLQSPDLFPVFTHETKETICVERNRSSPPVANGAASTKMPIPTTSSPKAIPMSRITPSTSPNWVAMPCSPASPVTMDLRAIMELEENIQKCGAMPKLNAGGTKPGTHVMKLSQKQRKMMAMSSKESNNENKPAKVTVAPTTIKSPAKTWAAAFHLGENKSFRDLLLEEKQSVTSFPSLSSDVKKSKHTEELDPSELARRPSGTLNQEAKLKCDVPNQDNSNPWHLTLSKNNASSAPVTFTAIVEEEEKQEAALIRSREKPLALIQIEERAIQDLLLHYQAIDNPEEYITIERAAQIPMATPMWNKH