Protein
E3 ubiquitin-protein ligase IAP-3
Organism
Orgyia pseudotsugata multicapsid polyhedrosis virus
Function
RING-finger E3 ubiquitin ligase required to prevent cellular apoptosis in infected cells. Ubiquitinates and subsquently targets host pro-apoptotic cellular proteins such as HID for degradation by the proteasome.
Similarity
Belongs to the IAP family.
Sequence
MSSRAIGAPQEGADMKNKAARLGTYTNWPVQFLEPSRMAASGFYYLGRGDEVRCAFCKVEITNWVRGDDPETDHKRWAPQCPFVRNNAHDTPHDRAPPARSAAAHPQYATEAARLRTFAEWPRGLKQRPEELAEAGFFYTGQGDKTRCFCCDGGLKDWEPDDAPWQQHARWYDRCEYVLLVKGRDFVQRVMTEACVVRDADNEPHIERPAVEAEVADDRLCKICLGAEKTVCFVPCGHVVACGKCAAGVTTCPVCRGQLDKAVRMYQV