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HYR1

Gene
HYR1
Protein
Hyphally-regulated protein
Organism
Candida albicans
Length
937 amino acids
Function
Nonessential component of the hyphal cell wall.
Mass
93.7 kDa
Sequence
MKVVSNFIFTILLTLNLSAALEVVTSRIDRGGIQGFHGDVKVHSGATWAILGTTLCSFFGGLEVEKGASLFIKSDNGPVLALNVALSTLVRPVINNGVISLNSKSSTSFSNFDIGGSSFTNNGEIYLDSSGLVKSTAYLYAREWTNNGLIVAYQNQKAAGNIAFGTAYQTITNNGQICLRHQDFVPATKIKGTGCVTADEDTWIKLGNTILSVEPTHNFYLKDSKSSLIVHAVSSNQTFTVHGFGNGNKLGLTLPLTGNRDHFRFEYYPDTGILQLRADALPQYFKIGKGYDSKLFRIVNSRGLKNAVTYDGPVPNNEIPAVCLIPCTNGPSAPESESDLNTPTTSSIETSSYSSAATESSVVSESSSAVDSLTSSSLSSKSESSDVVSSTTNIESSSTAIETTMNSESSTDAGSSSISQSESSSTAITSSSETSSSESMSASSTTASNTSIETDSGIVSQSESSSNALSSTEQSITSSPGQSTIYVNSTVTSTITSCDENKCTEDVVTIFTTVPCSTDCVPTTGDIPMSTSYTQRTVTSTITNCDEVSCSQDVVTYTTNVPHTTVDATTTTTTSTGGDNSTGGNESGSNHGPGNGSTEGSGNGSGAGSNEGSQSGPNNGSGSGSEGGSNNGSGSDSGSNNGSGSGSNNGSGSGSTEGSEGGSGSNEGSQSGSGSQPGPNEGSEGGSGSNEGSNHGSNEGSGSGSGSGSNNGSGSGSQSGSGSGSQSGSESGSNSGSNEGSNPGAGNGSNEGSGQGSGNGSEAGSGQGSGPNNGSGSGHNDGSGSGSNQGSNPGAGSGSGSESGSKAGSHSGSNEGAKTDSIEGFHTESKPGFNTGAHTDATVTGNSVANPVTTSTESDTTISVTVSITSYMTGFDGKPKPFTTVDVIPVPHSMPSNTTDSSSSVPTIDTNENGSSIVTGGKSILFGLIVSMVVLFM

Gene
HYR1
Protein
Hyphally regulated cell wall protein 1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
919 amino acids
Function
GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through confering resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin-forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections.
Similarity
Belongs to the HYR1/IFF family.
Mass
91.917 kDa
Sequence
MKVVSNFIFTILLTLNLSAALEVVTSRIDRGGIQGFHGDVKVHSGATWAILGTTLCSFFGGLEVEKGASLFIKSDNGPVLALNVALSTLVRPVINNGVISLNSKSSTSFSNFDIGGSSFTNNGEIYLASSGLVKSTAYLYAREWTNNGLIVAYQNQKAAGNIAFGTAYQTITNNGQICLRHQDFVPATKIKGTGCVTADEDTWIKLGNTILSVEPTHNFYLKDSKSSLIVHAVSSNQTFTVHGFGNGNKLGLTLPLTGNRDHFRFEYYPDTGILQLRAAALPQYFKIGKGYDSKLFRIVNSRGLKNAVTYDGPVPNNEIPAVCLIPCTNGPSAPESESDLNTPTTSSIETSSYSSAATESSVVSESSSAVDSLTSSSLSSKSESSDVVSSTTNIESSSTAIETTMNSESSTDAGSSSISQSESSSTAITSSSETSSSESMSASSTTASNTSIETDSGIVSQSESSSNALSSTEQSITSSPGQSTIYVNSTVTSTITSCDENKCTEDVVTIFTTVPCSTDCVPTTGDIPMSTSYTQRTVTSTITNCDEVSCSQDVVTYTTNVPHTTVDATTTTTTSTGGDNSTGGNESGSNHGSGAGSNEGSQSGPNNGSGSGSEGGSNNGSGSGSDSGSNNGSGSGSNNGSGSGSNNGSGSGSGSTEGSEGGSGSNEGSNHGSNEGSGSGSGSQTGSGSGSNNGSGSGSQSGSGSGSQSGSESGSNSGSNEGSNPGAGNGSNEGSGQGSGNGSEAGSGQGSGPNNGSGSGHNDGSGSGSNQGSNPGAGSGSGSESGSNAGSHSGSNEGAKTDSIEGFHTESKPGFNTGAHTDATVTGNSVANPVTTSTESDTTISVTVSITSYMTGFDGKPKPFTTVDVIPVPHSMPSNTTDSSSSVPTIDTNENGSSIVTGGKSILFGLIVSMVVLFM

Gene
HYR1
Protein
Glutathione peroxidase-like peroxiredoxin HYR1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
163 amino acids
Function
Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator YAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging, being the most active of three closely related S.cerevisiae peroxiredoxins (GPX1, GPX2, and HYR1/GPX3) with respect to peroxide and lipid hydroperoxide reduction. The three enzymes are not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, HYR1/GPX3 is directly oxidized at Cys-36 to form a cysteine sulfenic acid (-SOH). Cys-36-SOH then forms either an intramolecular disulfide bond (Cys-36 with Cys-82) or a transient, intermolecular disulfide bond with 'Cys-598' of YAP1, which is further resolved into a YAP1 intramolecular disulfide bond ('Cys-303' with 'Cys-598'), which causes its nuclear accumulation and activation, and a reduced Cys-36 in HYR1/GPX3.
Similarity
Belongs to the glutathione peroxidase family.
Mass
18.641 kDa
Sequence
MSEFYKLAPVDKKGQPFPFDQLKGKVVLIVNVASKCGFTPQYKELEALYKRYKDEGFTIIGFPCNQFGHQEPGSDEEIAQFCQLNYGVTFPIMKKIDVNGGNEDPVYKFLKSQKSGMLGLRGIKWNFEKFLVDKKGKVYERYSSLTKPSSLSETIEELLKEVE