Protein
Alpha-ketoglutarate semialdehyde dehydrogenase
Organism
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
Function
Alpha-ketoglutarate semialdehyde dehydrogenase involved in the degradation of D-xylose, a major component of hemicelluloses such as xylan. Catalyzes the fifth reaction in the xylose utilization pathway through dehydratation of alpha-ketoglutarate semialdehyde (2,5-dioxopentanoate) into alpha-ketoglutarate.
Similarity
Belongs to the aldehyde dehydrogenase family.
Sequence
MTDPSKNYVNGEWVTSETGETTEVTNPANPSEVVAAYQHSNENDAAAAVDAAVAAEDEWRNTPGPERGRILREAGTLLAQRKDELTEILTAEEGKARPEAAGEVQRAIDIFHYFSSKAADLGGTKKGASGPNTNLYTRQEPVGVAALITPWNYPIAIPAWKLAPALAAGNTVVLKPASIAPGVVIEIARALDEAGLPDGVLNVVTGPGSSVGSEFIGNEGTDLVSFTGSSQVGEMVYEQATDAGKRVQTELGGKNPTLVADSANPAEAADIVANGGFGTTGQSCTACSRAIVHEDVYDDFVAELVDRAESLDVGPGTDHEMGPQVSESELSSTLEYIDIAEAEGATLVAGGGVPEGEAVETGHFVEPTVFTDVDPDMRIAQEEVFGPVVAVIEVSDFDEGLAVANDVDYGLSASIVTDDHTEANRFVDEVEAGVVKVNDKTTGLELHVPFGGFKRSSSETWREQGDAGLDFYTIEKTVYDSY