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HSD17B8

Gene
HSD17B8
Protein
Estradiol 17-beta-dehydrogenase 8
Organism
Homo sapiens
Length
261 amino acids
Function
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:17978863). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis (PubMed:19571038, PubMed:25203508). Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (PubMed:25203508).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.974 kDa
Sequence
MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM
Protein
Estradiol 17-beta-dehydrogenase 8: HSD17B8

Gene
HSD17B8
Protein
Estradiol 17-beta-dehydrogenase 8
Organism
Canis lupus familiaris
Length
259 amino acids
Function
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.712 kDa
Sequence
MASPLRLRSALALVTGAGSGIGRAVSVRLAKEGATVAACDLDRAAACETVWLLGGQGSEKVAPGGAHTAFQADVSEAGAVRRLLEQVQACFSRPPSVVVSCAGLTRDEFLLRMSEDDWDRVIAVNLKGIFLVTQAAAQALVSSGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFITTPMTQKVPQKVLDKVIGMIPMGHLGDPEDVADAVTFLASEDSGYITGASVEVTGGLYM
Protein
Estradiol 17-beta-dehydrogenase 8: HSD17B8

Gene
Hsd17b8
Protein
Estradiol 17-beta-dehydrogenase 8
Organism
Mus musculus
Length
259 amino acids
Function
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone (PubMed:9712896). The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.588 kDa
Sequence
MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDLDGAAAQDTVRLLGSPGSEDGAPRGKHAAFQADVSQGPAARRLLEEVQACFSRPPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIIGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKMPEKVKDKVTAMIPLGHMGDPEDVADVVAFLASEDSGYITGASVEVSGGLFM
Protein
Estradiol 17-beta-dehydrogenase 8: Hsd17b8

Gene
HSD17B8
Protein
Estradiol 17-beta-dehydrogenase 8
Organism
Sus scrofa
Length
259 amino acids
Function
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.622 kDa
Sequence
MASQLRLRSALALVTGAGSGIGRAVSVRLAAEGAAVAACDLDGAAAQETVQLLGGPGSEKGAPSGPMAAFQADVSEAETARRLLEQVQAYFFRPPSVVVSCAGITRDEFLLRMSEDDWDKVIAVNLKGIFLVTQAAAQALVSSGCPGSIINISSIIGKVGNMGQTNYAASKAGVIGLTQAVARELGRYRIRCNSVLPGFIKTPMAQKVPQKVLDKVVGMIPMGHLGGPPDVADVVAFLASEDSGYITGASVEVTGGLFM
Protein
Estradiol 17-beta-dehydrogenase 8: HSD17B8

Gene
Hsd17b8
Protein
Estradiol 17-beta-dehydrogenase 8
Organism
Rattus norvegicus
Length
259 amino acids
Function
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
26.791 kDa
Sequence
MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDLDGAAAQDTVRLLGNPGSEDREPRGKHAAFQADVSEGPAAKRLLEQVQACFFRPPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIVGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKMPEKVKDKVTAMIPLGHMGDPEDVADVVAFLASEDSGYITGASVEVSGGLFM
Protein
Estradiol 17-beta-dehydrogenase 8: Hsd17b8

Gene
HSD17B8
Protein
Estradiol 17-beta-dehydrogenase 8
Organism
Callithrix jacchus
Length
134 amino acids
Function
NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
13.763 kDa
Fragment
single
Sequence
DWDKVIAVNLKGTFLVTQAAGQALVSSGCSGSIINISSIVGKVGNMGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVMNKITGMIPMGHLGDPEDVADVVAFLASEDSGYITGAS
Protein
Estradiol 17-beta-dehydrogenase 8: HSD17B8