HSD17B1

Gene

Hsd17b1

Protein

Estradiol 17-beta-dehydrogenase 1

Organism

Mus musculus

Length

344 amino acids

Function

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Mass

36.785 kDa

Sequence

MDPTVVLITGCSSGIGMHLAVRLASDRSQSFKVYATLRDLKAQGPLLEAARTQGCPPGSLEILELDVRDSKSVAAAQACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFYEKLVGGPGGALERADAQTRHLFAHYLRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVAAMHQEAFSNLQTQENAKAGAQVPGVSDTASSALICLPECAIPRVASELGWSASDKPGQDNSCYQQKI

Protein

Estradiol 17-beta-dehydrogenase 1: Hsd17b1

Gene

Hsd17b1

Protein

Estradiol 17-beta-dehydrogenase 1

Organism

Rattus norvegicus

Length

344 amino acids

Function

Favors the reduction of estrogens and androgens. Uses preferentially NADH.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Mass

36.967 kDa

Sequence

MDSTVVLITGCSSGIGLHLAVRLASDRSQSFKVYATLRDLKSQGPLLEAARAQGCPPGSLEILELDVRDSESVAAARACVTEGRVDVLVCNAGRGLFGPLEAHELNAVGAVLDVNVLGTIRMLQAFLPDMKRRHSGRVLVTASVGGLMGLPFHEVYCASKFALEGLCESLAILLPLFGVHVSLIECGAVHTAFHEKLEGGPGGALERADAQTRHLFAHYQRGYEQALSEAQDPEEVTELFLTAMRAPQPALRYFSTNRFLPLARMRTEDPSGSSYVEAMHREAFSDLQVQEGAKAGAQVSGDPDTPPRALICLPECAIPRVTAELGWSASDKPGQNKSCYQQKI

Protein

Estradiol 17-beta-dehydrogenase 1: Hsd17b1

Gene

HSD17B1

Protein

Estradiol 17-beta-dehydrogenase 1

Organism

Homo sapiens

Length

328 amino acids

Function

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Mass

34.95 kDa

Sequence

MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ

Protein

Estradiol 17-beta-dehydrogenase 1: HSD17B1

Gene

HSD17B1

Protein

Estradiol 17-beta-dehydrogenase 1

Organism

Pan troglodytes

Length

328 amino acids

Function

Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Mass

34.889 kDa

Sequence

MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRVLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGPSAVGDPELGDPPAAPQ

Protein

Estradiol 17-beta-dehydrogenase 1: HSD17B1