Protein
L-Lys-D/L-Arg epimerase
Organism
Desulfobacterium autotrophicum (strain ATCC 43914 / DSM 3382 / HRM2)
Function
Catalyzes the epimerization of L-Lys-L-Arg to L-Lys-D-Arg (in vitro). Catalyzes the epimerization of positively charged dipeptides, with a preference for substrates with a basic amino acid in the second position. Has epimerase activity with L-Lys-L-Lys, L-Arg-L-Arg, L-Val-L-Arg, L-Val-L-Lys and L-Ala-L-Arg (in vitro).
Similarity
Belongs to the mandelate racemase/muconate lactonizing enzyme family.
Sequence
MKIKEITIWKEDLALTRPYTIAYETISAVENVFVLLETDNGITGIGAGSPAEDVTGETITATETALSLKLAPILQGKDIRSCFSLLKELNTALADTPAALAAADIALHDLAAKTMGLPLVDLLGRVHDRLPTSITIGIMPVKETLAEAEEYLGRGFSILKIKTGLNVEEDIERIIRLNETFKSKICMRVDANQGYEVEELHHFFKKTVGLVEFIEQPLKAEHLEKMGQLPQAIRRVSAADETLLGPRDAAQMLHAPRPFGIFNIKLMKCGGIAPGLEIANMAGHADIDLMWGCMDESIVSIAGALHAAFSSRATRYLDLDGSLDLARDIVNGGFILENGWMRTTDQPGLGVKRI