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HPGD

Gene
Hpgd
Protein
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Organism
Mus musculus
Length
269 amino acids
Function
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
29.181 kDa
Sequence
MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQIKAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS

Gene
HPGD
Protein
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Organism
Bos taurus
Length
266 amino acids
Function
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
29.026 kDa
Sequence
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFIQCDVADQEQLRDTFRKVVDHFGKLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGININMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAMAANLMNSGVRLNAICPGFVDTPILKSIEKEENMGKYIEYMGPIKDMMKYYGILDPSMIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFHMKMQ

Gene
HPGD
Protein
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Organism
Homo sapiens
Length
266 amino acids
Function
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
28.977 kDa
Sequence
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ

Gene
HPGD
Protein
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Organism
Macaca fascicularis
Length
266 amino acids
Function
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
28.933 kDa
Sequence
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEKFEPQKTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYDATPFQAKSQ

Gene
Hpgd
Protein
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Organism
Rattus norvegicus
Length
266 amino acids
Function
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
28.939 kDa
Sequence
MHVNGKVALVTGAAQGIGKAFTEALLLHGAKVALVDWNLETGVKCKAALDEQFEPQKTLFIQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINISSIAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVKTPILESIEKEENMGQYIEYTDQIKAMMKFYGILDPSAIANGLINLIEDDALNGAIMKITASKGIHFQDYDLFPSFSKAP

Gene
HPGD
Protein
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Organism
Cavia porcellus
Length
265 amino acids
Function
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity).
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
28.886 kDa
Sequence
MHVNGKVALVTGAAQGIGRAFAEGLLHKGAKVALVDWNLEAGVKCKAALDEEFEPQKTLFIQCDVADQEQLRDTFTKVVDYFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQHGGEGGVIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMARKLMNSGVRMNAICPGFVNTSILQSIEKEENMGPYIEYTGHIKDMMKCYGILDPEMIANGLITLIEDDDLNGAIMKITTSNGIHFQDYDTAPSYAKD