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HOXA1

Gene
HOXA1
Protein
Homeobox protein Hox-A1
Organism
Homo sapiens
Length
335 amino acids
Function
Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (PubMed:16155570). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).
Similarity
Belongs to the Antp homeobox family. Labial subfamily.
Mass
36.641 kDa
Sequence
MDNARMNSFLEYPILSSGDSGTCSARAYPSDHRITTFQSCAVSANSCGGDDRFLVGRGVQIGSPHHHHHHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGSQNFSAPYSPYALNQEADVSGGYPQCAPAVYSGNLSSPMVQHHHHHQGYAGGAVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGNDEKAEESSEKSSSSPCVPSPGSSTSDTLTTSH

Gene
Hoxa1
Protein
Homeobox protein Hox-A1
Organism
Rattus norvegicus
Length
333 amino acids
Function
Sequence-specific transcription factor (By similarity). Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior (By similarity). Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments (By similarity). Activates transcription in the presence of PBX1A and PKNOX1 (By similarity).
Similarity
Belongs to the Antp homeobox family. Labial subfamily.
Mass
36.124 kDa
Sequence
MDNARLNSFLEYPILGSGDSGTCSARVYSSDHGITTFQSCAVSANSCGGDDRFLGGRGVQITSPHHHHHHHHHPQPATYQTSGNLGVSYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYPPCAPAVYSGNLSSPMVQHHHHHQGYAGGTVGSPQYIHHSYGQEHQSLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARSEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPMSPATPPGSDEKTEESSEKSSSSPSAPSPASSTSDTLTTSH

Gene
Hoxa1
Protein
Homeobox protein Hox-A1
Organism
Mus musculus
Length
331 amino acids
Function
The homeoboxless ERA-1-399 protein could act as a competitive inhibitor of the ERA-1-993 protein by competing for interaction with regulatory protein(s) while being unable to bind to DNA.
Similarity
Belongs to the Antp homeobox family. Labial subfamily.
Mass
36.037 kDa
Sequence
MNSFLEYPILGSGDSGTCSARAYPSDHGITTFQSCAVSANSCGGDDRFLVGRGVQISSPHHHHHHHHHHHPQTATYQTSGNLGISYSHSSCGPSYGAQNFSAPYGPYGLNQEADVSGGYPPCAPAVYSGNLSTPMVQHHHHHQGYAGGTVGSPQYIHHSYGQEQQTLALATYNNSLSPLHASHQEACRSPASETSSPAQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGLLPISPATPPGSDEKTEESSEKSSPSPSAPSPASSTSDTLTTSH

Gene
HOXA1
Protein
Homeobox protein Hox-A1
Organism
Heterodontus francisci
Length
326 amino acids
Function
Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.
Similarity
Belongs to the Antp homeobox family. Labial subfamily.
Mass
35.419 kDa
Sequence
MDNARMNSFLDYSIINGETGTCSSRSYHADQGITTYQSCAVSNNNCNADDRYIVSRSVQIGAPPPHHHHHQSNYTHPNNLGISYSAHPNCGAGYPAQSFNTGYSHHYSLNQETDGNGGYPQCAPAVYPGNIASAISPHHHSYGGMVGSGQYPHHPYGQEQQGLALAAGCHSLSPVHGSHQEACCSPSAETPPPAQTFDWMKVKRNPPKTGKAGEYGFAGQPNTVRTNFTTKQLTELEKEFHFNKYLTRARRVEIAAALQLNETQVKIWFQNRRMKQKKREKEGLTSASPATPGSEANTEDTSDKCNSTSSTPSPSSSTSETINTSG

Gene
hoxa1
Protein
Homeobox protein Hox-A1
Organism
Xenopus laevis
Length
240 amino acids
Function
Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.
Similarity
Belongs to the Antp homeobox family. Labial subfamily.
Mass
26.585 kDa
Fragment
single
Sequence
AYAHSSCGSNYGMQNFSPGYSHFPIHQETEVSSGFPQSVYSGNIASSVVQHQQHQSYIEGSAHYIHHSYGPEQNLSVANYNNNVASLHISQREVCHSPSSETSPGPTQTFDWMKVKRNPPKTGKAGEYGYAGQPNTARTNFTTKQLTELEKEFHFNKYLTRARRVEIAAALQLNETQVKIWFQNRRMKQKKREKEGLLPISPSTSTGSDEKSEELSEKSNSSPCAPSPASSTSDHLSASG