Protein
Biotin biosynthesis bifunctional protein BioWF
Organism
Propionibacterium acnes (strain SK137)
Function
Catalyzes both the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide, and the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
Similarity
In the C-terminal section; belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.
Sequence
MVFNCYPVANAEESPMSSQNPTTVAWWSVRMRATGTLDDEPYHVSGAESLVAPGMIEQTVAGLTQRALAPGHTVKARQVRVSLDQLDVEPTIIPALPTELKECPDPVAARQYFVDVLSRFVPHPAEALRVLTEGPTMRGAAMVEAGTDRRLEADPLRGVRVTKFGDLTESAPGASLAHKKHHHEAVLLASKVAAAPGVLAEFCISDDPHYTRGYVCVDGVYTTVTNVKADGDPNGGRVILVDTARADPTTITTWLENHPVLIGPATASSQKATSWHGHLCGRLNAWRAAGLERRPRTFCSAQDPDAVTTDGPALLFSSSDYLGLSTEPKVQQAMNNTVRRLGSSSGGSRLTTGTSVAHHQAEHEIAAWLGYPQAVFMASGYQANIATIQLLADPHVTVISDAENHASLIDGCRLARARTVVVPHADLDVIDTALDCVTTDRALVLTEGVYSMGGDVAPVGELVEIAHRHGALVVVDDAHGIGTVGPTGRGATEELPASQRPDVLLGTASKALGVEGGFACLDETLATLMRNCARGYVFSSAPSPVVAAGVAAAVEYLRTDTRRVCSLQANVAQARLLLAEADLIPPSAAHDRGPIIRIPVGPESRAVAAQEELARRGLMVGAIRYPAVARGDAILRICLTARHTDEHIRILVTSLREVLDGALSDAPR