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HHT4

Gene
HHT4
Protein
Histone H3.4
Organism
Tetrahymena thermophila (strain SB210)
Length
136 amino acids
Function
Macronuclear replacement variant which replaces conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Functions redundantly to H3.3. H3.4 deposition is mainly transcription-associated, DNA replication-independent. Although not essential for vegetative growth, minor H3 variants are required for producing viable conjugation progeny by affecting late developmental stages of conjugation.
Similarity
Belongs to the histone H3 family.
Mass
15.525 kDa
Sequence
MARTKQTARKSTSIKAPRKQLAAKAARKSAPISGGIKKPHKFRPGTVALREIRKYQKTTDLLIRKLPFQRLVRDIAMEMKSDIRFQSQAILALQEAAEAYLVGLFEDTNLCAIHARRVTIMTKDLHLARRIRGERF