HEM3

Gene

HEM3

Protein

Porphobilinogen deaminase

Organism

Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)

Length

361 amino acids

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Similarity

Belongs to the HMBS family.

Mass

39.687 kDa

Sequence

MPHNTKSMDNTLNIKDNHVQIGGRKSKLAVVQSEIVKECIVEKFPELSCSVLALSTLGDKVQSKPLYSFGGKALWTKELEILLLEQVEEYPRLDLIVHSLKDIPTNLPEEFELGCILNREDARDALVMKSGSSYKSLADLPDGSLVGTSSVRRSSQLLKNHPKLRFDSVRGNLQTRLNKLDDENSPFECLLLASAGLIRIGLGDRITAHLDAPEMYYAVGQGALGIEIRKGDEKMLQLLKTIEDLPTTYCCLAERSLMRHLEGGCSVPIGVQSHYNESTNELSLKAIIVSPDGIHFVEDEYKGVVNNKDDADAIGIKVGDLLSAKGGREILNSINFERINLPPSSNTPTPQPITPITTNNS

Protein

Porphobilinogen deaminase: HEM3

Gene

HEM3

Protein

Porphobilinogen deaminase

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876)

Length

340 amino acids

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Similarity

Belongs to the HMBS family.

Mass

37.756 kDa

Sequence

MPHHIMSINDSNHVQIGGRKSKLAVVQSEIVKKVIEDTFPNLSCSILALSTLGDKVQTQPLYTFGGKSLWTKELEILLLDSVDEFPKLDLIVHSLKDMPTNLPEEFELGCIFQREDPRDAIVMKQGSSYKSLKDLPAGAIVGTSSIRRSSQLIKNYPHLRFESVRGNIQTRLNKLDQPNNEYCCLILASAGLIRLGLGHRITSYLDDMYYAVGQGALGIEIRKGDDNIKSILKKIEDPIATICCLAERSLMRYLEGGCSVPLGVHSDYNESKQELTLKGIIVSPDGTVSIEDEVIKRITCDEDCEQVGIELGDKLKAKGAKEILDKIDMTRNINARPTEV

Protein

Porphobilinogen deaminase: HEM3

Gene

HEM3

Protein

Porphobilinogen deaminase

Organism

Yarrowia lipolytica (strain CLIB 122 / E 150)

Length

338 amino acids

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Similarity

Belongs to the HMBS family.

Mass

36.947 kDa

Sequence

MSVEERPVIFDDQSELPKVFVGGRKSKLALVQTQHVAAMLKKVHPDYSFPVLGLTTLGDQVQSKPLYSFDGKALWTKELETLLLEKVPGFDQQDIIVHSLKDMPTVLPDGCELGAILTREDPRDALVMAAGSPYKTLADLPAGSVVGTSSIRRSAQLKKSYPGLVYESVRGNVGTRLSKLDDPETPYKCLILAAAGLKRLDLGDRITGYLQKPDMLHAVGQGALGLEIRQGDEKTKKILEAIYDKESTLCCLAERAVMRTLEGGCSVPIGVETKYENGKLTLDAIVVSVEGTEFVECTQVRAVEENWEAEQLGKDVAEQLVKDGAKKILDAIHLENIK

Protein

Porphobilinogen deaminase: HEM3

Gene

hem3

Protein

Porphobilinogen deaminase

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

336 amino acids

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Similarity

Belongs to the HMBS family.

Mass

36.827 kDa

Sequence

MPSCTSFPIGTRKSKLAVIQSEIIREELEKHYPHLEFPIISRDTIGDEILSKALFEFKRQLAKSLWTRELEALLVTNQCRILVHSLKDLPSEMPDGMVIACIPKRSCPLDAIVFKAGSHYKTVADLPPGSVVGTSSIRRRALLARNFPHLRFVDIRGNVGTRLAKLDAPDSQFDCLVLAAAGLFRLGLKDRIAQMLTAPFVYYAVGQGALAVEVRADDKEMIEMLKPLQHQETLYACLAERALMKRLQGGCAIPIGVQTDVLAISNSSYRISLLGTVLSADGLRAAFGNAEAVVSSEEEAEELGITVALALLKNGAGPILEEHQRSSDSEESLKNY

Protein

Porphobilinogen deaminase: hem3

Gene

HEM3

Protein

Porphobilinogen deaminase

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)

Length

329 amino acids

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Similarity

Belongs to the HMBS family.

Mass

36.835 kDa

Sequence

MTRESINIGGRRSKLAVVQSNHVRDLVQAKFPQYDCTVFTLQTLGDQIQFKPLYSFGGKALWTKELEDYLYCEDQEKRLDLIVHSLKDMPTLLPDGFELGCVTKRVDPTDCIVMPRGSPHRCLADLPEGAVVGTSSVRRSAQLKRKFPHLKYQSVRGNIHTRLEKLDDPEGPFQCLVLASAGLVRMGLEDRITQRLHSDIMYHAVGQGALGIEIRQGDKKILQILDEIADLESTVCCLAERSLMRTLEGGCSVPIGVESSYDHKTKKLLLKGIVVNVEGTMAIEDQQEVVVNDIREDSIKCGVLLAHKMIKDGAKKILDEINLERVIQQ

Protein

Porphobilinogen deaminase: HEM3

Gene

HEM3

Protein

Porphobilinogen deaminase

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

327 amino acids

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Similarity

Belongs to the HMBS family.

Mass

36.675 kDa

Sequence

MGPETLHIGGRKSKLAVIQSNHVLKLIEEKYPDYDCKVFTLQTLGDQIQFKPLYSFGGKALWTKELEDHLYHDDPSKKLDLIVHSLKDMPTLLPEGFELGGITKRVDPTDCLVMPFYSAYKSLDDLPDGGIVGTSSVRRSAQLKRKYPHLKFESVRGNIQTRLQKLDDPKSPYQCIILASAGLMRMGLENRITQRFHSDTMYHAVGQGALGIEIRKGDTKMMKILDEICDLNATICCLSERALMRTLEGGCSVPIGVESKYNEETKKLLLKAIVVDVEGTEAVEDEIEMLIENVKEDSMACGKILAERMIADGAKKILDEINLDRIK

Protein

Porphobilinogen deaminase: HEM3

Gene

HEM3

Protein

Porphobilinogen deaminase

Organism

Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)

Length

326 amino acids

Function

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.

Similarity

Belongs to the HMBS family.

Mass

35.526 kDa

Sequence

MGEETLRIAGRRSKLAVIQSESVKEIVQREFPNYTCTVLAKQTLGDQVQSKPLYAFGGKALWTKELEDLLYEEDLDQRIDMIVHSLKDMPTQLPEGFELGAITKRVDPSDCLVMAAGSPYKTLGDLPNGSVVGTSSIRRSAQLRRRYPHLVFASVRGNIQTRLKKLDDPENECKCIILATAGLVRLGLESRITQRFDSTIMLHAVGQGALGIETRTGDERLQAILAKVADRNSTICCLAERSLMRTLEGGCSVPIGVYSTFDEETSMLTLDGLVVSVDGADAAEATVSYKIKSDKEDAIACGQLLAAKLLEAGAKKILDAIHLPEA

Protein

Porphobilinogen deaminase: HEM3