Protein
Lipoyl synthase, mitochondrial
Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Sequence
MATSAGKLRTLYSAHSSLSSLPPSARPTLQLATLRSYATTTPHDSPIGNTSNTPPTVKRPATAFKDKLNAGPAFSDFVSGKKDEPLDPAEAYALKTALVGPPGRKKEITRLPPWLKTAIPDSSNYKRIKNDLRGLNLHTVCEEARCPNIADCWGGSSKSAATATIMLMGDTCTRGCRFCSVKTSNKPPPLDPHEPDNTAEALSRWGLGYVVLTSVDRDDLADGGARHFAETVMKIKQKAPNILVECLTGDYAGDLDMVALVANSGLDVFAHNVETVEALTPFVRDRRASFQQSLRVLKAAKAAKPELITKTSLMLGLGETEAQLWDALRALRAINVDVVTFGQYMRPTKRHMAVHEYVRPDVFDLWKERALEMGFLYCASGPLVRSSYKAGEAFIENVLKKRRGENAGSVNEKVTTSENVKKLVAGEAMM