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HBZ

Gene
HBZ
Protein
HTLV-1 basic zipper factor
Organism
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A)
Length
209 amino acids
Function
Contributes to the regulation of viral RNA transcription by interacting with host proteins involved in transcriptional activation such as ATF4, or CREB1, and by inhibiting their activity. Additionally, HBZ suppresses host NF-kappa-B-driven transcription mediated by host RELA as well as transcription of some classical NF-kappa-B target genes, including IL8, IL2RA, IRF4, VCAM1, and VEGFA.
Similarity
Belongs to the HTLV-1 HBZ protein family.
Mass
24.893 kDa
Sequence
MVNFVSAGLFRCLPVSCPEDLLVEELVDGLLSLEEELKDKEEEEAVLDGLLSLEEESRGRLRRGPPGEKAPPRGETHRDRQRRAEEKRKRKKEREKEEEKQTAEYLKRKEEEKARRRRRAEKKAADVARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELGIDGYTRQLEGEVESLEAERRKLLQEKEDLMGEVNYWQGRLEAMWLQ

Gene
HBZ
Protein
HTLV-1 basic zipper factor
Organism
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A)
Length
209 amino acids
Function
Enhances viral infectivity and persistence, and facilitates proliferation of HTLV-1-infected lymphocytes (PubMed:16424388). Mechanistically, inhibits Tax-mediated viral replication and NF-kappa-B activation (PubMed:18599479, PubMed:21552325). Plays a role in allowing infected T-cells to escape the cytotoxic T-lymphocyte response by maintaining low levels of viral protein production. Inhibits also host EP300 histone acetyltransferase (HAT) activity, reducing levels of acetylated histone H3 at 'Lys-18' (H3K18ac) in infected cells (PubMed:22434882). Contributes to the accumulation of chromosomal abnormalities by inhibiting double-stranded DNA breaks (DSB) repair through the NHEJ pathway (PubMed:29769340). Participates in the modulation of host immune response at multiple levels contributing to abnormal interferon signaling and viral pathogenesis (PubMed:28768861).
Similarity
Belongs to the HTLV-1 HBZ protein family.
Mass
24.936 kDa
Sequence
MVNFVSVGLFRCLPVPCPEDLLVEELVDGLLSLEEELKDKEEEETVLDGLLSLEEESRGRLRRGPPGGKAPPRGETHRDRQRRAEEKRKRKKEREKEEEKQIAEYLKRKEEEKARRRKRAEEKAADFARRKQEEQERRERKWRQGAEKAKQHSARKEKMQELGVDGYTRQLEGEVESLEAERRRLLQEKEDLMGEVNYWQGRLEAMWLQ

Gene
HBZ
Protein
HTLV-1 basic zipper factor
Organism
Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C)
Length
208 amino acids
Function
Contributes to the regulation of viral RNA transcription by interacting with host proteins involved in transcriptional activation such as ATF4, or CREB1, and by inhibiting their activity. Additionally, HBZ suppresses host NF-kappa-B-driven transcription mediated by host RELA as well as transcription of some classical NF-kappa-B target genes, including IL8, IL2RA, IRF4, VCAM1, and VEGFA (By similarity).
Similarity
Belongs to the HTLV-1 HBZ protein family.
Mass
25.018 kDa
Sequence
MINFVFVGPFRCLPVPCPEDLLVEDLVDGLLSLEDELKDQREEEESVLDGVLSLEEESRLRWGPVGEEAPPRGETHRDRQRRAEEKRKRKREREKEEEKQIAEFLKRKREKEAWRRRRAEEKAADRARRKLEEEERRERKWRQTEQGAKQRSARKEKMTELGVDGYARQLESEAESLEAERGRLLQENDDLMGEVNYWQRRLEAMWSQ

Gene
HBZ
Protein
Hemoglobin subunit zeta
Organism
Homo sapiens
Length
142 amino acids
Function
The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.
Similarity
Belongs to the globin family.
Mass
15.637 kDa
Sequence
MSLTKTERTIIVSMWAKISTQADTIGTETLERLFLSHPQTKTYFPHFDLHPGSAQLRAHGSKVVAAVGDAVKSIDDIGGALSKLSELHAYILRVDPVNFKLLSHCLLVTLAARFPADFTAEAHAAWDKFLSVVSSVLTEKYR

Gene
Hbz
Protein
Hemoglobin subunit zeta
Organism
Mus musculus
Length
142 amino acids
Function
The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.
Similarity
Belongs to the globin family.
Mass
16.235 kDa
Sequence
MSLMKNERAIIMSMWEKMAAQAEPIGTETLERLFCSYPQTKTYFPHFDLHHGSQQLRAHGFKIMTAVGDAVKSIDNLSSALTKLSELHAYILRVDPVNFKLLSHCLLVTMAARFPADFTPEVHEAWDKFMSILSSILTEKYR