Protein
Adenylate kinase isoenzyme 6 homolog HBR1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Function
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation (By similarity). Induces transcription of mating-type proteins ALPHA1 and ALPHA2 and moderately represses transcription of mating-type protein A1 in response to hemoglobin and growth signals. Involved in the induction of a high affinity fibronectin receptor by sub-inhibitory dosages of caspofungin.
Similarity
Belongs to the adenylate kinase family. AK6 subfamily.
Sequence
MTTMSRRYTPNIIITGTPGCGKSSHSSSLVSQLNQTLGKETTIHFKHFNISEIAKERDCIESYDAKLDTSIVDEDKLLDSLEPDLEKGGVVVDWHCCDIFPERLIDLVVVLRTDNSNLFDRLKTRNYNDLKLQENLDCEIMEVILQEAKDSYIPDIVIELRSDTAEEMDENVDRISSWVETWIEDHPDGVSNELNKQYNPDDSSDEGDDNSDSDEYELEEDEQEEEEEREEYDEETNEEMEHTEDIAQ